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- Johan Liebert from Monster combines this with Where I Was Born and Razed. Repeatedly.
- Rosemary from Ashitano Nadja didn't start as this, but she got in the role very quickly after a major Freak Out caused by seeing that her old friend Nadja was the one living her formerly innocent dream.
- While Orochimaru of Naruto didn't defect from Konoha until around 10 years before the start of the story, the Third Hokage noticed there was something unsettling about him after he lost his parents. He largely turned a blind eye to it because of his talent.
- Mukuro from Katekyo Hitman Reborn! is adopted by another family but soon uses the man taking care of him to kill off the entire family.
- Exploited in The Good Son: the evil one is the kid with both parents, but he manipulates the people around to make it look like his innocent, half-orphaned cousin is the bad seed.
- The Omen (1976). The boy Damien is an orphan substituted for the couple's real child, who died shortly after birth.
- The antagonist of Thor and The Avengers (2012), Loki, had this trope forced on him, seeing as he was lied to his entire life about his parentage. He didn't become evil until he found out he was adopted.
- The novel Hogfather features Mr. Teatime, who was taken in by the Assassin's Guild after both his parents died suddenly when he was very young. In the words of guildmaster Lord Downey, "In hindsight, perhaps we should have looked into that a bit more."
- Harry Potter:
- Lord Voldemort was raised in a Muggle orphanage, where he spent his free time bullying the other children in a variety of cruel and magical ways. He later became a Self-Made Orphan by tracking down and murdering his muggle father and paternal grandparents (and framing his maternal uncle for the deed).
- Harry himself is an aversion, as is Teddy in the last book.
- Heathcliff in Wuthering Heights. His Freudian Excuse is relatively strong, but at any rate, he ends up a usurping beast of pure spite, and his intentions are just that.
- Discussed in A Brother's Price. In a case of Deliberate Values Dissonance, adoption is seen as "a hidden evil". When a family commits treason, if it's not believed to be divided then every member down to the youngest is killed to prevent a Cycle of Revenge or You Killed My Father situation. There is treason in the book, and while Ren does not want to kill her five-year-old 'niece' Eldie, her sister ruthlessly reminds her that none of the child's relatives will take them, and if they take the child, Eldie will eventually know why their family was killed and turn on them.
Live Action TV
- Little House on the Prairie: Nancy Olesen, given her extreme behavior issues and destructiveness. Although it is possible, even probable that Nancy has some very dark secrets in her past, the main reasons given for her extreme destructive, mean behavior center on her being moved from orphanage to orphanage due to her behavior problems (resulting in an unstable life) and the death of her mother while giving birth to her (a condition that today is known as pre-eclampsia). Indeed, in her first episode, Nancy – who deep down likely knows why her mother is not part of her life – claims she was abandoned by her dear, sweet mother.
- CSI has the very Creepy and Insufferable Genius Hannah, whose parents have died (the details are never explained) by her second appearance. In her first appearance she gets her brother off a murder charge (albeit an accidental one). In her second she frames him and Drives Him To Suicide to keep him dependent on her. She also Breaking Speeches Sara, possibly contributing to her decision to go on a vacation to the rainforest.
- Supernatural has a young girl in the first season who not only cut the throats of her biological and adoptive families, but made it look like her adoptive father did it. Then she did it to people who owned a painting of her adoptive family.
- Considering how ugly that painting was...And that they knew it has a bad reputation of previously deceased owners...Maybe they had it coming.
- Alexander on Smallville is an infant clone of Lex Luthor. Tess Mercer hoped that by raising him to be good, she could save him from the Luthor legacy. Unfortunately, Alexander has all of Lex's memories, and is aging very rapidly to boot. As of "Luthor" he's gone AWOL, and is out there, somewhere, plotting revenge on her and Clark. Eventually inverted, since he ended up losing these memories and becoming Superboy.
- During a questline in World of Warcraft Alliance players encounter Hope Saldean, a friendly young lady who was adopted by the Saldean couple four years earlier. While Hope seemingly spends much of the Westfall-storyline feeding the homeless, a shadowy figure is gathering the old members of the Defias Brotherhood. In the end Hope reveals herself to be Vanessa Vancleef, the daughter of Defias leader Edwin Vancleef, who has been secretly plotting against the Kingdom of Stormwind the whole time.
- Whole bunch of them in Rule of Rose, though all have their own Freudian Excuse, and you will end up feeling more pity than loathing for them by the end. Wendy tops all the others by making the others kill Jennifer's dog, and then setting a serial killer loose on the orphanage. All because Jennifer didn't love her alone.
- Clive in Professor Layton and the Unwound Future, who lost his parents in a time machine explosion 10 years ago, and schemed to take vengeance on the people responsible with the money he inherited from his adoptive mother.
- In Mission Critical, you find The Mole's secret diary, where he explains his reasons for betraying The Alliance to the UN. His parents were scientists. He and his brother were visiting them at work one day, and a batch of nanites programmed to clean up oil spills was accidentally let loose, and his parents (or rather, all oils in their bodies) were eaten from inside out right in front of them. From that moment, he decided that the UN was right in limiting technological development.
- Family Guy spoofs this with Stewie's pet turtle.