Laser-Guided Karma is a central theme in these stories.
- In "The Seven," the Jack Russell terrier puppy picks on her Labrador retriever puppy friend, making her cry. She apologizes, vowing to protect the retriever from further teasing for as long as they're together; it turns out the two dogs are adopted into the same family, thus having the terrier keep this promise for the rest of their lives. Likely also applies to the puppy mill owner, a serial criminal who abandons his dogs and flees to a country which he hopes won't extradite him.
- In "The Survivor," Mittens's abusive adoptive family perishes in a fiery drunken driving car crash.
- In "The Seer," the five rats who threaten to kill and eat Mittens get chased off by Kelvin the Labradoodle. Kelvin also tells Mittens she will experience a comeuppance for shaking down his pigeon friends for food, with the implication that this indeed happens the next day when she first meets Bolt.
- In "The Blood Brother," Bolt's bigoted and murderous friend Duke is killed by a truck while chasing a cat into the road trying to get it run over. When Duke's equally prejudiced owner Frank posts hate speech messages on social media and shoots out the windows of his school with a gun, he is hauled into court, tried and convicted, and sentenced to a long stretch in the state's detention facility for minors.
- In "The Mall," the manager of Spender's Gifts, who has chased Mittens out of his store and the food court, decides to grab the cat so he can collect a reward for her return. His attempt to do so is foiled by Bolt, who scares him away while barking furiously.
- In "The Murder Mystery":
- Played with in "The Ski Trip." Bolt, Mittens, and Rhino ride up a chairlift without a ticket, snitch a pair of skis, erratically descend down a mountain trail while tearing up its freshly groomed surface, and engage in a snowball fight. They are banished to the hotel room for the last two days of the trip, but luckily find comedy movie marathons featuring the Marx Brothers and the Three Stooges on television to help pass the time.
- In "The Cakes," the pastry covered Bolt, Mittens, and Rhino frantically run for the doggy door after ruining Penny's mom's bake-sale goodies. Penny's mom is depicted chasing after them, with an implication that she will punish the three pets once she catches them.
- In "The Wind," Mary's angry, abusive current boyfriend Ike dies in a dog fight he picks with Bolt thanks to his own carelessness. Mary, Bolt's former girlfriend, is shown sliding back into her previous addictive and dissolute sexual behavior, with an implication that it will catch up to her sooner or later.
- Bolt and Penny have a bad interaction on the bus with Juanemma and her chihuahua Carmen in "The Service Dog," one where Bolt gets bitten on the nose. The perpetrators try to escape when Penny attempts to exchange contact information with them, but are located by a private investigator later on. And when Juanemma tries to lie about the incident during their court date with Judge Trudy, she's unsuccessful and has to pay damages to Penny for what they did.
- In "The Coyote," Bolt spares Charlie the Coyote's life when he catches the latter in his yard, letting him have a meal of leftovers from the garbage can and sending him on his way. The coyote returns the favor when he encounters Bolt lying injured on the road after falling during a conditioning run, luring a nearby farmer to where the dog is located so he can be taken to the vet.
- In "The Gift," the afterlife is Nirvana and based on Eastern karmic principles. Beings can’t enter until they have learned all their required life lessons.
