Helena Rosado spent most of her life married to a man who didn't truly love her.
Worse yet, she married a man who was the reason her son died. Despite denying it, when confronted by Risoleta and Vitória, Zico finally admits he planned to kill the first but accidentally led to his son's death.
It's also mentioned Zico cheated on her every now and then, but she always forgave him.
Seemingly runs in the family, as Candinha spent most of her life pining for Tibério, while in a loveless, at least from her, Arranged Marriage.
In the remake, Maria Aparadeira's family spent years thinking their daughter disappeared suddenly and was probably dead.
Professor Aristóbulo has seven (or six, depending on the iteration) sisters. He seemingly doesn't have contact with any of them, and he outright says its due to his condition.
