Angie is seen wearing a pro-vegetarian shirt in one episode. Her actress, Constance Marie, is a devout vegetarian in real life.
"Angie Gets Tanked" has George make fun of an overweight boy named Lawrence Baxter by shouting "Hercules! Hercules! Hercules!". Lawrence is played by Jamal Mixon, the same boy who played Ernie Klump, Jr. in The Nutty Professor.
Cuban Angie is played by Mexican Constance Marie (whose real last name is, ironically, Lopez)
Carmen's actress Masiela Lusha is actually Albanian-American.
Manny Lopez, a Mexican, is played by Cuban actor William Marquez.
Keep Circulating the Tapes: Seasons 1-6 have been released on DVD, with the second half of the coming from the Warner Archive Collection. The only issue with the first three is that they're in 4:3, even though the show was made in 16:9.
Mean Character, Nice Actor: Benny's actress Belita Moreno. During an interview with George about the show he was asked which actor is the least like their character, He said that unlike Benny, Belita is a very nice person.
The Other Darrin: Mrs. Cardenas, in her first appearance, is played by actress Lilian Hurst. Afterwards she is played by a different actress, likely in a fat suit to make her appear morbidly obese and voiced by a man.
Producers: Sandra Bullock is a co-executive producer of the show; she's good friends with Lopez and helped get his show off the ground, then eventually had a guest-starring turn as Accident Amy.
Real Life Writes the Plot: Max was written having kidney disease due to the real George Lopez's own experience with it. Also, the episodes about George stealing George W. Bush's speech were inspired by the Real Life George Lopez stealing one of the then-president's speeches. Thankfully, he confessed before he could face serious repercussions.