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* The third book of the ''Literature/{{Spaceforce}}'' series, ''Oblivion'', centers around a drug of the same name. Oblivion induces a lucid dreaming state in users, allowing them to experience a fantasy scenario of their choice -- innocent or less so. Unfortunately, it can also cause users to return to the dream state without warning and at random days or weeks later, often causing fatal accidents.

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* The third book of the ''Literature/{{Spaceforce}}'' ''Literature/Spaceforce2012'' series, ''Oblivion'', centers around a drug of the same name. Oblivion induces a lucid dreaming state in users, allowing them to experience a fantasy scenario of their choice -- innocent or less so. Unfortunately, it can also cause users to return to the dream state without warning and at random days or weeks later, often causing fatal accidents.

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* ''Literature/TheShipWho'': ''[=PartnerShip=]'' has several designer drugs, including Blissto and Seductron. The latter, rather than being an aphrodesiac, makes people very stupid and suggestible to the point where a CorruptCorporateExecutive doses an employee who wants a cut of his profits with it and tells him to walk, unsuited, into a room full of [[NamesToRunAwayFromVeryFast Ganglicide vapor]]. Alpha, a ClandestineChemist working at a drug rehab clinic, likes to dose charity patients addicted to Blissto with a variant of that drug that seemingly cures them, only to inform them that they'll die if not regularly dosed, all the better to have minions who value her life highly.

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* ''Literature/TheShipWho'': ''Literature/TheShipWho'':
** ''Dramatic Mission'' describes "mindtrap", a mind-expanding drug considered harmless and mainly useful for helping to retain memory. An older actor who can't afford memory loss has been taking such a high dose for so long that it's softened his bones and left him with chronic fatigue and pain.
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''[=PartnerShip=]'' has several designer drugs, including Blissto and Seductron. The latter, rather than being an aphrodesiac, makes people very stupid and suggestible to the point where a CorruptCorporateExecutive doses an employee who wants a cut of his profits with it and tells him to walk, unsuited, into a room full of [[NamesToRunAwayFromVeryFast Ganglicide vapor]]. Alpha, a ClandestineChemist working at a drug rehab clinic, likes to dose charity patients addicted to Blissto with a variant of that drug that seemingly cures them, only to inform them that they'll die if not regularly dosed, all the better to have minions who value her life highly.
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* ''Literature/TheShipWho'': ''[=PartnerShip=]'' has several designer drugs, including Blissto and Seductron.

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* ''Literature/TheShipWho'': ''[=PartnerShip=]'' has several designer drugs, including Blissto and Seductron. The latter, rather than being an aphrodesiac, makes people very stupid and suggestible to the point where a CorruptCorporateExecutive doses an employee who wants a cut of his profits with it and tells him to walk, unsuited, into a room full of [[NamesToRunAwayFromVeryFast Ganglicide vapor]]. Alpha, a ClandestineChemist working at a drug rehab clinic, likes to dose charity patients addicted to Blissto with a variant of that drug that seemingly cures them, only to inform them that they'll die if not regularly dosed, all the better to have minions who value her life highly.
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* ''VideoGame/{{Starfield}}'' has a wide variety of stat-boosting drugs, some stated to be addictive, others with undisclosed side effects. For example, Heart+ briefly improves health and damage resistance, but if you take too much, then your carrying capacity drops.
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One F in Film.


* Played with in ''FFilm/Transformers2007'' when a police detective accuses Sam of partaking in "mojo", which he assumes is a designer drug. "Mojo" is the name of the family's chihuahua, and the drugs are said dog's painkillers.

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* Played with in ''FFilm/Transformers2007'' ''Film/Transformers2007'' when a police detective accuses Sam of partaking in "mojo", which he assumes is a designer drug. "Mojo" is the name of the family's chihuahua, and the drugs are said dog's painkillers.
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* In ''Film/RepoTheGeneticOpera'' [=GeneCo=], the company that makes artificial organs and cosmetic surgery, also sells a highly addictive painkiller called Zydrate that is used in its surgeries. It comes in a little glass vial[[note]] A little glass vial?[[/note]] and glows blue. LovableRogue Graverobber sells black market Zydrate that he extracts from the brains of corpses.

