Unmarked spoilers are ahead, per Spoilers Off rule.

Zip's death. After he puts himself in the way of the demon's attack meant for Omar & Angel, he's fatally wounded, and his brother Toad can only shed tears as his brother dies in his arms. Luckily, Toad gets some payback against Mok by throwing him down into the portal to Hell, who summoned the demon that killed his brother.
Toad: Zip, what did ya do for?
Zip: For...for Uncle Mikey...and us. Toad, we ain't evil, are we?
Toad: Don't talk now, Zip. (Zip closes his eyes and dies in his arms) Zip? ZIP, TALK TO ME!!!

Tear Jerker / Rock and Rule