Franchise Killer: Though there was another one after it, The Final Destination was the film that brought the series past the point of no return. It was the biggest hit in the franchise since the first, largely thanks to the addition of 3D, but it was so poorly received by critics and fans alike that people stayed away in droves from Final Destination 5, leading to that film's failure driving the final nails into the coffin (despite generally being considered a much better movie).
Too Soon: The 9/11 reference in Final Destination 3 (a picture of one of the towers covered by a shadow of a plane), which was considered tasteless and offensive by critics, is removed from the TV version of the film.
What Could Have Been: In the early stages of Final Destination 2, Tim Carpenter was envisioned as a 5-7 year old, but there was uneasiness in making a movie where such a young character gets killed in a gruesome fashion. In the movie proper, he was born 1986 and met his end on May 14, 2001, still making him the youngest victim in the series.
James Wong of the The X-Files wrote a script for the show that was never used. This script was adapted into what would become the first Final Destination movie.
The working title for the first film was "Flight 180", but was changed due to Executive Meddling on the grounds that it was too similar to other plane-related films like Con Air and Air Force One.
Alex was going to be in the 2nd movie, but negotiations fell through with actor Devon Sawa, so he was killed off.
Word of God: It is stated in Final Destination 3 that Kimberly and Thomas, the only survivors of Final Destination 2, died five years ago, just before the last three people of Final Destination 3, thus sealing the really complicated rift created by their survival.