Eggman's Egg Grapes. Sounds like a goofy name right? Actually they're devices that suck the life from living beings and turn it into energy for Eggman to use. He ends up killing almost all of Albion's inhabitants using them.
In issue #60, the Iron Queen vowed to return after her defeat. When she finally did, she took over New Mobotropolis and Nicole.
Mina didn't take the Iron Dominion's invasion of New Mobotropolis well. Particularly Nicole being Brainwashed and Crazy.
"If you or any of your echidna-buddies cross me, you're all going up like a fireworks festival." Complete with a Slasher Smile and the green lighting, Eggman just proved he can still scare if he wants to.
Issue 256: Thanks to Eggman disrupting Sonic's Chaos Control at the end of the crossover, the entire multiverse collapsed on itself, with Mobius Prime and Blaze's world being the only confirmed survivors. Eggman has committed the single greatest act of mass-murder in the comic's history. And then Mobius breaks apart.
Sonic gets a face full of the dark energy that's seeping out of Mobius's core and, with every stressed-out moment from then on, comes dangerously close to snapping. This version of the Werehog may not be as benign as his game self.