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Anime and Manga
- Kenpachi and Yachiru from Bleach, though Kenpachi never seems to be actively trying to protect her. Especially since it's been hinted that she doesn't need the protection (to be more specific, she's the 11th division's assistant captain. Considering how division members are ranked, that means Kenpachi is the only one more powerful than her).
- On Code Geass, Charles Di Britannia and his "older" twin brother V.V. are a Jupiter and Mercury pair, with Charles being over 7 feet tall and V.V. having the appearance of a prepubescent boy since he physically stopped aging when he gained immortality.
- Ilya and Berserker from Fate/stay night.
- Mei the goat and Gabu the wolf from Arashi No Yoru Ni.
- In Neon Genesis Evangelion, Supposedly a pilot and his or her Evangelion unit.
- In Ouran High School Host Club, this is basically the appeal of Honey and his tall, dark and silent bodyguard, Mori. It's lampshaded a lot.
- Guy Gardner and Kyle Rayner fit this. Guy is the larger, older, more experienced and more physically powerful of the two, and while Kyle doesn't exactly need protection, not even God can help you if you hurt Kyle in front of Guy. Kyle is also one of the few people who can bring out Guy's well hidden tender side.
Film — Animated
- George and Lennie in Of Mice and Men, another inversion where the little guy is the one guiding the bigger guy. At least until the end.
- In the Sword of Truth, Chase is this to Richard while Richard is growing up. Richard and Gratch both have this role with each other at one point or another. Richard to Warren.
- In Codex Alera, Max is this to Tavi when they're academs. Subverted in that Tavi saves Max just as much as Max saves Tavi.
- In The Dresden Files, the Gruffs are a chain of this. (They're based on the Bill Goats Gruff from fairy tales. Since they're Fae, the stories are somewhat accurate.) Some of them are the size of bulldozers. Partial subversion since the Eldest Gruff is five feet tall, and one of the strongest Summer warriors, ranking him in the top few-hundred deadliest creatures in existence.
- Freak the Mighty features the viewpoint character taking the little kid under his wing.
- Gilligan's Island: The Skipper, a Boisterous Bruiser sailor, and Gilligan, his skinny first mate, are Heterosexual Life-Partners. The Skipper even occasionally refers to himself as Gillgan's "big buddy."
- Sam the Cute Bruiser protecting Carly the girly girl on iCarly.
- This is hinted at for Jayne and Kaylee in the pilot episode of Firefly, but never really shows up again.
- Hornswoggle was originally used as a weapon by Dave Finlay, but he didn't take too kindly to Michael Cole calling him a "little bastard". A face turn later and this became the two's relationship, with Vince McMahon instructing Finlay to look after Hornswoggle, whom he mistaken believed to be his bastard son.
- Baldur's Gate 2 has Minsc, a cheerfully loud tough guy, and his pet "miniature giant space hamster", Boo. Baldur's Gate also had Minsc protecting Dynaheir, his "witch", as part of a rite of passage. Though she doesn't appear in the second game, a dialogue can occur between him and another female caster, where he decides that now she's his witch. In either case, if his ward were killed in the game, he'd go berserk.
- Subverted in BioWare's Knights of the Old Republic. Mission is a Twi'lek teenager (using the smallest adult female model) and Zaalbar is a Wookiee - two meters and change of walking carpet (and probably about 80 to 100 years old, given Wookiee lifespans). While the big fellow does back Mission up in a fight, his language barrier and painful shyness means that Mission does most of the talking. She is also the street-smart one, though both of them are naive to varying degrees.
- Inverted (kind of) with Tae and Bollikin of Lusternia: the former a massive, hulking (but endearingly simple-minded) God, the latter a tiny and extremely intelligent (but also incredibly compassionate) God. They compliment each other perfectly, and are implied to be lovers.
- Starting from the second Darkstalkers game, we get two: Donovan the vampire hunter, who is accompained by Emotionless Girl Anita, trying to make her emotions return, and Huitzil, the huge Aztec robot who takes care of a young boy named Cecil, thinking Cecil is his new master.
- Seems to be the intended dynamic for Big the Cat and Froggy, their theme song even referring to a "big guy" and "little guy."
- The page illustration is a still of Marc Antony and Pussyfoot, who were the former Trope Namer. They starred together in a series of five Warner Bros. cartoon shorts, the most famous of which was the first, "Feed the Kitty".
- Chester and Spike/Alfie from "Tree for Two" and "Dr. Jerkyl's Hide".
- Pipsqueak and The Duke in Avatar: The Last Airbender.
- Rita and Runt have a similar big dog/little cat relationship, although in this case the little one is sophisticated and the big one is dumb (mistaking the cat for another dog).
- Dog Buttons and baby Mindy are the Badly Battered Babysitter version.
- Brought Up to Eleven and used to achieve Crowning Moment of Funny in the South Park episode with Cartman and Cthulhu. It even directly homages scenes from "Feed the Kitty".
- Yakky Doodle and Chopper (a duckling and a bulldog, respectively) on The Yogi Bear Show.
- With the same dynamic as the Yogi Bear Show example, there's Lambsy and Bristol Hound in It's the Wolf.
- Inverted by The Great Grape Ape and Beegle Beagle: Gentle Giant Grape Ape tends to be more childlike than his smaller canine partner.