WMG: Ozzy and Drix

Explanation for Frank going back to being a slob in the first episode...
  • It's an Alternate Universe in which Shane was never born. Simply.
  • Or it happened after Ozzy's award ceremony and before his hike with Shane.

Ozzy and Drix would have eventually returned to Frank.
And Maria, Dander, and Backseat would have come with them.