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* In ''Film/RepoTheGeneticOpera'' ''Film/RepoTheGeneticOpera'': [=GeneCo=], the company that makes artificial organs and cosmetic surgery, also sells a highly addictive painkiller called Zydrate that is used in its surgeries. It comes in a little glass vial[[note]] A little glass vial?[[/note]] and glows blue. LovableRogue Graverobber sells black market Zydrate that he extracts from the brains of corpses.
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* ''Manga/The100GirlfriendsWhoReallyReallyReallyReallyReallyLoveYou'': Kusuri’s family specializes in creating drugs that can do almost anything, from reversing aging to growing body parts to switching bodies, just to name a few.
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* ''Fanfic/AYoungGirlsGuerrillaWar'': Once stuck in a position of leadership, Tanya's magic becomes this: constant use of mental stimulation spells results in something similar to wartime usage of amphetamines due to her refusal to take any time off.
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* ''VideoGame/{{Rimworld}}'': The game includes some real drugs [[CallARabbitASmeerp with new names]], but also Luciferium, which can heal permanent injuries and chronic health conditions that are untreatable with other medicine, but the pawn has to take it for the rest of their life, which will be [[NumberOfTheBeast 6.66 days]] if another dose isn't consumed.
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* An odd variation with [[https://en.wikipedia.org/wiki/Adrenochrome adrenochrome]]. While it is a real chemical compound, created when adrenaline comes into contact with oxygen, a conspiracy theory arose in the late 2010s falsely claiming that it was an incredibly powerful hallucinogen procured by extracting children's adrenal glands.[[note]]While adrenochrome is very mildly hallucinogenic, ingesting it causes mild depressed feelings, making it undesirable as a recreational drug. It's also childishly simple to synthesize, anyway: most of what you would need can be found in an epi pen.[[/note]]

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* An odd variation with [[https://en.wikipedia.org/wiki/Adrenochrome adrenochrome]]. While it is a real chemical compound, created when adrenaline comes into contact with oxygen, a conspiracy theory arose in the late 2010s falsely claiming that it was an incredibly powerful hallucinogen procured by extracting children's adrenal glands.[[note]]While adrenochrome is very mildly hallucinogenic, ingesting it causes mild depressed feelings, making it undesirable as a recreational drug. It's also childishly simple to synthesize, anyway: most of what you would need can be found in an epi pen.[[/note]][[/note]] The urban legend is most likely based on the portrayal in ''Film/FearAndLoathingInLasVegas''.
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* ''Film/FearAndLoathingInLasVegas'': Adrenochrome, which is a real compound, but its effects and method of production are fictionalized.
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* ''WesternAnimation/Sealab2021'': Stimutacs, from the episode of the same name, are a fictional drug derived from the venom of the fugu invented by Sparks to make an assload of cash. HilarityEnsues.

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* ''WesternAnimation/Sealab2021'': Stimutacs, from the episode of the same name, are a fictional drug derived from the venom of the fugu invented by Sparks to make an assload of cash. HilarityEnsues.
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* ''Literature/{{Otherland}}'' has "charge", which is taken through electronic implants.
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* The Appalachian town of ''ComicBook/SilkHills'' is home to moth dust, an intense psychoactive hallucinagen made, possibly entirely, from the poisonous scales of a local species of moth. Townies are known to lace their weed with it for recreational use, but the moths' underground nests are absolutely covered in the stuff, causing random, unexpected hallucinations and [[TraumaButton traumatic flashbacks]]. Celia, when completely covered with moths, [[HigherUnderstandingThroughDrugs hallucinates an encounter with a divine moth being]].
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* ''Series/KamenRiderFourze'' follows up the above example with the Astro Switches used by [[MonsterOfTheWeek Zodiarts]]. Like Gaia Memories, the Switches are distributed to high schoolers by the villains, and their use is shown to result in addiction and insanity. In one episode, a previous Astro Switch user is shown having withdrawal symptoms, refusing to go to school out of fear of receiving another Switch and having a relapse.
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* ''WebOriginal/LoomingGaia'' [[https://loominggaia.tumblr.com/post/639080335468068864/recreational-drugs-of-looming-gaia-lore-under has its own drugs]]. Most of them have relatively mundane places of origin and effects, but there's also a couple more fantastic ones, such as pyre crystals, which grow in [[OurNymphsAreDifferent pyriad]] corpses and that are made into dust that red elves can swallow to get high, and [[MagicMushroom blue-eye shrooms]], which cause a random magical effect on whoever eats them.

