The protagonist, and as far as he knows, the only survivor of the plague. Once a factory worker, Neville now spends his days hunting vampires or repairing his house, while hiding in his home at night. Due to months and then years of isolation, Neville grows increasingly depressed and unstable.
Action Dad: He was a father, but his daughter, Kathy, died from the plague. He had to have her body burned in order to prevent reanimation.
Action Survivor: Neville is tough, but his still an average person. The reason he can so easily kill or capture vampires is because they're in a coma, or sleeping very heavily, during the day. He is captured relatively easily by members of the new society.
The Alcoholic: At first, in order to cope with his isolation. He eventually stops for reasons he cannot reasonably explain.
Badass: Nevile can hold his own while fighting vampires.
Badass Beard: Ends up growing one, due to the lack of need to shave.
Badass Bookworm: Starting from Part II, he spends a lot of his time studying the bacteria, trying to find a cure, or experimenting on vampires (living or dead). He is not an expert in any of this, however.
Driven to Suicide: Neville takes many risky actions throughout the story, such as fighting a horde of vampires or drinking heavily. He always stops before it is too late, however. He kills himself using pills given to him by Ruth, because he fears a violent, painful execution.
Good Is Not Nice: Neville lost most of his social skills due spending years by himself, but he is still a good person at heart and is willing to accept being punished by the new society for his crimes.
Sanity Slippage: Throughout the story, though he seems to grow more stable at the end.
Vampire Hunter: When not working on his house, Neville spends his day looking for supplies and killing sleeping vampires.
"Come out, Neville!"
Neville's former neighbor and a vampire. Every night, he comes to Neville's house, and shouts at and harasses Neville, telling him to come out of his house. By vampire standards, he is remarkably intelligent, capable of speaking a few words and limited tactical planning.
Climbing Climax: He tries to escape from the new society's soldiers by climbing up and hiding in a chimney. He fails, eventually being knocked off the roof due to machine gun fire. He is then stabbed with a lance, which presumably kills him.
Evil Former Friend: Cortman was a neighbor and friend to Neville. After Cortman returned from the dead, he began hunting Neville.
Genre Savvy: He laughs at Neville whenever he tries to use traditional vampires wards like running water, or a cross (being Jewish, has no reason to fear the cross). He is also the only vampire who seems to be clever enough to try to escape from Ruth's people, but he is unsuccessful.
Say My Name: When he can see Neville, he will just shout "Neville!" It appears to be one of the only three words he can say.
Too Dumb to Live: He tries to hide in his chimney when soldiers begin killing vampires outside Neville's house, even after they see him climbing up the house, have a spotlight on him, and a firing upon him. Despite all his cleverness, he is still just one of the dead vampires.
Laughably Evil: Ben is often whimsical in his behavior, often teasing or laughing at Neville.
Worthy Opponent: Neville seems to think of him this way, at least. Neville remarks he doesn't deserve to be butchered by the new society's vampire hunters.
A dog that Neville notices around his house. Due to years of isolation, Neville tries to befriend it, but it is terrified of him.
Canine Companion: Subverted. Neville tries to take the dog as a per, but it is too scared of him and refuses to let him touch it. It eventually starts to trust Neville a bit more, but ends up getting infected before completely warming up to him.
Zombie Infectee: It disappears for a few days, and when it returns, it is implied to have been bitten. Neville tries to save it, but it dies after a week.
The only uninfected survivor Neville comes across. She claims to have lived with her husband until he was killed by vampires a few weeks ago. Initially distrustful of Neville, she eventually grows closer to him.
Bad Liar: Ruth isn't a particularly convincing liar, and she appears to make up her story as she goes. Neville continuously tells himself that he is just being paranoid whenever he finds a hole in her story.
Becoming the Mask: Ruth ends up caring for Neville, even though he killed her husband, after learning that he is not really a monster or even a particularly cruel person. She leaves him a note, begging him to escape before he is captured, and gives him pills that would kill him in order to spare him a violent execution.
Daywalking Vampire: Ruth is infected just like everyone else, but it capable of walking in the sun for short periods of time due to medication.
Did Not Die That Way: Not Ruth herself, but her husband. She claims he was killed by vampires, but he was actually killed by Neville.
Friendly Neighborhood Vampire: Ruth is shown to be a kind person, despite being infected. Justified in that most living infected are otherwise normal people, particularly after they begin taking medication.
Obfuscating Stupidity: She asks Neville a lot of questions about the vampires that he thinks would be obvious, and that she would have to know to survive. It turns out she was most likely just testing his knowledge on the bacteria.