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9* In ''Webcomic/AwfulHospital'', [[BigBad The Parliament]] is slowly driving the doctors mad with a PerceptionFilter to ensure they are unable to fight back against or even notice the disease the Parliament is using to [[AssimilationPlot assimilate the current reality]] back into [[PiecesOfGod the original being]].
10* ''Webcomic/BittersweetCandyBowl'' has Lucy having a mental breakdown when Michael falls off a rock bridge while saving her.
11* ''Webcomic/TheCroaking'': Del, after failing to kill his classmate Scra, failing to get his father's approval or sympathy, can't look in the mirror for fear of seeing the reflection of his father and starts to murmur [[MadnessMantra "sickening, sickening"]] whenever he sees Scra, or anything that reminds him of his [[FantasticRacism least favorite classmate]]. After getting kicked of the Aerial Combat team, his sanity degrades further: he starts living in a canyon and crafts a knife of stone to finally murder Scra ... [[spoiler:only to get killed in turn... [[NotQuiteDead sorta]]]].
12* In ''Webcomic/DistortionNuzlocke'', Johnny goes through this more and more as the story goes on. He was already pretty messed up, but his fantasies cause him even more pain.
13* In ''Webcomic/ElGoonishShive'', Pandora's decent into madness caused by her husband's untimely death is represented by her SignificantWardrobeShift at the end of the "Legacy" storyline.
14* ''Webcomic/GarfieldMinusGarfield'': With no cat to give him sarcastic remarks, Jon Arbuckle slowly descends into madness. Examples include [[http://garfieldminusgarfield.net/post/27473059 smushing ice cream cones into his face]], [[http://garfieldminusgarfield.net/post/40406640 dressing up for a date... that's in three weeks]], ''[[http://garfieldminusgarfield.net/post/78032638 jumping in the streets wearing a party hat]]'', [[http://garfieldminusgarfield.net/post/81381173 chasing cars in the manner of dogs]], [[http://garfieldminusgarfield.net/post/503880743/try-g-g-in-book-form breaking]] [[http://garfieldminusgarfield.net/post/26654167 down]] sobbing at the most random times, [[http://garfieldminusgarfield.net/post/30759171 Madness Speak]], and, finally, [[http://garfieldminusgarfield.net/post/69159474 being sent to a Mental Hospital]].
15* In ''Webcomic/GirlGenius'', Gil's father [[spoiler:overlaying his own personality over a portion of Gil's mind]] and his [[spoiler:inheriting the responsibility of ruling his father's quickly crumbling empire]], combined with losing nearly every single friend and family member he had all at once, has not been kind to him and he's implied to have been in TheMadnessPlace for ''two and a half years''. All of Europe can tell there's something off with him.
16* Jack from ''Webcomic/GunnerkriggCourt'' (pictured on the main page). He started off as a pretty normal guy, then he briefly got pulled into a DarkWorld and saw some ''very'' unpleasant things, [[GoMadFromTheRevelation causing him to become insane]]. Since then he became increasingly antisocial, paranoid (at one point he starves himself because he's convinced the Court has laced his food with nanobots to track him) and amoral (compare his treatment of the Laser Cows to his treatment of the Guard Robot). Not to mention, [[https://static.tvtropes.org/pmwiki/pub/images/Jack_Progress_7447.jpg even his appearance]] [[MadnessMakeover became worse over time]]. Fortunately, after [[spoiler:Zimmy removed the whitelegs from his head,]] he's gotten almost back to normal. Oh, and [[spoiler:[[TheCuckoolanderWasRight he was right]] [[ProperlyParanoid about the food]]]].
17* ''Webcomic/HighSchoolLessons'': The teachers at Westpoint High (or at least the ones who don't quit) either aren't normal to begin with or don't stay normal. One of them snapped after just a month and started painting the walls in fry sauce.
18* ''Webcomic/{{Homestuck}}'':
19** Karkat starts getting shades of this after a particularly brutal TraumaCongaLine. [[spoiler: Two of his friends were murdered in front of his eyes, two others are on killing sprees, he's dragging his newly-blinded friend's body (and accidentally drops him down some [[RunningGag stairs]]), and he gets a message from his girlfriend, pronouncing the details of another murder - and when he tries to contact her, one of the AxCrazy trolls responds, hinting that she's been killed.]]
20--> There. Good as new, best friend! It's like it never happened. No one can ever blame you for dropping him down the stairs now. Stairs? What stairs! Ha ha ha!
21** Rose starts showing signs of it too, around the time [[spoiler: her mother died]].
