- The Espers' psychic forms as a car, rabbit, and bear in the anime during their attempt to assassinate Tetsuo symbolizes their true nature. Masaru being a car represents his polio disease, which leaves him unable to walk, and his reliance on a wheelchair to move. Kiyoko being a rabbit represents her being physically weaker than her friends (and because rabbits are frequently preyed on by larger animals) so she constantly relies on Takashi and Masaru to protect her. Takashi being a bear represents his quiet and pacifistic nature, but also his willingness to fight if his friends (especially Kiyoko) are threatened.
- The moment in the anime when Tetsuo is pushed over the edge and starts his journey into becoming a monster is when he and Kaori are ambushed and caught by the Clowns. Being outnumbered and outmuscled, he is utterly helpless and incapable of protecting either his girlfriend or Kaneda's bike. When Kaneda and the rest of the gang arrived and rescued them, it only further added to his humiliation and sense of impotence. From that moment onwards, he is determined to never be as weak and helpless again, hence his eager and destructive embrace of his newfound powers.