- The two bossfight against Ohatsu can be this, expecially the second, where she's possessed by the Genma Insects. The music is very sad too.
- Minokichi's (apparent) death is quite a low blow, but is how Jubei takes it that really sells it.
- Soki's final sacrifice. And again, Jubei's reaction to it.
Tear Jerker / Onimusha: Dawn of Dreams