In an episode of B.o.B Bob's daughter Trisha and a couple of the younger guys from Bob's office play Mystery Date in Bob's kitchen for lack of anything better to do.
In The Santa Clause Laura talks about how she always wanted that game and never got it as a kid. At the end of the first movie Scott gives her one when he finally accepts that he's the next Santa.
In an episode of The Simpsons, the family ends up playing the game after house swapping for the summer, and joke how the "dud" resembles Milhouse.
In an episode of Daria, Quinn dreams about her future college-related experiences in class where her suitors are: a cowboy, a surfer, and a preppy yacht type all calling back to the different dates offered in the game. They then fight over Quinn.
All New Series 4 of Wacky Packages featured a parody of the game titled "Misery Date". In the case of the parody, all the dates are duds (a hobo, a stereotypical nerd, and a scarred thug), as the girls futilely attempt to bar the door closed and run off.
