- One of the Sigma Tau Delta Alpha Bitches in Hazed is majoring in "Hitler Studies". Main character Ileana's major is Women's Studies, which wouldn't be so unusual if she weren't a Sigma Tau herself.
- In Mr. Holland's Opus, it becomes a minor plot point that that the school's physical education teacher "minored in modern dance."
- James Bond himself, in the film version of You Only Live Twice, claims to have earned a first in Oriental languages from Cambridge. However, he only says this to Moneypenny and never demonstrates any great language skills, so it's possibly an exaggeration or joke.
- The James Bond books actually do emphasize Bond's language skills quite a lot.
- In Up in the Air, George Clooney's character inspires a recently fired man by reminding him that he had minored in French Cuisine.
- Adam frequently makes jokes to this extent about Jamie in MythBusters. While it's true Jamie has done some peculiar things — like being a licensed SCUBA instructor — most of them are made up by Adam on the spot for the lulz. Most of them gags on Jamie's age, such as offhanded mentions of his supposed actions during the Great Depression, though it is a fact that Jamie has a major in Russian Literature of all things.
- A Running Gag on Greek is that Cappie has supposedly majored in pretty much anything plot-relevant.
- A stripper in Bones mentioned majoring in Criminology while giving Booth a lapdance. In another episode, Sully mentions having minored in kinesics - he knew what a scapula was.
- The Have I Got News for You perennial gag of Paul Merton's CSE in metalwork.
- Annie Cartwright, quiet and put-upon mild-mannered WPC of Life On Mars, turns out to be a psychology graduate.
- Used as a joke in an episode of Full House. Normally straight-laced uptight Danny reveals that he's an ace at billiards since he played it all through college. Another character challenges him to darts and, when Danny scores two bullseyes in a row, Danny says, "I minored in Darts."
- Mad Men: Betty majored in Anthropology.
- Star Trek: Deep Space Nine: Bashir took extension courses in engineering at Starfleet Academy. O'Brien is actually grudgingly impressed by his abilities. Subverted in that it's later revealed that it was a changeling saboteur rather than Bashir who had carried out the work.
O'Brien: Not bad for an extension course.
- In The Sifl and Olly Show, Sifl reveals that he only has, "8 doctorates, one is just a masters in theoretical biomechanical interplanetary advancement".
- Fighter from 8-Bit Theater minored in an ancient, almost unreadable language, making him a Genius Ditz. Even though he never went to college.
- Kari of Crimson Dark took "Applied Riftspace Dynamics" in flight school. Not very useful for a fighter pilot.
Kari: I had a crush on the tute leader. [beat]. Hey, don't give me that look. I was seventeen, give me a break.
- The Real Man who plays Qui-Gon, and now Amidala, in Darths & Droids is doing a Ph.D. in geophysics. It turns out he is a serious academic in Real Life, but it counts for this because the focus of the story is on the events of the game, and he likes to shut his brain off in those.
- Captain Bob Smith of Legostar Galactica took a "Complex Linguistics" course at the "Academy"... which explains why he can talk to the engineer's cat (he also claims he can speak Wookiee and "a few other weird languages").
- Roy from The Order of the Stick took goat herding instead of horse riding as his compulsory animal husbandry class in fighter college, because it sounded like a easy A.
- He also studied engineering and architecture.
- And Belkar is a gourmet cook.
- In Questionable Content, Faye studied Art at college, and Raven has started studying Physics.
- Trigger Star has Sauerkraut, who has a masters degree in Liberal Arts and Finance, and paid for her education by using her football player physique to crush various monsters and people for money. Easier than getting a student loan, anyways.
- In Mission Hill, Andy mentions that he minored in massage at his alma mater, the notorious (fictional) party school Borthchmore, who's main claim to fame is its high number of fraternity drinking deaths.
- In one episode, Bender mentions that he went to Bending College, majoring in Bending and minoring in Robo-American Studies.
- In another episode, we even got a flashback to him getting this "major": as you would expect, it consisted of a data upload to his head. And then getting a diploma via robotic arm.
- In the first "Anthology of Interest" episode, Zoidberg says that he took correspondence courses in Murderology and Murderonomy.
- Jim "I'd Rather Not Talk About It" Moralès of Code Lyoko seems to have an Expansion Pack Past composed entirely of these, in Noodle Incident format.
- Kim Possible: Dark Action Girl and supervillain's sidekick Shego majored in Child Development, which is plot-relevant when it's introduced but still unexpected.
- The Veggie Tales spoof of Star Trek had this conversation:
Junior: But why ask me for help?
Bob: Didn't you minor in aerospace technology at the Happy Tots Preschool?
Junior: Why, yes I did!
Larry: What did you major in?
Larry: Me too!
- An early pre-Flanderization episode of The Simpsons has Flanders joke that he had a PhD in "Mixology" and make Homer a cocktail that gets him immediately hammered.
- Ratso, one of the lower leveled intellects in Jackie Chan Adventures, says he studied Theoretical Physics before becoming a crook.
- An early episode of Family Guy reveals that Dr Dre does indeed have an actual PHD, but when Chris asks him if he can fix himself up if he gets shot in a rap feud, Dr says that his degree is in optometry.
- Robert Mugabe, President of Zimbabwe, claims to have a degree in violence.
- Indiana University offers a "Build Your Own Major" major. It's the same way New York Times Crossword Puzzle Editor Will Shortz got his degree in Enigmatology.
- Uwe Boll holds a doctorate in Literature.
- Thanks to Polish psychologist Andrzej Łobaczewski, students may now receive an actual degree in evil—ponerology, in his terms. It's the study of societal causes of sociopathy and social injustice, although nonetheless his students can legitimately claim to have least taken a few courses in evil.
- Indie actress and screenwriter Brit Marling majored in Economics at Georgetown University and was offered a job with Goldman Sachs, then turned it down to pursue acting.
- In real life, most degrees completed do not have any minors at all, only one central major that is focused on.