History Main / QuarantineWithExtremePrejudice

** The entirety of Manhattan Island is made into a prison, and thousands of convicts run around among the ruins preying upon each other. The opening scene shows a few convicts trying to circumvent the wall on a raft. A gunship helicopter spotlights them and issues one warning to turn back. When the response is unsatisfactory, the men and their raft are liquefied by gunfire. Given what we see of the city-turned-prison camp during the rest of the film, this might well cross over with [[SuicideByCop another trope entirely]]. The novelization turns this trope even more literal by mentioning the fact the government exploited the fact the city was hit with a massive nerve gas attack to justify blocking off the city to begin with -- turning it into a Penitentiary was just the natural evolution of that.

* ''Film/ResidentEvilFilmSeries'': In ''Film/ResidentEvilApocalypse'', Umbrella Corporation decides to quarantine Raccoon City as the T-Virus escapes the Hive. As a priority, they evacuate Umbrella [=VIPs=] when the zombies reach the blockade, then start shooting everything in sight. In the [[Film/ResidentEvil2002 first film]], The Hive's security instantly locks down the entire facility and kills everyone inside to contain the T-Virus... Even though a self-contained, sealed air circulation system could have done the same thing with far smaller losses of personnel and equipment (Umbrella is infamously StupidEvil in both the movie and video game continuities, but are even worse about it in the films).

* An early sidequest in ''Videogame/AssassinsCreedOdyssey'' involves a village that's been razed due to a plague, with the Misthios encountering a priest attempting to kill a family of survivors. They have the option of either attempting to save the family or letting the priest finish the job. [[spoiler:Doing the latter will result in Kephallonia being wiped out by the plague]].

* It's a minor plot point in ''VideoGame/DeadSpace1''. The automatic system of the ship the game takes place in treats the [[NotUsingtheZWord not-quite-zombies "necromorphs"]] as an unknown infection it must contain. Unfortunately, this mostly just slows down the protagonist since necromorphs can access the ventilation system.

** The first game is set during one of these quarantines where FEMA has the entire island under lockdown due to the sudden spread of an infectious illness [[spoiler:which is actually radiation sickness]]. Although it's less to do with protecting citizens as much is it about keeping a WeaponOfMassDestruction from escaping the city until they reclaim it.
** In ''VideoGame/InfamousSecondSon'', Augustine and the DUP set up shop in UsefulNotes/{{Seattle}} in the hopes of recapturing a group of [[DifferentlyPoweredIndividual conduits]] that have escaped their custody and had escaped into the town. She uses her powers over concrete to block or demolish all means of entering or exiting the city, heavily regulating the citizen's daily lives under her draconian rule in a twisted sense of ensuring safety. [[spoiler:It is then revealed that Augustine had allowed the conduits to escape as a gambit to show that her agency was still useful, staging the entire reason for the quarantine.]]

* In the prologue of ''VideoGame/TheLastOfUs'', a soldier holds Joel and his daughter Sarah at gunpoint as they try to escape the Infected-overrun city. The soldier confers with his CO over the radio over the pair of civilians... and then reluctantly opens fire. The suggestion being that the military is gunning down ''everyone'' fleeing the city, as this is when the Infection was brand-new, everyone was panicked, and they didn't have reliable ways of detecting {{Zombie Infectee}}s just yet.
* You see the aftermath of this in ''VideoGame/Left4Dead2'', in New Orleans. When passing through an abandoned checkpoint, one of the characters points out that many of the bodies laid about were not zombified when they died. Implying that the military gunned them down to try and hold quarantine.

* Most ''VideoGame/ResidentEvil'' games involve this, in that most involve either a military faction or a corporation desperately trying to contain a viral outbreak that creates monsters.

* In the backstory to ''VideoGame/StarTrekOnline'' a bloodfire epidemic broke out on the Romulan planet Kevratas, and Praetor Taris ordered the navy to blockade the planet as a quarantine measure. However, General Tebok {{defied|Trope}} Taris' order to put down the subsequent revolt by force, starting a long-running power struggle that eventually led to the navy overthrowing Taris and installing Sela as praetor.
* ''VideoGame/StarWarsTheOldRepublic'': The Rakghoul plague from the first game hasn't gone away, and the contest over what was left of Taris allowed it to get off-world, leading to periodic outbreaks on various planets. An announcement on the Imperial spaceport on an inflicted planet will be [[BrutalHonesty up front]] with the situation, telling any Imperial citizen that has been infected to turn themselves in immediately to be killed and their body incinerated.