22* ''Webcomic/JackTheAmericanGhost'': While she wasn't that sane to begin with, Cindy definitely goes off the deep end by the end of the series, due to her being a LoonyFan for Jack while watching his growing relationship with Go-Eun.
23* Rocky in ''Webcomic/{{Lackadaisy}}'' was never exactly ''stable'', what with his habit of turning into an AxCrazy PyroManiac when under severe stress, but suffering a severe head injury from a car definitely didn't help matters.
24* Happens to Benjamin Prester in ''Webcomic/AMiracleOfScience'' when [[spoiler: he believes that his partner Caprice has been killed]]. He becomes increasingly violent, and he starts acting more like he did in flashbacks - [[spoiler: when he had full-fledged ScienceRelatedMemeticDisorder]]. The two biggest clues are [[spoiler: he redoes his hair in a particular style when in MadScientist mode, and he introduces himself as Benjamin when fully sane but as Ben when in the throes of SRMD]].
25* [[https://www.deviantart.com/onthemountaintop/art/My-Life-with-Asperger-s-588279880 "My Life with Asperger's"]] directly references this trope name when going onto the topic of having a meltdown.
26* Vaarsuvius spent most of "Don't Split The Party" undergoing this in ''Webcomic/TheOrderOfTheStick''. [[spoiler: They ultimately recovered but not before committing an act which may have completely crossed the MoralEventHorizon.]]
27* In ''Webcomic/{{Pacificators}}'', one of the best Pacificators they had, [[DisproportionateRetribution Castella]] [[HeWhoFightsMonsters Brandsford]], snapped and [[NightmareFuel murdered thousands of people]] before she was killed by a suicidal guy. Ever since, the regular people have hated the people who has [[ElementalPowers powers]], because they [[TearJerker fear another Castella Brandsford]].
28* Tekno slips in ''Webcomic/SonicTheComicOnline'' after her and Shortfuse become trapped in a dimension without modern technology. Tekno being a TeenGenius takes this very poorly and becomes more disheveled by the day. It comes to the point where she's writing manically on the walls and [[spoiler:she attempts to murder a villain by beating him to death]].
29* ''Webcomic/SweetHome2017'':
30** Hyein goes more and more crazy as time goes on, from a confident if a little bossy woman to a raving lunatic who tries to burn someone else alive in their sleep with a SlasherSmile. [[spoiler: After almost being raped by Gapsu and then believing that she'd killed an innocent woman, she completely loses any remnant of sanity she had left.]]
31** Ihyun starts as an AffablyEvil follower of Joon who, despite his loyalties, seems nice enough. [[spoiler: Then he kills the Tentacle Monster and makes it clear he may be the most insane one out of all of them.]]
32* ''Webcomic/{{Unsounded}}'':
33** Lemuel, in Duane's memories of their time in the army, was effected poorly by the horrors of war and feeling abandoned by his family. Despite being an amazing warrior Lem took more and more actions that were far from noble, [[https://www.casualvillain.com/Unsounded/comic/ch14/ch14_20.html like chopping up corpses while singing about killing the gods,]] culminating in burning a cart full of unarmed helpless prisoners. He got quite good at hiding his war crimes from authority figures.
34** By the time the comic starts Roger has spent fifteen years having his memories and soul dissolved so Crescian wrights can pick through it to figure out how to dismantle the Dammakhert. He is far from the princely noble rebel leader he was when Duane and Lemuel ran into him during the Foi-Hellick rebellion, though his fall started when he hit his DespairEventHorizon when forced to kill his lover in self defense.
35** Anadyne's despair at failing to save Stockyard, and accidentally decapitating him when she tried to rescue him is exacerbated by the First Silver. She lies despondent in the belly of the Silver Eel, until it merges with her and she ''tears off her own breast and shoves it in Stockyard's decaying head'', then walks into the night having become an avatar of pain and suffering and the face of a magical weapon of mass destruction.
36** Duane becomes more and more desperately obstinate about his brother being righteous as he's faced with evidence Lemuel was a war criminal who likely betrayed him to the assassins who arranged his death and zombification. In his vehement denial he starts acting less and less logically and lets Aldish soldiers into a shrine thinking they won't harm any children despite knowing soldiers are not always noble. This results in the deaths of several named characters and the main cast being fractured.
37* Jin of ''Webcomic/WapsiSquare'' suffers from a bad case of this after [[spoiler:destroying the calendar machine. It was actually built at least partially for the purpose of keeping her sane]].
38* Bryce of ''Webcomic/WeAreTheWyrecats'' is falling victim to this due to a tumour in his brain.

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