History Main / QuarantineWithExtremePrejudice

* ''WesternAnimation/{{Futurama}}'': In "Cold Warriors", Fry reintroduces the common cold centuries after it had been eradicated. So Planet Express headquarters is quarantined with a plastic wrap, but when the cold spreads through Manhattan, the entire island is put under a dome. And then it's removed altogether and sent to space to HurlItIntoTheSun. Our heroes must then find a cure before that happens.
* In ''WesternAnimation/CourageTheCowardlyDog'' episode "Conrad the Contaminationist", after the eponymous Conrad teaches Eustance and Muriel [[ThePigPen to live in filth]], the entire house is sealed in a giant doom as ordered by the City of Nowhere because "it's too dirty in there".

* In ''Series/DarkMatter2015'', an entire planet was quarantined when an attempt to create an immortality serum instead created highly infectious zombies. In "Episode 5", the crew take a job which involves boarding a ship that breached the quarantine and got themselves infected as a result.

* In ''Series/BabylonFive'' it's mentioned the Centauri are keeping the planet Nakaleen under a strict blockade, with orders to blow up any ship stupid enough to try to land or, worse, successfully landing and then taking off, due to the presence of the pseudo-sentient Nakaleen Feeders, that will drain any sentient of intelligence or infect them to create more Feeders, making a single Feeder getting off-world a danger on a galactic scale. While the Centauri have developed protocols to keep single Feeders contained and isolate infect subjects, [[ProperlyParanoid they know better than to take the risk]].
* In ''Series/DarkMatter2015'', an entire planet was quarantined when an attempt to create an immortality serum instead created highly infectious zombies. The crew take a job which involves boarding a ship that breached the quarantine and got themselves infected as a result.

* ''Film/ResidentEvil'' series. In ''Film/ResidentEvilApocalypse'', Umbrella Corporation decides to quarantine Raccoon City as the T-Virus escapes the Hive. As a priority, they evacuate Umbrella [=VIPs=] when the zombies reach the blockade, then start shooting everything in sight. In the first film, The Hive's security instantly locks down the entire facility and kills everyone inside to contain the T-Virus... Even though a self-contained, sealed air circulation system could have done the same thing with a far smaller losses of personnel and equipment (Umbrella is infamously StupidEvil in both the movie and video game continuities, but are even worse about it in the films).

* ''VideoGame/InFamous'' is set during one of these quarantines where FEMA has the entire island under lockdown due to the sudden spread of an infectious illness [[spoiler: which is actually radiation sickness]]. Although it's less to do with protecting citizens as much is it about keeping a WeaponOfMassDestruction from escaping the city until they reclaim it.

** Especially awful villains go to the Birdcage, an ultra prison designed so that nobody leaves, ever. The whole complex is suspended inside a hollowed mountain, which is a perfect vacuum and guarded by an army of drones. Any attempt to breach the walls, even with super powers, will cause the whole complex to suffocate and the drones to start shooting whoever's left. The mountain is also hardened against electricity and radiation to ensure no communication. Prisoners get monthly deliveries of newspapers, food, uniforms, and novels, but otherwise must fend for themselves.

* ''WesternAnimation/{{Grojband}}'': When Corey gets the chicken pox in "Pox N' Roll", Trina alerts the Mayor who seals the place in an outbreak dome - with Trina still inside. The Mayor posts tanks outside the bubble to make sure no one tries to escape.

* In ''Manga/OnePiece'', there was a kingdom that had a massive mine of "Amber Lead", a material that was considered very desirable... except that it was actually highly poisonous and ended up killing the entire population. And then the neighboring countries mistook Amber Lead poisoning for contagious and started indiscriminately killing everyone who tried to leave. Well, except for the royal family and high-ranked nobles, who managed to escape before the crisis went really bad. [[KarmaHoudini These include the people who most actively sought out the Amber Lead.]] [[CrapsackWorld Of course.]]\\\
Doesn't end there. In their desperation, those who had yet to die of the illness took arms with weapons made of the very mineral that was killing them and attempted to break through the quarantine for treatment. The surrounding countries took it as a declaration of war and sent their armies to '''decimate the population and burn the country of Flevance to the ground'''. Only the then 10 year-old Trafalgar Law managed to evade military forces and escape genocide.