* ''Film/{{Pontypool}}'' has a town infected with a virus that has infected the English language. The military decides to bomb it when almost everyone in it has succumbed to it. [[spoiler: It doesn't work and soon infects a news anchor of the BBC, thus possibly dooming the entire English-speaking world population.]]

* It's a minor plot point in ''VideoGame/DeadSpace''. The automatic system of the ship the game takes place in treats the [[NotUsingtheZWord not-quite-zombies "necromorphs"]] as an unknown infection it must contain. Unfortunately, this mostly just slows down the protagonist since necromorphs can access the ventilation system.

* ''VideoGame/KnightsOfTheOldRepublic'' Rakghoul plague, an affliction native to Taris that turns its victims into horrible, mutated creatures has been confined to the Undercity, but any Outcasts (resident of the Undercity) who become a ZombieInfectee is locked away in a cage with others like them in the hope that when the mutation takes hold that they'll kill each other. A kindly doctor in the Upper City found a cure but the Sith confiscated his samples and notes. [[spoiler: You can get a sample he can use to make a vaccine and serum to cure infected people, but it's AllForNothing as Malak gets trigger happy and carpet bombs the planet]]

* ''VideoGame/PlagueInc'': If things get bad enough, governments can start bombing infected cities. Unfortunately for humanity, they tend to only resort to this after your plague has gotten completely out of control; so unless you're playing Mega-Brutal and that buys them just enough time to finish the cure, it's not gonna save them.

* In ''WesternAnimation/CourageTheCowardlyDog'' episode "Conrad the Contaminationist", after the eponymous Conrad teaches Eustance and Muriel [[ThePigPen to live in filth]], the entire house is sealed in a giant doom as ordered by the City of Nowhere because "it's too dirty in there".
* ''WesternAnimation/{{Futurama}}'': In "Cold Warriors", Fry reintroduces the common cold centuries after it had been eradicated. So Planet Express headquarters is quarantined with a plastic wrap, but when the cold spreads through Manhattan, the entire island is put under a dome. And then it's removed altogether and sent to space to HurlItIntoTheSun. Our heroes must then find a cure before that happens.

* ''WesternAnimation/SpongebobSquarepants'': When the Krusty Krab goes under quarantine in "Kwarantined Krab", Plankton tries to escape and immediately gets burned to a crisp by a quarantine enforcer. [[UnexplainedRecovery He comes back without explanation in the ending]].

* In 2014, a politician suggested this method of handling any case of Ebola discovered on American soil or elsewhere. His ExactWords as tweeted: "People with Ebola need to be humanely put down immediately. The protocol for a positive Ebola test should be immediate humane execution and sanitization of the whole area. That will save lives. It's mathematical. Do whatever saves the most lives. But here's a fact: treating Ebola patients kills more innocent people. There's just no other way with Ebola. We need to be napalming villages from the air right now." Fortunately the epidemic was eventually brought under control without resorting to such extreme measures, and there is now [[https://www.cnbc.com/2019/07/09/mercks-ebola-vaccine-helps-combat-deadly-outbreak-in-the-congo.html a vaccine for Ebola]] that, while still undergoing trials, had such initially effective results in preventing Ebola that it is now being used in the field while awaiting full trial completion and licensing.

* ''Series/StarTrekDeepSpaceNine'': A variant in the two-part episode "[[Recap/StarTrekDeepSpaceNineS03E11PastTensePartI Past]] [[Recap/StarTrekDeepSpaceNineS03E12PastTensePartII Tense]]"; before the year 2024, the government repealed the real-life Employment Act of 1946. Sanctuary Districts were created to help those unemployed find jobs. Unfortunately, not only did the conditions inside the districts quickly deteriorate, but the repealing of the act made unemployment and homelessness essentially illegal. The undesirables of society (i.e., the woefully homeless, the mentally ill, the criminally violent, etc.) were shoved under the rug, into these districts, and were not allowed to leave. Outside the districts, society was prim, proper, and clean. In the fictional history of Star Trek, what led to the abolishment of the districts was an uprising by Los Angeles district denizen Gabriel Bell, who fought for better conditions and treatment. A rumor spread that the district bureaucracy workers had been killed in a firefight, and fortified law enforcement stormed the processing center, killing all of the protestors. As it turned out, none of the workers had been harmed, and public opinion on the Sanctuary Districts immediately changed. In the episode, Sisko and Bashir end up in the Los Angeles district. They attempt to avoid interfering with history, but they become involved when Bell, by chance, is killed while coming to their defense, and to get back to their own proper time, Sisko, takes up Bell's identity...