- The very first episode "Ghosts R Us", has the team chasing down both the ghosts who have been driving them out of business and a gigantic toy monster rampaging after them. The coup de grâce is when Egon essentially makes a bomb out of his pack that completely annihilates the monstrosity after it re-emerges from falling into the bay above the bridge they are on.
- The final battle in "The Collect Call of Cathulhu." Egon's explanation on how they are going to defeat "Cathulhu" is not only scientifically sound — it can be done in reality.
- The train fight and closing the gate in "Knock Knock"
- In "Mr. Sandman, Dream Me a Dream," after the more scientifically-minded Ghostbusters are incapacitated, everyman Winston realizes how to and successfully defeats the Sandman.
- And his plan gives Janine a CMOA into the bargain: after the Sandman puts her to sleep and turns his attention to Winston, we see the sleeping Janine muttering, "I'm a... I'm a... I'M A GHOSTBUSTER!" Dream Janine appears in full uniform, grabs the spare thrower Winston left on the desk, complete with Theme Music Power-Up, and kicks the Sandman's ass along with Winston.
- The entire plan in "The Headless Motorcyclist," culminating in using a complex holographic array to fool the Headless Horseman — now on a motorcycle — into crossing the bridge, stopping him cold, and allowing him to be trapped was pretty freakin' sweet, too. Low key can still be awesome.
- The climax to "Venkman's Ghost Repellers", where the boys make a spectacular entrance to save Peter's dad from a horde of ghosts, with a kick-ass original song playing.
- In "Revenge of the Ghostmaster," the titular spook casts a spell on the Ghostbusters and Slimer that prevents any technology from working within forty feet of them. Egon and Ray, however, figure out a Rube Goldberg-like way to trap him.
- The climactic scene of "The Spirit of Aunt Lois". After spending much of the episode being harassed and humiliated by the Domovoi spirits Dr. Basingame riled up, the Ghostbusters finally get to strap on their proton packs (which they couldn't use before as Aunt Lois was in the line of fire), march straight in, deliver a Pre Ass Kicking One Liner or two and cut loose on the spooks. It's helped a lot by some excellent animation and a Crowning Moment of Funny for Peter when he says "Smile!" to a haunted statue before blasting it straight into a waiting ghost trap.
- In "Ghost Busted," due to a lack of haunting, the guys decide to alter their devices to capture criminals instead. They essentially eradicate crime in New York City; if the ghosts hadn't started reappearing, who knows what they would have gone after next.
- How do you stop the ghost of an old-time jazzman from reverting time to the 1920's with his magic music? An equal and opposing force, primal and emotional. In other words: The Power of Rock.
- In "Beneath These Streets", Ray believes the earthquakes rocking New York are caused by a giant pillar that holds Manhattan up. After the guys dismiss his theory as some old urban legend, he goes by himself down into the sewers and discovers he was right and ghosts are causing the quakes by blocking the lubricant. He fights the ghosts until his proton pack runs out of juice, then prepares to fight hand-to-hand when the rest of the guys show up.
- The Big Damn Heroes moment in "They Call Me MISTER Slimer!", when the guys blast a group Barrow-wights that had trapped some kids (with an assist by Slimer, who carves a baseball bat out of his body and goes to town on them as well.)
Winston: Let 'em have it!
- In "The Boogie Man Cometh", the ghost of a dead gangster tries to intimidate the gang with one hell of a nightmare face. Our boys don't even flinch, with Peter summing it up, "Take away those supernatural powers, and you're just another two bit dead hood."
- Peter defeats the first Fire Fly in "Troll Bridge" by turning a water main on it. Egon, seeing the result, quickly discerns that the Fire Flies are vulnerable to water, and brings a water tower down on the others.
- Rigging up a device to defeat Necksa and save his three friends all on his own in "The Devil in the Deep."
- In "Devil To Pay," Peter gets Winston and Ray onto a gameshow to score a free vacation to Tahiti. The gameshow turns out to be a front for a minor demon (Dib) to steal people's souls. After a series of challenges and a near-death experience, the guys make it out alive with their souls, but without the free vacation. Peter assaults Dib, screams at him, demands the vacation and gets his way - without using a proton pack.
- To add a CMOF, we later see Dib sent them on their free vacation — and they're on a castle-like structure overlooking Tahiti. What was it made of? Another part of "First Prize" — three tons of deviled ham.
- Peter gets to show off his Guile Hero skills in "You Can't Take It With You." An old millionaire has opened a portal to send all his money to the Spirit World before he dies, never mind that hordes of ghosts are streaming through the opening. The Ghostbusters can't get past his security system to shut it off, but Egon realizes it would shut off and close the portal if they could get it to overload, but how? Peter steps out and taunts the guy about how he may be able to take his fortune with him, but he'll have to leave behind his mansion, which is worth much more, so they'll make sure it's donated to charity. It works — the guy turns up the machine to teleport the entire building, which not only overloads and destroys his equipment but displaces all the money he'd already sent over, sending it back to Earth.
- In "Rollerghoster" a carnival ride is possessed by the spirits of circus animals who died in a fire decades earlier. Peter calls up a friend of his in the special effects business for all the mylar he's got. He then has the mylar rolled down the side of a building to create a giant funhouse mirror, and builds a bonfire in front of it. When Egon asks what he's doing, Peter says that he believes if the ghosts see another giant fire it will drive them out into the open and they can trap them. It works perfectly.
