History Funny / TheBindingOfIsaac

* On November 4th 2022, in order to promote a special G-Fuel flavor based on he game, a special daily challenge was made which gives Isaac a G-Fuel Item at the start of each floor. What does it do? Well, it gives Isaac an increasingly absurd combination of Base game items and First Person Shooter weapons, including [[ShotgunsAreJustBetter Shotguns]], Machine Guns, and even ''rocket launchers''. No, not the Dr. Fetus + Rocket Jar synergy, an '''actual rocket launcher'''. Also, the more G-Fuels you get, the more often [[StuffBlowingUp everything explodes]]. Oh, and overtime, as you pick up more G-Fuels, the narrator's voice grows progressively louder, until it gets to the point when the narrator just yells, "[[LargeHam G-FUELLLLLLLLLL!]]" whenever you pick up a G-Fuel.

* On November 4th 2022, in order to promote a special G-Fuel flavor based on he game, a special daily challenge was made which gives Isaac a G-Fuel Item at the start of each floor. What does it do? Well, it gives Isaac an increasingly absurd combination of Base game items and First Person Shooter weapons, including [[ShotgunsAreJustBetter Shotguns]], Machine Guns, and even ''rocket launchers''. No, not the Dr. Fetus + Rocket Jar synergy, an '''actual rocket launcher'''. Also, the more G-Fuels you get, the more often [[StuffBlowingUp everything explodes]]. Oh, and overtime, as you pick up more cans of G-Fuel, the louder the narrator's voice becomes, until it gets to the point when the narrator just yells, "[[LargeHam G-FUELLLLLLLLLL!]]"
** What's better? The fact that a G Fuel Run can be played at any time using the seed: GFVE LLLL

* On November 4th 2022, in order to promote a special G-Fuel flavor based on he game, a special daily challenge was made which gives Isaac a G-Fuel Item at the start of each floor. What does it do? Well, it gives Isaac an increasingly absurd combination of Base game items and First Person Shooter weapons, including [[ShotgunsAreJustBetter Shotguns]], Machine Guns, and even ''rocket launchers''. No, not the Dr. Fetus + Rocket Jar synergy, an '''actual rocket launcher'''. Also, the more G-Fuels you get, the more often [[StuffBlowingUp everything explodes]].

* This, of all games, has one where in one of the endings, Isaac picks up a fetus in a jar...and is shown wearing a Dr. Fetus Costume.

* On November 4th 2022, a special daily challenge was made which gives Isaac a G-Fuel Item at the start of each floor. What does it do? Well, it gives Isaac an increasingly absurd combination of Base game items and First Person Shooter weapons, including [[ShotgunsAreJustBetter Shotguns]], Machine Guns, and even ROCKET LAUNCHERS, no not the Dr.Fetus + Rocket Jar synergy, AN ACTUAL ROCKET LAUNCHER! Also, the more G-Fuels you get, the more often [[StuffBlowingUp everything explodes]]!!! [[PunctuatedForEmphasis HAVE! FUN!]]

** Mars: "Double tap dash" turns Isaac into the boss War (based on the Biblical horseman). For some theological crossed wires, Mars is the god of war in Roman mythology.

* During the second phase of the Dogma battle, there are preachers in the background rambling and ranting verses of the Bible and the way they say their lines is such [[CarefulWithThatAx an over the top way]] that you can't help but laugh even in spite of Dogma being a KnightOfCerebus.

* During the second phase of the Dogma battle, there are preachers in the background rambling and ranting verses of the Bible and the way they say their lines is such [[BeCarefulWithThatAx an over the top way]] that you can't help but laugh even in spite of Dogma being a KnightOfCerebus.

** Uranus: "Ice Tears" turns Isaac into AnIcePerson and his tears can freeze enemies into statues for an instant kill on regular enemies if a threshold is passed. While it's mainly a reference to Uranus being extremely cold (with an average surface temperature of -353 degrees Fahrenheit) it also paves the way for a hilarious (if not [[ObligatoryJoke obvious]]) joke: [[UranusIsShowing Icy Uranus]].

** It's extra funny if one of your items is Ipecac or Number One. You literally [[SuperSpit spit]]/[[UrineTrouble pee]] on them to death!
* On another note, due to the way synergies work, your tears change shape, color, and size. [[BreathWeapon Brim]][[BloodyMurder stone]] results in a good-sized blood beam fired from the mouth, as an example... but you get Number One, it turns yellow. Yes, your character goes from firing blood lasers to firing ''pee lasers''. [[{{Squick}} From the mouth, too.]]

