Explanation for Frank going back to being a slob in the first episode...
- It's an Alternate Universe in which Shane was never born. Simply.
- Or it happened after Ozzy's award ceremony and before his hike with Shane.
- Shane died in an accident during the hike and Frank reverted back to his old habits as a coping mechanism.
Ozzy and Drix would have eventually returned to Frank.And Maria, Dander, and Backseat would have come with them.