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WMG: The George Lopez Show

Benny has a long-lost twin sister
Namely, Grandma Magdalena from Wizards of Waverly Place. They're both portrayed by Belita Moreno, and they both have a grandson named Max. This, of course, means that George and Theresa are cousins, and the Russo kids are distant cousins of the Lopez kids. No wizardry in George's family, though, since it's the mortal side of the family.
  • In an interesting twist, Theresa and Veronica's mom are both portrayed by Maria Canals Barrera. So...the Russo kid's are related to George AND part of Angie's family.

MacLeod was immortal.
Beni gave him that name because he seemed to survive anything that was thrown at him (from pickup trucks to seemingly lethal volumes of alcohol), but didn't really believe that he was A) immortal and B) outside the burning building. While B could have been true, the guess assumes that it was not, thus requiring A to be the case.

Benny is an older Haruhi Suzumiya.
George's misery is all because she wished for it. Angie would be the Kyon, George the Mikuru, and Ernie the Itsuki.

Ernie is gay
He's in his late 30s/early 40s, has trouble with women, is sensitive, and there was the What If Episode where he and George are a gay couple. George realizes he likes Angie and it makes Ernie cry. In the second to last episode when George imagines Max working at the plant, he tells Ernie he'll marry a rich male swimsuit model, to which Ernie replies "How rich?"
  • Jossed. Ernie's shown a very clear and legitimate interest in women, especially Angie. Furthermore, George was the one having the dream, not Ernie. He was lucid dreaming. Ernie's actually the Bill Dauterive of this show's universe, except the writers actually cut him some slack.