- Blooper:
- Near the end of "The Globfather" as one of Sal Monella’s henchman grabs for Ozzy, his arms and suit turn the same colors as Sal.
- In "A Cold Day in Hector" as Spyrman chews out Ozzy, the score box for Spyrman's snowboarding video game briefly moves the 1 decimal going into the 2100 range below the box and enlarges it.
- Celebrity Voice Actor: The lack of Chris Rock and David Hyde Pierce aside, the show featured a handful of well-known guest stars, such as Tim Curry, Justine Bateman, Vivica A. Fox, Jeffrey Tambor, Brad Garrett, Henry Winkler, Brian Posehn and Jim Belushi.
- Crossdressing Voices: Alanna Ubach voices Mayor Spryman.
- The Other Darrin:
- Naturally. Chris Rock is replaced by Phil LaMarr as Ozzy, and Jeff Bennett takes over David Hyde Pierce's role as Drix.
- Ernst Strepfinger is voiced by Brad Garrett in season 1, and by Jim Cummings in season 2.
- Recycled: The Series: Clips from the movie are reused, including the runny nose scene, Frank yawning, and Drix dancing in the title sequence.
- Recycled Script: "Street Up" is essentially Ozzy and Drix’s take on the SpongeBob SquarePants episode "Walking Small".
- What Could Have Been: Early concept art for the series shows that Maria Amino was originally going to be orange and a head taller than Ozzy, and Mayor Spryman was going to be pink.
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