When large lips are used in a humorous manner and/or used to mock European civilisation's obsession with plump pouters.
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- Naruto and company suspect that Kakashi might have this; their Imagine Spot gives us the page image.
- Hildagaard Rail in the story Sky Highway from the original Teenage Mutant Ninja Turtles comic book series, #30. She was a mutated German woman who had lips so big they took up most of the space on her face, going practically from ear to ear and forehead to chin. Otherwise she was very well endowed, had long legs and an hourglass figure. When Raphael attempted to leave Hilda she grabbed him by the tales of his bandana and gave him a giant kiss goodbye against his wishes. The lipstick mark she left on his face covered his entire beak.
- Gremlins 2: The New Batch: The female gremlin has ridiculously large lips.
- In The First Wives Club, Goldie Hawn's character gets an overdone collagen injection.
- Back when Africans were Acceptable Targets, this was a fairly common sight in children's cartoons.
- Gaia Online has a ghost of a supermodel equipped with the wax lips items, suggesting she's hit the collagen a bit too hard.
- In one Zits strip, Jeremy's lips swell up after he is stung by a bee while riding his bike. Cue the girls cursing how lucky he is and wondering whether they should take up beekeeping.
- Just Shoot Me!: Nina is invited to a talk show to talk about lipstick, but before she goes on, her peanut allergies act up after she eats some candy at the green room, giving her puffed-up lips and Elmuh Fudd Syndwome.
- Salvador Dali's Mae West Lips Sofa.
- This occurs more often in a depiction of a Gonk.
- Lena Hyena from Who Framed Roger Rabbit?
- There is a Russian series called "Odna za Vseh", meaning roughly "one woman who does everyone's job". Each episode consists of a string of short sketches, where the same actress plays a dozen vastly different roles. One of these is that of a millionaire's wife. Both she and her best friend have lips that look like they should be able to deflate them for storage.
- Jynx and Smoochum from Pokémon qualify. Some of their powers are centered on their lips, such as their attacks that involve kissing, and the Pokédex describes Smoochum as exploring the world using their sensitive lips.
- The Rolling Stones' logo (complete with gag tongue).
- On Hercules, Pain and Panic are sent to stop Icarus from kissing Cassandra (because that would violate her deal with Hades). One thing they try is to give him ridiculously large lips in an attempt to embarrass him out of kissing her. Instead, it just primes him up all the more.
- On SpongeBob SquarePants, Sandy has to battle her way through Karate Island in order to save SpongeBob. One of the minibosses she has to fight uses her lips as weapons. Sandy defeats her by drying her lips with a hair dryer until they are cracked.
- Gorgeous Gal in the Woody Woodpecker cartoon A Fine Feathered Frenzy. Since she is a bird there is a lipstick outline around her beak that can be viewed during a close-up. When she puckers up her lips are like a human's lips for comedic effect. At one point Gorgeous Gal appears in a bath and playfully blows bubbles at Woody and her lips are about the size of his face. Another time she rushes to kiss him with the full force of her lips and misses, kissing the wall. The lipstick mark she leaves on the wall is almost the size of Woody's entire body. Soon after that she spots him while she is on a couch wearing a red low cut red dress, says "Hi baby," closes her eyes and gives him a giant sized duck face inviting him to kiss her. Woody doesn't smooch her enormous puckered lips and runs. Whenever Gorgeous Gal does manage to kiss Woody her lips are shown to be much bigger than the Woodpecker's as well.
- In the Captain N: The Game Master episode entitled I Wish I Was a Wombatman a beautiful director's assistant who looked like a short pink octopus version of Dolly Parton had the hots for Simon Belmont. When she hugged him with four tentacles around his neck and arms she gave him a wink and extended her giant red lips in front of his for smooching. Simon didn't reciprocate. Eventually the busomy babe chased after the object of her heart's desire offering to do his make-up. However the only make-up she was interested in applying to his face was her lipstick during a make-out session.
- A constant mockery/Self-Deprecation point of Andrew Hussie, who has large, pursed lips. While in Homestuck he's drawn without a mouth or nose, his title is still "Huss of Lips", and references are made to his Author Avatar, Dave, having hilariously large lips.
- Johnny Test is told to test out his sisters' Lip Lozenge, designed to give fuller, kissable lips. It works too well.
- An attempt to stop a Zombie Apocalypse in one episode of Adventure Time instead created a formula that inflated the zombies' lips.
- The infamous "Duckface" is an unintentional example. It is done by girls and sometimes boys by puckering their lips to make them look more attractive, but overdoing it, the result looking something like a duck's bill. It's become almost a Running Gag on sites like Facebook.
- On Nick Arcade, landing on an enemy space in the Cape Cosmos board would result in Mikey being approached by the Smooch Aliens, a pair of round aliens with pigtails, cyclopic eyes, and big, red lips, who would give him slurpy kisses.
- Data East Pinball's Tales from the Crypt shows a ghoulish zombie on the playfield who has grossly exaggerated red, puffy lips.