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* ''WebOriginal/LoomingGaia'' ''Literature/LoomingGaia'' [[https://loominggaia.tumblr.com/post/639080335468068864/recreational-drugs-of-looming-gaia-lore-under has its own drugs]]. Most of them have relatively mundane places of origin and effects, but there's also a couple more fantastic ones, such as pyre crystals, which grow in [[OurNymphsAreDifferent pyriad]] corpses and that are made into dust that red elves can swallow to get high, and [[MagicMushroom blue-eye shrooms]], which cause a random magical effect on whoever eats them.
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* In ''Literature/MissPeregrinesHomeForPeculiarChildren'', there is "Ambrosia", an oily, black fluid that when poured into a peculiar's eyes, lets out a scorching beam of light, and after fading, temporarily increases the strength of their powers. After wearing off, it leaves the user drained and temporarily blinded, with their powers permanently weakening after enough doses. Chronic users wear masks, [[spoiler:as the hot rays from their eyes melt their skin over time, leaving their faces disfigured]]. Additionally [[spoiler:the drug is made from the [[SoulPoweredEngine second soul]] of peculiars]]

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* In ''Literature/MissPeregrinesHomeForPeculiarChildren'', there is "Ambrosia", an oily, black fluid that when poured into a peculiar's eyes, lets out a scorching beam of light, and after fading, temporarily increases the strength of their powers. After wearing off, it leaves the user drained and temporarily blinded, with their powers permanently weakening after enough doses. Chronic users wear masks, [[spoiler:as the hot rays from their eyes melt their skin over time, leaving their faces disfigured]]. Additionally [[spoiler:the drug is made from the [[SoulPoweredEngine second soul]] of peculiars]]
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* In ''Literature/MissPeregrinesHomeForPeculiarChildren'', there is "Ambrosia", an oily black fluid that when poured into a peculiar's eyes, lets out a scorching beam of light, and after fading, temporarily increases the strength of their powers. After wearing off, it leaves the user drained and temporarily blinded, with their powers permanently weakening after enough doses. Chronic users wear masks, [[spoiler:as the hot rays from their eyes melt their skin over time, leaving their faces disfigured]]. Later we find out the drug [[spoiler:is made from the [[Soul-PoweredEngine second soul]] of peculiars]]

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* In ''Literature/MissPeregrinesHomeForPeculiarChildren'', there is "Ambrosia", an oily oily, black fluid that when poured into a peculiar's eyes, lets out a scorching beam of light, and after fading, temporarily increases the strength of their powers. After wearing off, it leaves the user drained and temporarily blinded, with their powers permanently weakening after enough doses. Chronic users wear masks, [[spoiler:as the hot rays from their eyes melt their skin over time, leaving their faces disfigured]]. Later we find out the Additionally [[spoiler:the drug [[spoiler:is is made from the [[Soul-PoweredEngine [[SoulPoweredEngine second soul]] of peculiars]]
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* In ''Literature/MissPeregrinesHomeForPeculiarChildren'', there is "Ambrosia", an oily black fluid that when poured into a peculiar's eyes, lets out a scorching beam of light, and after fading, temporarily increases the strength of their powers. After wearing off, it leaves the user drained and temporarily blinded, with their powers permanently weakening after enough doses. Chronic users wear masks, [[spoiler:as the hot rays from their eyes melt their skin over time, leaving their faces disfigured]]. Later we find out the drug [[spoiler:is made from the [[Soul-PoweredEngine second soul]] of peculiars]]
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* ''Series/{{Arrowverse}}'':

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* ''Series/{{Arrowverse}}'':''Franchise/{{Arrowverse}}'':
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Moved to Website/


* Since the only law in the titular city of ''WebOriginal/{{Mortasheen}}'' is "Chaos Reigns", then it should come as no surprise that a few of the game's {{Mon}}s are made for producing these. Aside from [[http://www.bogleech.com/mortasheen/daemonut.htm the two]] [[http://www.bogleech.com/mortasheen/grimbrosia.htm plant-based ones]], there's also the [[http://www.bogleech.com/mortasheen/crepusculent.htm Crepusclent]], which secretes psychotropic worms that induce ludicrously powerful PsychicPowers, but also [[MushroomSamba causes very vivid hallucinations]]. There's also [[http://www.bogleech.com/mortasheen/jitter.htm Jitter]], who has tumorous drug-producing glands in its head that make it "a viable alternative to the coffee machine". Unfortunately, due to these glands, they're pretty much all insane.