* In a COVID-19 themed short of ''WebAnimation/TheMostPopularGirlsInSchool'', Shay is quarantined to her bedroom against her will because her family believes she has the virus after she had coughed once the previous day.

* ''Film/TheRezort'': The army's only countermeasure to the zombies of the titular resort escaping their enclosures is to napalm the whole island to kingdom come, without even trying to save anybody still inside.

* ''Film/ScoutsGuideToTheZombieApocalypse'' has a variation of this, in that the military in this movie are so desperate to contain the zombie virus that they'll firebomb the town to do so.

** Mention is made of other extant threats that are quarantined to specific areas because they're too powerful and hostile to destroy or apprehend. One example is Nilbog, a supervillain capable of creating intelligent lifeforms and entire ecosystems, who is quarantined within Ellisburg, New York.

** Any city attacked by the Simurgh is quarantined once she's driven away, because the Simurgh uses a combination of future sight, telepathy, and induced psychosis to turn people she interacts with into DisasterDominos that will cause more disasters months or years down the line. People attempting to leave the affected city without very rare authorization are shot on sight, and those that are permitted to leave are tattooed to ensure everyone knows they're a potential hazard.

* ''Literature/{{Worm}}'': Especially awful villains go to the Birdcage, an ultra prison designed so that nobody leaves, ever. The whole complex is suspended inside a hollowed mountain, which is a perfect vacuum and guarded by an army of drones. Any attempt to breach the walls, even with super powers, will cause the whole complex to suffocate and the drones to start shooting whoever's left. The mountain is also hardened against electricity and radiation to ensure no communication. Prisoners get monthly deliveries of newspapers, food, uniforms, and novels, but otherwise must fend for themselves.

* In ''Series/TwentyFour'', on Day 3 terrorists manage to get their hands on a airborne virus and release it into a hotel, turning anyone inside into a potential carrier. CTU enacts a quarantine of the hotel to prevent the virus from spreading and Michelle Dessler is forced to shoot a man who tries to flee after being warned not to. Most of the hotel residents later opt to take suicide capsules offered to them to be spared a horrible death. [[ShootTheShaggyDog Oh, and the virus gets out anyway.]]

* In ''Literature/TheLostFleet'' series, the fleet charged with isolating the moon Europa and the engineered disease accidentally created on it have standing orders to destroy any ship that lands on the moon so it can't take off if they can't prevent it from landing. If the quarantine is broken and a ship does make it off and gets back to Earth or the the colonies on Mars, the fleet is to destroy everything man-made in the solar system that could possibly take the virus elsewhere, annihilate all life on Mars and on Earth, and then hurl itself into the sun.

* ''Film/{{Outbreak}}'' has the U.S. military using this option to stop the disease, culminating with blowing up the town with a massive blockbuster. Played with because the GeneralRipper behind the quarantine wants the disease as a bio-weapon and this cannot be done if its publicly known that there is a cure.

* ''Webcomic/StandStillStaySilent'': In the JustBeforeTheEnd prologue, Iceland, the first nation to close its borders to protect itself from ThePlague, is shown having its coast guard gunning down boats of refugees. The focus character of the segment showing this happening is a radar reader starting to get BadDreams and deciding to quit [[CallToAgriculture to become a sheep herder]].

* Scout's Guide to the Zombie Apocalypse has a variation of this, in that the military in this movie are so desperate to contain the zombie virus that they'll firebomb the town to do so.

* Most Resident Evil games involves this, in that most involve either a military faction or a corporation desperately trying to contain a viral outbreak that creates monsters.

SubTrope of GodzillaThreshold. Compare TheOnlyWayToBeSure, in which the entire population in the quarantined area is eliminated, as opposed to only those who are trying to escape. Contrast NoFEMAResponse, where a disastrous situation is bad enough that even ''this'' type of response would be justified (and maybe even accepted), but circumstances make it flat-out impossible.