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Danny boy, a lazy worker voiced by Lopez, always called into work with hilarious phone calls, making excuses for not being there. This eventually stops, and seems like Chuck Cunningham Syndrome, but considering he never showed up, he was actually probably fired.
In one episode Benny says she drinks to the point where the man she's interested in looks like Tom Selleck. She drunkenly makes out with Angie's dad in one episode, and he kinda resembles him, as well as other men she's dated on the show.
When Max has his birthday party, George says he never had one and ends up meeting H.R. Pufnstuf, one of his favorite shows as a child. Since George had a crappy childhood, it makes sense he'd like a show where a child lives in a fantasy world.
In the pilot episode George makes jokes that Carmen's adopted. While this his way to tell her to be truthful, it has some Reality Subtext since Carmen's actress is the only main cast member who's not Hispanic. (She's Albanian)
In the episode "George Helps Ernie See The Cellulight"" Ernie becomes too fat to do his job, and George realizes his overeating is due to anxiety about dating after he got his own place. There are a couple events that could've triggered it. In the episode where he moves out, he's waving to a girl outside and George calls him a creepy guy upstairs. In the Christmas episode that same season, George and Angie become marriage counselors at church and Ernie asks for help with dating. George says it'd take a miracle to help him. Ernie's sensitive as it is, so George's comments were more than likely nails in the coffin.
Discussed in "George Helps Ernie See The Cellu-Light." If Ernie didn't lose weight, he could end up as big as his mom. She's morbidly obese, and we never see her on screen. Her size is Fridge Horror in itself.