* During the second phase of the Dogma battle, there are preachers in the background rambling and ranting verses of the Bible and the way they say their lines is such a over the top way that you can't help but laugh even in spite of Dogma being a KnightOfCerebus.

* Any of the secret messages from the Fortune Telling machine. Some of these include cryptic nonsense like "[[Franchise/MortalKombat LOOK TO LA LUNA]]" or "[[Film/PeeWeesBigAdventure DON'T LEAVE THE HOUSE TODAY]]". Then there are some that seem to be talking to the player, such as "GO OUTSIDE" or "YOU ARE THROWING YOUR LIFE AWAY". The way the game is just totally fucking with you in this moment is priceless. Oh, the best of all these? YOU ARE WORSHIPPING A SUN GOD.

** Taken UpToEleven should Tainted Samson use Suplex during his BerserkerRage. He slams things into the ground so hard that they EXPLODE!

* Cancer, in real life, is a horrible, life-threatening disease. Cancer in ''The Binding of Isaac'' is probably one of the best trinkets in the game, since it ''doubles'' your tear-firing rate, even if you've already hit the cap. The tagline description for it in ''Rebirth'' is even ''"[[ARareSentence Yay, cancer]]!"''

* The icon for the 1000000% achievement? A glittering stop sign with a gold background. The message? "[[CompletionMockery Just Stop!]]"

* Sometimes, if you get particularly good items during a run (especially in the early floors), bosses go from mildly difficult to a complete joke. In fact, it's not uncommon for the following scenario to take place: the VersusCharacterSplash appears, showing the boss looking menacing compared to your crying character... and almost immediately after the fight begins, the boss reduced to a big red splat mark on the floor once you let'er rip. The AntiClimax potential can easily elicit a few chuckles. Especially if it's one of the harder endgame bosses, which crosses over into [[SugarWiki/MomentOfAwesome Awesome]].

* Tainted Jacob's gimmick is that [[StalkedByTheBell after a given amount of time passes, the wretched spirit of Esau will rise from Hell]] and begin relentlessly chasing Jacob, hellbent on killing him. It's a tense and difficult mechanic to play around, but you can also foil Esau ''permanently'' by... [[CessationOfExistence throwing an eraser at him.]] [[NotMakingThisUpDisclaimer Yes, you read that right.]] The vengeful soul of Jacob's brother can be easily vanquished... by an eraser to the face. And no, he doesn't even get DraggedOffToHell by Big Horn like he usually does — he just straight up vanishes.
* Tainted Jacob is based on the Biblical story of Jacob fleeing after taking Esau's birthright. So what happens when he gets the Birthright item? [[PoisonMushroom It summons]] ''[[PoisonMushroom another,]]'' [[PoisonMushroom shadowy Dark Esau]]; in other words, grabbing it just pissed Esau off even more.

* In the event that 700+ items isn't enough variety for the player, ''Repentance'' introduces "Glitch Items" that are found from TMTRAINER or have a chance to be in Secret and ERROR Rooms after beating Delirium with Tainted Eden. They can do ''anything,'' to the point of some downright absurd effects, [[https://old.reddit.com/r/bindingofisaac/comments/mj0xv9/the_binding_of_isaac_repentance_delete_this/ such as replacing fireplaces with End Chests and allowing the run to be ended in fifteen seconds.]] The DELETE THIS challenge has the player start the run with TMTRAINER and go all the way to ???, ensuing a chaotic run.

*** Not as funny when they're gold chests, as you end up wasting two or three keys, or might not even be able to open all of them.

* The fact that you can [[DealWithTheDevil sell your soul...]] [[SoldHisSoulForADoughnut for a quarter.]]

* Tainted Jacob is based on the Biblical story of Jacob fleeing after taking Esau's birthright. So what happens when he gets the Birthright item? It summons ''another,'' shadowy Dark Esau; in other words, grabbing it just pissed Esau off even more.

** Reversed Emperor sends you to a boss fight 2 floors after. If used in the ??? floor, it will spawn '''MONSTRO''' instead, and you get Hush's completition marks by beating Monstro.

* Several of the new planetarium items embody puns based on what they do in relation to what sign they represent. These range from the painfully obvious to the hilariously subtle.

** Uranus: "Ice Tears" turns Isaac into AnIcePerson and his tears can freeze enemies into statues for an instant kill on regular enemies if a threshold is passed. In other words: Icy Uranus.

** Terra: "Born to rock" turns Isaac into a RockMonster and his tears into high damage boulders that can break things. The pun is so obvious it is garunteed not to rock anyone's world view.
** Uranus: "Ice Tears" turns Isaac into AnIcePerson and his tears can freeze enemies into statues for an instant kill on regular enemies if a threshold is passed. In other words: Icy Uranus.

