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Anime & Manga
- Weird variation in Dragon Ball, in which Goku— who is very much NOT The Smart Guy— gains the power to read minds by training his muscles in high gravity. He uses it maybe twice in the series to get caught up on current events without a tedious Info Dump, other than that the ability is never mentioned again.
- The Leader in Ultimate Marvel developed telekinetic abilities as a result of the experiments to increase his intelligence.
- X-Men Film Series: Professor Charles Xavier is highly intellectual and he's the greatest telepath on the planet.
- The far future villain in The Time Machine (2002) has a massive brain that extends down his back. He uses it to control the beasts that prey on the humans.
- In The Lawnmower Man, when Jobe get his intellect increased up to - and possibly beyond - genius level, he also gains a wide variety of worryingly strong Psychic Powers.
- In the film version of Matilda it's said she uses a greater portion of her brain then most people, and so she keeps her powers at the end of the film.
- Matilda Wormwood, a girl from Roald Dahl's Matilda who had read Moby-Dick before kindergarten. Her Mind over Matter powers are stated to be because she's so bored and has no other way to use her brainpower. Once she is being challenged in school, they disappear.
- Once AM in I Have No Mouth and I Must Scream gained sentience, he also gained psychokinesis.
Live Action TV
- Brainchild of the Global Guardians PBEM Universe combines superhuman intelligence with powerful Psychic Powers to make his way as a supervillain. Likewise, The Brain combines lots of smarts with telepathy.
- In The Adventures of Jimmy Neutron: Boy Genius, Jimmy's normally ditzy friend Sheen gets his intelligence increased with Jimmy's Phlebotinum and gains telekinesis.
- In Big Guy and Rusty the Boy Robot, there was Dr. Neugog, who got mutated into a borderline Eldritch Abomination when a spider got between him and an invention of his that would have allowed him to read minds. After being mutated, he had the power to suck people's brains out, and add them to his own. The more brains he had sucked, the greater his intelligence became, and he eventually developed psychic powers. Later, Dr. Donovan's nephew Pierre had the same thing happen, but without the Body Horror, and it was later reversed.
- When Mandark first appeared in Dexter's Laboratory he was shown to be telepathic, to underline the fact he was smarter than Dexter (that's before Diminishing Villain Threat settled in, of course). This is used to an eerie effect when, in his first spoken line, he answers the question the teacher was going to ask next.
- In the episode "Heavy Mental" of Darkwing Duck the technogadget of the day zaps people and increases their brain power, complete with inflating head and psychic powers, which are mainly telekinesis and clairvoyance. Toward the end of the episode the General Ripper zaps himself and takes things up to eleven, turning himself into pure thought.