When Spider-Man and his allies attempt to track down the missing and dangerous Lizard, they discover that Venom has returned to seek revenge on the Earth.
- And the Adventure Continues: The episode closes the series on Spider-Man and his amazing friends proposing to Tony Stark that they make a school for young heroes instead of him joining the Avengers.
- Back for the Finale: M.O.D.O.K. and most of the Avengers return for this episode.
- Freeze-Frame Bonus: If one looks at the scene where the World-Killer is destroyed, two of the Symbiote Sisters' hosts can be seen briefly.
- The Ghost: The Lizard and Swarm are mentioned in the first half of the episode, but don't physically appear.
- Grand Finale: This episode serves as the last one of the entire series.
- Last Episode, New Character: The Symbiote Sisters are introduced in this finale.
- Left Hanging: Despite being the final episode, there are still some loose ends, such as Swarm and the Lizard still on the run.
- Mythology Gag: Peter refers to considering whether or not to join the Avengers as 'The Stark Internship', which he used to refer to being Spider-Man in general in Spider-Man: Homecoming.
- Title Drop: Venom says the episode and season's title after he takes over Max's body.
- Trash the Set: Horizon High is destroyed by the World-Killer after it emerges from the portal.