-->'''Birthright Description''': It's not yours.

* Tainted Jacob is based on the Biblical story of Jacob fleeing after taking Esau's birthright. So what happens when he gets the Birthright item? It summons ''another,'' shadowy Dark Esau, in other words grabbing it just pissed Esau off even more.

** Taking three Puberty pills gives the "adult" transformation, which is just a free health-up... but also gives Isaac some scraggly facial hair. This applies on ''all'' characters, including [[BeardedLady female ones]].
* Even more amusing pills in the remake. A new pill effect is "R U A Wizard?" This causes Isaac to get a derpy, wall eyed look that forces him to shoot his tears diagonally for a short while.

** ''Rebirth'' continues these messages with blatant insults like "YOU WERE BORN WRONG", or [[AscendedMeme "REBIRTH GOT CANCELED".]]

** As another rung to how goofy Sloth is, Edmund would later confirm that the Bob items and transformation are in fact referring to Sloth by his first name. In addition, this mean that Sloth finally gets a unique sprite set due to the Bob transformation... and then he can't be bothered to use it. And on the final rung of these recurring bits of lore, Edmund has also stated that Sloth represents the brother of Isaac's father... Meaning that logically, Bob's your uncle.

* The fact that you can [[DealWithTheDevil sell your soul...]] [[ComicallySmallBribe for a quarter.]]

* The icon for the 1000000% achievement? A glittering stop sign with a gold background. The message? "Just Stop!"

** Hornfel has always had a problem with getting motion sick when he goes too fast... so when Loki starts posing faster and faster to fire off larger volleys, [[VomitIndiscretionShot it ends predictably]]. The tell for this attack even has Hornfel [[ThisIsGonnaSuck realize exactly where this is going]] before Loki starts.

* The Reverse arcana Tarot Cards are an interesting lot, having effects that are either the opposite of the original card, or behave in the spirit of that opposite. Death Reversed turns two enemies in the room into charmed skeletons, Temperance Reversed causes Isaac to eat five random pills, etc. But Tower Reversed has among the most outlandish interpretations of this; instead of dropping several bombs into the room and destroying most rocks and pots in it, the card causes ''reverse explosions'' that will ''create'' rocks and pots in a way that leaves the exits unobstructed.

* The trailer for ''Repentance'' is basically Awesome all the way, but in one instance, as it flaunts the game having MORE ENEMIES, MORE ITEMS, MORE ROOMS, MORE ACHIEVEMENTS, it suddenly drops ''MORE POOP''!

* Tainted Jacob is based on the Biblical story of Jacob fleeing after taking Esau's birthright. So what happens when he gets the Birthright item? It summons ''another,'' shadowy Dark Esau, in other words grabbing it just pissed Esau off even more.

* Tainted Jacob's gimmick is that [[StalkedByTheBell after a given amount of time passes, the wretched spirit of Esau will rise from Hell]] and begin relentlessly chasing Jacob, hellbent on killing him. It's a tense and difficult mechanic to play around, but you can also foil Esau ''permanently'' by... [[CessationOfExistence throwing an eraser at him.]] [[NotMakingThisUpDisclaimer Yes, you read that right.]] The vengeful soul of Jacob's brother can be easily vanquished... by an eraser to the face. And no, he doesn't even get DraggedOffToHell by Big Horn like he usually does — he just straight up vanishes.

** Even funnier is the Horse Pill version of "I Found Pills": When Isaac takes it, he gets a face that seems to look like he's doing an exaggerated impression of a horse, because ''[[JustForPun horse]]'' pill (this is the current page image). If the face wasn't funny enough, the voice clip for this pill has the narrator shouting in a [[LargeHam hammy]] voice, "I FOUND PILLS!"

** Even funnier is the Horse Pill version of "I Found Pills": When Isaac takes it, he gets a face that seems to look like he's doing an exaggerated impression of a horse (because ''[[JustForPun horse]]'' pill). If the face wasn't funny enough, the voice clip for this pill has the narrator shouting in a [[LargeHam hammy]] voice, "I FOUND PILLS!"

* An addition made in ''Repentance'' is Horse Pills; Larger pills that grant exaggerated versions of the typical effects; Good becomes great, bad becomes worse, and [[LargeHam the narrator is more hammy]]. This is applied to almost every pill in the game... including the already funny "I Found Pills", which causes Isaac's face to morph into a horse's grin while the narrator screams "I FOUND '''PILLS!'''" at the top of his lungs.