Palutena: How can you tell?
- Robots in Masamune Shirow's work (Ghost in the Shell, Appleseed) often do something very similar: speaking in bar codes!
- The old modem like chirping emitted by droids in Star Wars films is called "binary" in-universe. However, it's unknown whether it's binary as we know it and how is it encoded into sound.
- Ashley, and all the other aliens, in Jasper Fforde's Nursery Crime series have binary as their native language. They also play binary Scrabble.
- Appropriately, Binary Larry in Emily The Strange Stranger And Stranger. He writes a message on the sewer walls in binary. Emily knows how to decode it.
- Binary Larry has a friend named Hex Lex who chisels code into the sidewalks in hexadecimal (base 16).
- In Star Trek: The Next Generation, there is a race called the Bynars, which speak to each other in binary.
- Previously, in The Original Series once the Enterprise tried to contact the probe Nomad it replied in a binary code. Then it sends mathematical message requesting language equivalence, leading it to speak in English afterwards (which does not fit Aliens Speaking English since Nomad was made in Earth).
- Joe from NewsRadio claims to be able to read binary.
- In Red Dwarf, Kryten uses binary as droidspeak on occasion. In "Terrorform" he gives a very long set of binary as an "old droid saying" about not standing and blathering when you're in mortal peril
- In the Flight of the Conchords song "The Humans Are Dead", there is a binary solo.
- In Mass Effect 1, the final message from the rogue AI on the Luna Base is in binary. It translates into "HELP".
- When Pyrrhon from Kid Icarus: Uprising tries to control the Aurum, only for them to take control of him, he speaks out loud in binary; it translates to "KILL".
- Volt in Tales of Phantasianote speaks almost entirely in binary, causing a misunderstanding between him and the heroes which leads to a fight, and later, a contract.
- Pirate_Tinman speaks in binary because his actual voice is broken, as shown when he first booted up in Shadow of Israphel and also in "Sunshine of Israpony". This is used to call Lewis Brindley and Simon Lane idiots behind their back at some points.
- SF Debris makes this joke in this review of Star Trek: Voyager episode "The Killing Game". A Borg "love song" sung by Chuck!Seven is in binary with a hexadecimal verse.
- In Futurama, Bender says a prayer in binary. He ends with "2".
- There's also the Time Code from Bender's Big Score, a long list of zeros and ones that is said like an incantation to send the speaker back in time.
- In "Godfellas", the galaxy that may or may not be God signals Bender in binary. Bender mentions that he only knows enough binary to ask where the bathroom is (which contradicts the above, but hey, Rule of Funny).
- In an episode of ReBoot where the Plucky Comic Relief told a joke in binary; the "binary joke" comes out to "Take my wife, please!" when translated into ASCII.