Plane Crazy Mickey speaking in nothing but squeaks and squawks in The Mickey Mouse 40th Anniversary Show is a bit jarring (even to Mickey himself), given how he typically has a voice in most media. However, it makes perfect sense from a meta/historical perspective, as this was exactly how Mickey spoke back in Plane Crazy and many of his earliest shorts, as he didn't have a proper voice until The Karnival Kid in 1929.
Fridge Logic
In the episode Mickey's 60th Birthday we see how the whole community of his friends, fans and producers experiences an awful breakdown whenever Mickey is missing, may it be a few days. Now in the comics, it happens extremely frequently that Mickey goes on a foreign adventure where he can't signal his position everyday to the whole planet, or that he is kidnapped by a villain such as Pete or the Phantom Blot. Does this mean the poor Mickey fans are supposed to be depressed every now and then ?