This is based on opinion. Please don't list it on a work's trope example list.
Tear Jerker / Final Destination
The end of Final Destination 5. Though like most of the endings it was something to be expected, since you can't escape death. We have the two survivors that cheated death, now they move on. After hearing the freak out from the first movie, the happy mood changes to Oh, Crap!. The plane sucks Molly out of the window seat as Sam desperately tries to hold on. She slips and dies getting sliced in half by the wing. Rather than panic Sam simply has a Heroic B.S.O.D. for a few seconds and then closes his eyes in acceptance before the fire burns him to death. Of course this turned into a Crowning Moment of Funny when the landing wheel just so happens to hit the last survivor... moments after he found out the man that he killed was gonna die in a few days anyway.
Final Destination 2 manages to make you feel sorry for almost everyone on Death's list. Some examples:
When Nora tells Kimberly she has accepted that she's going to die because there's nothing left for her after her husband and her son's deaths.
Makes it worse when she's getting her head cut off by the elevator, she starts screaming "I don't wanna die!".
Seeing Nora witnessing her son's horrible death and sobbing uncontrollably.
As Kat is stuck in her car, Clear goes to check if she's all right. Despite having been selfish and uncaring before, Kat tells her to search for Isabella, as she will be fine. It's the first time she shows empathy towards the rest of the group.
In Final Destination 3, you can't help feeling sorry for Wendy when she realizes that her boyfriend Jason is still in the roller coaster. She was very desperate to get him off that ride since she was the one that had the premonition of the coaster crashing.
In Final Destination, when Tod is telling the FBI agents that his brother told him to keep an eye on Alex and that he stayed on the plane. The look on Tod's face when he realizes his brother died.
Mr and Mrs. Waggner, losing both their only sons, George and Tod, in the span of one month. Not only do they have to deal with losing George on Flight 180, but they're also left believing Tod "committed suicide" out of guilt for having George stay on the plane.
In the film, learning Clear Rivers's backstory. You can't help but feel sympathy for a seventeen-year-old girl whose father was shot and who was neglected and eventually completely abandoned by her mother.
Clear Rivers's death was also rather sad in the sense that, out of every character in each Final Destination film, she was the one who managed to outsmart death, even if it meant she wasn't necessarily 'alive.' She leaves the safety of a padded cell to help victims experiencing a similar fate. In the long run, helping is what kills her.
Regardless of the quality of said franchise, the idea that several people are being hunted down by Death itself simply for trying to "cheat" death. Seeing as how powerful Death is, you'd think it would just give them quick, painless deaths, but instead goes out of its way to induce pants pissing amounts of fear and paranoia, only for the victims to die cruel and unusual deaths (though not all of them are unusual, the methods still seem cruel). The entire premise of Final Destination seems at least somewhat Tear Jerker ish given that Death is going on what basically consists of a Roaring Rampage of Revenge just because some people want to do what many people want to do; LIVE.
Whether they realize it or not, these characters are practically forced to accept death at this point in their lives, because their attempts to outrun Death are ultimately futile and will always be in vain.
Just the fact that the majority of Death's victims throughout the series are teenagers and young adults cut down in their prime and the psychological, emotional devastation that does on their parents, relatives and friends.
On a meta level, it's a bit of a bummer how these films have contaminated the mellow, folksy mood of John Denver's music for so many people, who now associate his songs with Rube Goldberg-esque deaths rather than the beauty and pleasures of the open countryside.