History Trivia / DallasBuyersClub

* StarDerailingRole: After Creator/JaredLeto won an Oscar for his work here, his career wound up faltering shortly afterwards. His public perception took a major nosedive when he played The Joker in ''Film/SuicideSquad'', where his performance was widely panned and his harassment of other actors in the name of method acting and similarly unprofessional behavior in complaining about the movie and trying to get ''Film/{{Joker|2019}}'' pulled. His reputation got even worse when he pulled an even more derided performance in the 2022 movie ''Film/{{Morbius|2022}}'', which quickly became an ironic internet meme for its poor critical reviews and box office performance. While he’s had the occasional success since, Leto's current popularity is a far cry from what it was only a few years ago when this movie came out.

* CrossCastRole: Cisgender man Creator/JaredLeto plays Rayon, a transgender woman. His performance earned him critical acclaim and numerous awards, though members of the LGBT community critized the casting choice as contributing to harmful sterotype that trans women are men in drag.

* CareerResurrection: For Creator/MatthewMcConaughey, as with his role he took home a Golden Globe and an Oscar. Roles in bigger films (''Film/TheWolfOfWallStreet'', ''Film/{{Interstellar}}'', ''WesternAnimation/{{Sing}}'', ''Film/TheGentlemen'') came to [=McConaughey=] after this film became a critical darling. It also marked Creator/JaredLeto's return to film acting after a five-year absence.

* CareerResurrection: For Creator/MatthewMcConaughey, as with his role he took home a Golden Globe and Oscar. It also marked Creator/JaredLeto's return to film acting after a five-year absence.

* YouMightRememberMeFrom: It might even involve reading the credits to notice that's [[Film/AfterHours Griffin]] [[Film/AnAmericanWerewolfInLondon Dunne]] under all that hair as Doctor Vass.

* CareerResurrection: For Creator/MatthewMcConaughey, as with his role he took home a Golden Globe and Oscar.

* WhatCouldHaveBeen: Woody Harrelson, Brad Pitt, and Ryan Gosling were considered for the part of Woodroff, in earlier versions of the film. [[Creator/DennisHopper Dennis Hopper]] was even slated to be behind the camera at one point.
* YouMightRememberMeFrom: It might even involve reading the credits to notice that's [[Film/AfterHours Griffin]] [[Film/AnAmericanWerewolfInLondon Dunne]] under all that hair as Doctor Vass.

* ScienceMarchesOn: AZT, the drug Ron rejects, is still used today in lower, less toxic doses. On the other hand, many of the drugs Ron sells are no longer used at all due to THEIR toxicity.

* WhatCouldHaveBeen : Woody Harrelson, Brad Pitt, and Ryan Gosling were considered for the part of Woodroff, in earlier versions of the film.

* HeyItsThatGuy: Yes, that's the lead singer of ThirtySecondsToMars as a woman.

* HeyItsThatGuy: Most notably, Woodroof is MatthewMcConaughey, and Rayon is Jared Leto, the lead singer of ThirtySecondsToMars!
** Bradford Cox, lead singer of the indie rock band Deerhunter, plays Rayon's boyfriend.
** [[TrueBlood Russell Edgington]] is Dr. Sevard.

* HeyItsThatGuy: Bradford Cox, lead singer of the indie rock band Deerhunter, plays Rayon's boyfriend.

* WhatCouldHaveBeen : Woody Harrelson, Brad Pitt, and Ryan Gosling were considered for the part of Woodroff, in earlier versions of the film.

* Hey,it'sthatguy!: Bradford Cox, lead singer of the indie rock band Deerhunter, plays Rayon's boyfriend.

* DyeingForYourArt: Both [=McConaughey=] and Leto lost a considerable amount of weight to play HIV patients.