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Tear Jerker: Grand Theft Auto V
In Johnny Klebitz's cameo, we are treated to seeing Trevor stomping his head in, and when he leaves, Ashley just collapses at Johnny's body crying.
The Lost in general, really. In just half a decade, they've degenerated into a small enclave of dirt-poor, rapidly-aged desert methheads. Trevor pounds the final nail in their coffin. It was sort of inevitable with the way The Lost and Damned ended.
Gets even worst when you listen to the dialogue of the surviving members of the Lost during the wake. They all blame Johnny for the state their gang is in, and believe that Billy would've been a better leader, refusing to believe the "rumors" that Billy was planning on selling the gang out.
In hindsight seeing Grove Street now being run by Ballas, complete with a run down version of the Johnson house.
Especially if you kill Michael, after he got his life around.
Oh, it's even worse. From Michael's distraught voice as he screams how Franklin was like a son to him, and that Michael practically let him stay at his house, to the shot of Michael's corpse on the ground and Franklin looking like he's just fighting back tears when he sees what he's done. It hits home that they really did look to each other. The conversation that Michael and Franklin have before Franklin tells Michael that he's going to kill him worsens it all the more.
As if that wasn't enough, you can be contacted by both Jimmy and Amanda, both distraught at Michael's death and angry at Franklin for killing Michael.
Michael: "You hypocrite! I shoulda clipped you when you broke into my house!......I'm all you've got! You made the wrong call!"
Trevor really suffers from abandonment issues, if "Mrs. Philips" is any indicator. Trevor's mother returns and she asks him to get her a literal van full of Deludamol, presumably a pain killer of some sort. He does it without question, but when he returns to the trailer he finds it empty. He searches each room frantically, calling out to her as he does, but when he realizes she isn't there, he drops to the floor screaming, holding his hands to his head. It's a heartbreaking moment for him if there ever was one.
After the scene in question, control will automatically switch over to one of the other two characters- switch back to Trevor quickly enough and he can be seen sobbing for his mother on the couch in his trailer, taking something that may well be some of the Deludamol you just dropped off. While possibly not directly related, if you choose to huff gas immediately afterward, Trevor will pass out and wake up in an empty pool, and say the following, with obvious dejection in his voice-
Trevor: "Man, that stuff is pointless, all it does is make me realize how awful everything about existence really is..."
It's scenes like this, and smaller ones through the game (like his sincere concern over Michael's daughter), that make it clear that Trevor is a deeply fucked-up individual, even if he has gone beyond the line of any sympathy.
What about the hint that his mother was a hallucination? That's just heartache incarnate.
Earlier in the game he starts blubbering when he has to let Patricia Madrazo return to her husband, and, boy, was he clearly torn up about it.
Perhaps the saddest part of that scene was when Trevor pitifully asks "Why does everyone I love abandon me?" Who would have thought that you could feel so sad for such a violent lunatic?
Which makes it more understandable, though no less horrible, when the very next time he meets Floyd, the encounter ends with a brutal murder. Floyd (and to a greater extent, Floyd's girlfriend Debra) was kicking him out, and he just couldn't take another perceived betrayal.
Franklin's friend, and possible Old Flame, Tonya. She's a drug addict in an emotionally abusive relationship with a lazy bum who refuses to go to work. While she's no catch herself and guilts Franklin into doing her boyfriends work for him, she's actually still out there making sure he keeps his job while it's implied that he is cheating on her. Throughout the side missions, it also becomes more and more apparent that she's become victim to her own addictions as well.