- In "Lights! Camera! Haunting!", the guys have been captured by ghosts working with a filmmaker and are about to be blasted with their own proton packs. Just before the ghosts can fire, Ray reverses the polarity of his PKE Meter so that it sends signals to ghosts rather than receives them. Then out of nowhere, a cowboy, pirate and soldier in a jeep appear:
Egon: It's the ghosts of the studio's old movie stars.Peter: Swift move, Ray. Only how do you know they won't side with the ghosts?Ray: Because... they're heroes!
- Show any kid with a fear of the Bogeyman the episodes "The Boogieman Cometh" and "The Bogeyman is Back". Watching Egon overcome his (relatable) childhood fears and bust the Bogeyman had to have struck a chord with many kids. It sure did with this troper. In "The Bogeyman is Back", for one, the titular demon has the Ghostbusters, including his childhood victim Egon, at his mercy when the Junior Ghostbusters turn up. The Bogeyman turns around and starts threatening them instead. Egon's fury at this overcomes his fear and allows him to break free of the Bogeyman's control, grab a proton pack and proceed to turn the tables on his arch-nemesis in a matter of seconds. Moral of the story: do not threaten children in front of Egon Spengler.
- Egon giving a ghost a "The Reason You Suck" Speech in "Ghostworld", infuriating him and keeping him busy while Janine and his mother free the rest of the guys from the ghost's control. At the very end, the 'busters put him down.
Egon: Checkmate!Ghost: But you are my servants!Peter: Sorry, big fella. It's servant's night off.
- In "Partners in Slime," Poso (a gangster-like ghost) has Janine and Louis kidnapped to force the Ghostbusters into giving up their technology, which he can use to be in charge of all other ghosts. Three of his goons go to the Firehouse to demand a surrender — finding Egon unarmed and alone. They specifically demand to see how the Containment Unit works.
Egon: And this lever opens the trap.
(the three ghosts get sucked into the Containment Unit)
Egon: And that concludes our tour.
- In "The Thing in Mrs. Faversham's Attic", he taunts the titular specter into getting close enough to be contained in a trap.
Ghost: Your time has ended!Egon: Not my time. Yours. Smile for the birdie! (opens trap)
- The baseball episode where Winston helps a team of good spirits against the evil ones. When he hit that last pitch (hurled by a giant one-eyed anthropomorphic elephant, no less!) and sent that sucker flying into the scoreboard, shattering it into as million pieces? Woohoo!
- Showing up to save the Carter kids from the Boogieman and standing guard over them all night while the other three search for the portal they need.
- Being the only one not to get sucked into the "Ghostbuster of the Year" competition and reminding his friends they're a team, not rivals. They all eventually regret not listening to him.
- Janine rescuing the guys from a near-Gozer-level entity in "Janine Melnitz, Ghostbuster" tends to stick out for Janine fans.
Receptionist: No one sees Proteus without an appointment.Janine: I got your appointment right here. BLAST
- An evil spirit has been slowly but surely removing Janine's humanity while making her "prettier" and "more desirable." She was literally minutes away from a full transformation when the guys show up and evoke the Power of Love. She then uses the supernatual powers of the being she had almost become to kick the spirit's ass.
- Destroying the Monster of the Week's power source in "20,000 Leagues Under The Street."
- In "Drool, The Dog-faced Goblin," Drool, a small phase-shifter, makes a Heroic Sacrifice to stop a much larger and meaner phase-shifter. Up to this point, Peter absolutely hated Drool and wanted to blast the poor thing. At the end, he was forced to admit he was wrong.
Peter: I take it all back, buddy.
- In "Revenge of Murray the Mantis," the boys release Mr. Stay-Puft himself in order to bring down a gigantic praying mantis. The fistfight between the titans is epic.
- The climax of "Ragnarok and Roll" was very affecting to this troper. Seeing D'tillio, the villain's somewhat snarky yet still staunchly loyal hunchback finally snap and tell him where to stick his wretched nihilism while he's hanging off the side of a building by his fingers was wonderful.
D'tillio: Look at me! I'm small and weak and ugly, but at least I'm still human! If you weren't sufficiently loved, it's your own fault, and not the world's! You had everything, I had nothing, but I'll have more love and decency in my going out then you ever will!
- In "Ghostworld," everyone at the firehouse is possessed when they visit the titular amusement park—everyone except Egon, who catches a bad cold and doesn't go. Instead, his well-meaning but overbearing mother comes to take care of him. When Egon realizes something is up and travels to the park, Mrs. Spengler goes right along with him...and proves invaluable:
- When Egon and Mrs. Spengler encounter a possessed Janine, Mrs. Spengler doesn't hesitate for a second, instantly throwing and activating the Ghost Trap to help capture the spirit inside of her. Egon didn't even have to describe the trap or how it worked—his mom already knew what to do.
- While Egon deals with the Big Bad of the episode, Mrs. Spengler joins Janine and effortlessly uses more Ghost Traps and powerful, spirit-harming lights to save the other 'busters and Slimer.
- And finally, during the final battle against the evil spirit controlling the park, Mrs. Spengler is right there fighting alongside the team, controlling the Ecto-1's spirit-damaging headlights and causing the ghost great pain.
- The fact that Filmation revived their forgotten old "Ghost Busters" live-action series as a cartoon just so they would have the rights to the name, and that this show responded by calling themselves "The REAL Ghostbusters", is awesome in its sheer audacity.