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* Since the only law in the titular city of ''WebOriginal/{{Mortasheen}}'' ''Website/{{Mortasheen}}'' is "Chaos Reigns", then it should come as no surprise that a few of the game's {{Mon}}s are made for producing these. Aside from [[http://www.bogleech.com/mortasheen/daemonut.htm the two]] [[http://www.bogleech.com/mortasheen/grimbrosia.htm plant-based ones]], there's also the [[http://www.bogleech.com/mortasheen/crepusculent.htm Crepusclent]], which secretes psychotropic worms that induce ludicrously powerful PsychicPowers, but also [[MushroomSamba causes very vivid hallucinations]]. There's also [[http://www.bogleech.com/mortasheen/jitter.htm Jitter]], who has tumorous drug-producing glands in its head that make it "a viable alternative to the coffee machine". Unfortunately, due to these glands, they're pretty much all insane.
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* ''WesternAnimation/BatmanTheAnimatedSeries'' has Renuyu, a face cream that makes the user's skin like putty and allows them to shape it in any way they desire but is extremely habit-forming. After actor Matt Hagen was disfigured in a car accident, CorruptCorporateExecutive Roland Daggett offered him Renuyu in place of plastic surgery and took advantage of his addiction to get him to commit crimes for him [[MasterOfDisguise disguised as other people]] which eventually led to him becoming Clayface.

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* The ''WesternAnimation/BatmanTheAnimatedSeries'' two-parter "[[Recap/BatmanTheAnimatedSeriesE20FeatOfClayPart1 Feat of Clay: Part 1]]/[[Recap/BatmanTheAnimatedSeriesE21FeatOfClayPart2 Part 2]]" has Renuyu, a face cream that makes the user's skin like putty and allows them to shape it in any way they desire but is extremely habit-forming. After actor Matt Hagen was disfigured in a car accident, CorruptCorporateExecutive Roland Daggett offered him Renuyu in place of plastic surgery and took advantage of his addiction to get him to commit crimes for him [[MasterOfDisguise disguised as other people]] which eventually led leads to him becoming Clayface.



* The ''WesternAnimation/DoubleDragon1993'' animated series gives us RPM, a drug that turns its users into hulking blue monsters with super strength. The Shadow Master was able to make it out of a natural alien substance called Black Fungus.
* An episode of Creator/{{ABC}}'s version of ''WesternAnimation/{{Doug}}'' had a tobacco analogue called Nic-Nacs, which could cause people's mouths to freeze up.

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* The ''WesternAnimation/DoubleDragon1993'' animated series gives us RPM, a drug that turns its users into hulking blue monsters with super strength. The Shadow Master was able to make it out of a natural alien substance called Black Fungus.
* An episode of Creator/{{ABC}}'s version of ''WesternAnimation/{{Doug}}'' had has a tobacco analogue called Nic-Nacs, which could can cause people's mouths to freeze up.
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* ''WesternAnimation/CaptainPlanetAndThePlaneteers'' did this trope with an anti-drug episode, "Mind Pollution", where the drug in question (oh-so-creatively called "Bliss") turns its victims into strung-out hollow-eyed zombies. Like "Bravestarr" sample above, [[spoiler:Linka's cousin Boris dies]]. The episode even calls it a "new designer drug".

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* ''WesternAnimation/CaptainPlanetAndThePlaneteers'' did does this trope with an anti-drug episode, "Mind Pollution", where "[[Recap/CaptainPlanetAndThePlaneteersS2E1MindPollution Mind Pollution]]", in which the drug in question (oh-so-creatively called "Bliss") turns its victims into strung-out hollow-eyed zombies. Like "Bravestarr" sample the ''Bravestarr'' example above, [[spoiler:Linka's cousin Boris dies]]. The episode even calls it a "new designer drug".

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Alphabetization


* The ingredient you get for helping Lil' Smoke in ''VideoGame/HellPie'' is a "pink powder", a drug that is obviously meant to be a stand-in for cocaine.



* The ingredient you get for helping Lil' Smoke in ''VideoGame/HellPie'' is a "pink powder", a drug that is obviously meant to be a stand-in for cocaine.

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Since this is a medication rather than an "addictive or psychedelic substance" (per the description), I don't think it's this trope.


