California Doubling: The scenes happening in Bolivia were actually filmed in Panama, Chile and Peru.
Creator Backlash: Daniel Craig wasn't fond of how production went (Reports suggest he and the director were making it up as they went along), saying that thanks to Quantum of Solace, he'd never do a film without a script nailed down again. Fortunately, it didn't turn him off doing another Bond film, as it was followed by the far better received Skyfall.
Troubled Production: The film was stalled in pre-production by the 2007 Writers' Strike. Based on various accounts, screenwriter Paul Haggis was frantically finishing a first draft hours before the strike deadline and/or Daniel Craig and director Marc Forster rewrote script pages themselves during production. In addition, the fragmented nature of the production (due to the strike) led to a rushed and nearly-incoherent plot.
The film wasn't originally a direct sequel to Casino Royale (2006), but seeing as the 2007 Writer's Strike left them with the minimum of a script it was given stronger connections to the preceding movie.
Al Pacino was reportedly considered for General Medrano.