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* Rocky in ''Webcomic/{{Lackadaisy}}'' was never exactly ''stable'', what with his habit of turning into an AxCrazy PyroManiac when under severe stress, but suffering a severe head injury from a car definitely didn't help matters.


** Karkat starts getting shades of this after a particularly brutal TraumaCongaLine. [[spoiler: Two of his friends were murdered in from of his eyes, two others are on killing sprees, he's dragging his newly-blinded friend's body (and accidentally drops him down some [[RunningGag stairs]], and he gets a message from his girlfriend, pronouncing the details of another murder - and when he tries to contact her, one of the AxCrazy trolls responds, hinting that she's been killed.]]

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** Karkat starts getting shades of this after a particularly brutal TraumaCongaLine. [[spoiler: Two of his friends were murdered in from front of his eyes, two others are on killing sprees, he's dragging his newly-blinded friend's body (and accidentally drops him down some [[RunningGag stairs]], and he gets a message from his girlfriend, pronouncing the details of another murder - and when he tries to contact her, one of the AxCrazy trolls responds, hinting that she's been killed.]]

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* In ''Webcomic/AwfulHospital'', [[BigBad The Parliament]] is slowly driving the doctors mad with a PerceptionFilter to ensure they are unable to fight back against or even notice the disease the Parliament is using to [[AssimilationPlot assimilate the current reality]] back into [[PiecesOfGod the original being]].


* In ''Webcomic/GirlGenius'' Gil's father [[spoiler:overlaying his own personality over a portion of Gil's mind]] and his [[spoiler:inheriting the responsibility of ruling his father's quickly crumbling empire]], combined with losing nearly every single friend and family member he had all at once, has not been kind to him and he's implied to have been in TheMadnessPlace for ''two and a half years''. All of Europe can tell there's something off with him.

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* In ''Webcomic/GirlGenius'' ''Webcomic/GirlGenius'', Gil's father [[spoiler:overlaying his own personality over a portion of Gil's mind]] and his [[spoiler:inheriting the responsibility of ruling his father's quickly crumbling empire]], combined with losing nearly every single friend and family member he had all at once, has not been kind to him and he's implied to have been in TheMadnessPlace for ''two and a half years''. All of Europe can tell there's something off with him.


* [[https://www.deviantart.com/onthemountaintop/art/My-Life-with-Asperger-s-588279880 "My Life with Asperger's"]] directly references this trope name when going onto the topic of having a meltdown.

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* [[https://www.deviantart.com/onthemountaintop/art/My-Life-with-Asperger-s-588279880 "My Life with Asperger's"]] directly references this trope name when going onto the topic of having a meltdown.meltdown.
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* Jack from ''Webcomic/GunnerkriggCourt''. He started off as a pretty normal guy, then he briefly got pulled into a DarkWorld and saw some ''very'' unpleasant things. Since then he became increasingly antisocial, paranoid (at one point he starves himself because he's convinced the Court has laced his food with nanobots to track him) and amoral (compare his treatment of the Laser Cows to his treatment of the Guard Robot). [[https://static.tvtropes.org/pmwiki/pub/images/Jack_Progress_7447.jpg Heck, even his appearance became worse over time]]. Fortunately, after [[spoiler:Zimmy removed the whitelegs from his head,]] he's gotten almost back to normal. Oh, and [[spoiler:[[TheCuckoolanderWasRight he was right]] [[ProperlyParanoid about the food]]]].

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* Jack from ''Webcomic/GunnerkriggCourt''.''Webcomic/GunnerkriggCourt'' (pictured on the main page). He started off as a pretty normal guy, then he briefly got pulled into a DarkWorld and saw some ''very'' unpleasant things. Since then he became increasingly antisocial, paranoid (at one point he starves himself because he's convinced the Court has laced his food with nanobots to track him) and amoral (compare his treatment of the Laser Cows to his treatment of the Guard Robot). [[https://static.tvtropes.org/pmwiki/pub/images/Jack_Progress_7447.jpg Heck, even his appearance became worse over time]]. Fortunately, after [[spoiler:Zimmy removed the whitelegs from his head,]] he's gotten almost back to normal. Oh, and [[spoiler:[[TheCuckoolanderWasRight he was right]] [[ProperlyParanoid about the food]]]].