** Neuropozyne from ''VideoGame/DeusExHumanRevolution'' and ''VideoGame/DeusExMankindDivided'' is a drug that [[{{Cyborg}} augments]] take to prevent rejection syndrome.[[note]]''Not'' the same as organ transplant rejection. While people in RealLife have to take anti-rejection drugs when they have ''organic'' transplants that don't perfectly match their antibody profiles and are thus rejected by their immune systems, augments in the game take Neuropozyne when they have ''cybernetic'' transplants that leave "nerve scars" which eventually interfere with the integrity of the neuroprosthetic junction between body and machine.[[/note]] Neuropozyne is available as prescription only and its distribution is heavily monitored, which has lead to it selling for exorbitant prices on the secondhand market. In ''Mankind Divided'', with the augmented population reduced by the Incident and general [[FantasticRacism anti-aug sentiment]], the already-expensive drug has become even harder to come by, and shortages are an endemic problem among the remaining augmented.
** Also from ''Mankind Divided'', Neon is a recreational drug on the streets of Prague, which is inhaled and causes the user to vividly hallucinate rich colors. Apparently, it does not react well with neuropozyne though, and causes lethal seizures when the two drugs are combined in the same system.

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** Neuropozyne from ''VideoGame/DeusExHumanRevolution'' and ''VideoGame/DeusExMankindDivided'' is a drug that [[{{Cyborg}} augments]] take to prevent rejection syndrome.[[note]]''Not'' the same as organ transplant rejection. While people in RealLife have to take anti-rejection drugs when they have ''organic'' transplants that don't perfectly match their antibody profiles and are thus rejected by their immune systems, augments in the game take Neuropozyne when they have ''cybernetic'' transplants that leave "nerve scars" which eventually interfere with the integrity of the neuroprosthetic junction between body and machine.[[/note]] Neuropozyne is available as prescription only and its distribution is heavily monitored, which has lead to it selling for exorbitant prices on the secondhand market. In ''Mankind Divided'', with the augmented population reduced by the Incident and general [[FantasticRacism anti-aug sentiment]], the already-expensive drug has become even harder to come by, and shortages are an endemic problem among the remaining augmented.
** Also from ''Mankind Divided'',
''VideoGame/DeusExMankindDivided'', Neon is a recreational drug on the streets of Prague, which is inhaled and causes the user to vividly hallucinate rich colors. Apparently, it does not react well with neuropozyne though, and causes lethal seizures when the two drugs are combined in the same system.
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Since this is a medication rather than an "addictive or psychedelic substance" (per the description), I don't think it's this trope.
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* Subverted in the ''TabletopGame/MutantsAndMasterminds fan setting ''[[https://www.echoesofthemultiverse.com/viewtopic.php?t=1631 The World Less Magical/The World in the Aftermath]]'', in which thionite is an expensive form of cocaine treated with the setting's GreenRocks -- a procedure that does not actually alter its effects in any way.

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* Subverted in the ''TabletopGame/MutantsAndMasterminds ''TabletopGame/MutantsAndMasterminds'' fan setting ''[[https://www.echoesofthemultiverse.com/viewtopic.php?t=1631 The World Less Magical/The World in the Aftermath]]'', in which thionite is an expensive form of cocaine treated with the setting's GreenRocks -- a procedure that does not actually alter its effects in any way.
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* Subverted in the ''TabletopGame/MutantsAndMasterminds fan setting ''[[https://www.echoesofthemultiverse.com/viewtopic.php?t=1631 The World Less Magical/The World in the Aftermath]]'', in which thionite is an expensive form of cocaine treated with the setting's GreenRocks -- a procedure that does not actually alter its effects in any way.
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* ''Literature/TheForeverWatch'' has Psyn, which boosts psionic powers but also causes madness in long-term users. It's practically the only thing on the ''Noah'' that's actually illegal (while you can't get actual cocaine or heroin, you can purchase memories of what it feels like to use them).
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* Played with in ''Film/{{Transformers}}'' when a police detective accuses Sam of partaking in "mojo", which he assumes is a designer drug. "Mojo" is the name of the family's chihuahua, and the drugs are said dog's painkillers.

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* Played with in ''Film/{{Transformers}}'' ''FFilm/Transformers2007'' when a police detective accuses Sam of partaking in "mojo", which he assumes is a designer drug. "Mojo" is the name of the family's chihuahua, and the drugs are said dog's painkillers.

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