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* Jack from ''Webcomic/GunnerkriggCourt''. He started off as a pretty normal guy, then he briefly got pulled into a DarkWorld and saw some ''very'' unpleasant things. Since then he became increasingly antisocial, paranoid (at one point he starves himself because he's convinced the Court has laced his food with nanobots to track him) and amoral (compare his treatment of the Laser Cows to his treatment of the Guard Robot). [[https://static.tvtropes.org/pmwiki/pub/images/Jack_Progress_7447.jpg Heck, even his appearance became worse over time]]. Fortunately, after [[spoiler:Zimmy removed the whitelegs from his head,]] he's gotten almost back to normal. Oh, and [[spoiler:[[TheCuckoolanderWasRight he was right]] [[ProperlyParanoid about the food]]]].
* Vaarsuvius spent most of "Don't Split The Party" undergoing this in ''Webcomic/TheOrderOfTheStick''. [[spoiler: They ultimately recovered but not before committing an act which may have completely crossed the MoralEventHorizon.]]
* Jin of ''Webcomic/WapsiSquare'' suffers from a bad case of this after [[spoiler:destroying the calendar machine. It was actually built at least partially for the purpose of keeping her sane]].
* ''Webcomic/{{Homestuck}}''--
** Karkat starts getting shades of this after a particularly brutal TraumaCongaLine. [[spoiler: Two of his friends were murdered in from of his eyes, two others are on killing sprees, he's dragging his newly-blinded friend's body (and accidentally drops him down some [[RunningGag stairs]], and he gets a message from his girlfriend, pronouncing the details of another murder - and when he tries to contact her, one of the AxCrazy trolls responds, hinting that she's been killed.]]
--> There. Good as new, best friend! It's like it never happened. No one can ever blame you for dropping him down the stairs now. Stairs? What stairs! Ha ha ha!
** Rose starts showing signs of it too, around the time [[spoiler: her mother died]].
* ''Webcomic/GarfieldMinusGarfield'': With no cat to give him sarcastic remarks, Jon Arbuckle slowly descends into madness. Examples include [[http://garfieldminusgarfield.net/post/27473059 smushing ice cream cones into his face]], [[http://garfieldminusgarfield.net/post/40406640 dressing up for a date... that's in three weeks]], ''[[http://garfieldminusgarfield.net/post/78032638 jumping in the streets wearing a party hat]]'', [[http://garfieldminusgarfield.net/post/81381173 chasing cars in the manner of dogs]], [[http://garfieldminusgarfield.net/post/503880743/try-g-g-in-book-form breaking]] [[http://garfieldminusgarfield.net/post/26654167 down]] sobbing at the most random times, [[http://garfieldminusgarfield.net/post/30759171 Madness Speak]], and, finally, [[http://garfieldminusgarfield.net/post/69159474 being sent to a Mental Hospital]].
* ''Webcomic/BittersweetCandyBowl'' has Lucy having a mental breakdown when Michael falls off a rock bridge while saving her.
* In ''Webcomic/{{Pacificators}}'', one of the best Pacificators they had, [[DisproportionateRetribution Castella]] [[HeWhoFightsMonsters Brandsford]], snapped and [[NightmareFuel murdered thousands of people]] before she was killed by a suicidal guy. Ever since, the regular people have hated the people who has [[ElementalPowers powers]], because they [[TearJerker fear another Castella Brandsford]].
* Happens to Benjamin Prester in ''Webcomic/AMiracleOfScience'' when [[spoiler: he believes that his partner Caprice has been killed]]. He becomes increasingly violent, and he starts acting more like he did in flashbacks - [[spoiler: when he had full-fledged ScienceRelatedMemeticDisorder]]. The two biggest clues are [[spoiler: he redoes his hair in a particular style when in MadScientist mode, and he introduces himself as Benjamin when fully sane but as Ben when in the throes of SRMD]].
* In ''Webcomic/DistortionNuzlocke'', Johnny goes through this more and more as the story goes on. He was already pretty messed up, but his fantasies cause him even more pain.
* Tekno slips in ''Webcomic/SonicTheComicOnline'' after her and Shortfuse become trapped in a dimension without modern technology. Tekno being a TeenGenius takes this very poorly and becomes more disheveled by the day. It comes to the point where she's writing manically on the walls and [[spoiler:she attempts to murder a villain by beating him to death]].
* In ''Webcomic/GirlGenius'' Gil's father [[spoiler:overlaying his own personality over a portion of Gil's mind]] and his [[spoiler:inheriting the responsibility of ruling his father's quickly crumbling empire]], combined with losing nearly every single friend and family member he had all at once, has not been kind to him and he's implied to have been in TheMadnessPlace for ''two and a half years''. All of Europe can tell there's something off with him.
* Bryce of ''Webcomic/WeAreTheWyrecats'' is falling victim to this due to a tumor in his brain.
* [[https://www.deviantart.com/onthemountaintop/art/My-Life-with-Asperger-s-588279880 "My Life with Asperger's"]] directly references this trope name when going onto the topic of having a meltdown.

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