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Anime & Manga
- This is what happens in Naruto after Sasuke meets again his long lost and hated big brother Itachi, whom he swore to kill after the latter slaughtered every single member of their clan, save for Sasuke. The meeting can be resumed as No-Holds-Barred Beatdown meets Mind Rape. When he recovers (physically), Sasuke becomes obsessed with revenge while reporting his frustration upon Naruto (because of the latter's progress). Meanwhile Sakura cannot do much but witness this. Sasuke leaves the Leaf not long after, to be taught by the current Big Bad. Bringing him back becomes his former True Companions' goal for the second part of the tale.
- This was threatening to happen to the Straw Hat Pirates in One Piece when they reached the city of Water Seven. Robin disappeared for reasons unknown to any of her crewmates, and Usopp had a falling out with Luffy and left on his own accord. The rest of the time he was there, Luffy was trying his hardest not to let the rest of the crew disband. Averted in that he succeeded in keeping the crew together and eventually got Robin and Usopp back too, which were the main driving forces of that part of the series.
- This also forms part of the plot of the sixth movie. The bad guys manipulate the crew members into distrusting each other, and eventually absorbs all of them except Luffy.
- In Air Gear, the old Sleeping Forest was shattered when Kilik and Sora had a falling out over the Sky Regalia. Since then, Kilik severed all contact with his former teammates with the exception of the only one who remained neutral, and the rest of the team members scattered: Spitfire decided to reclaim his title, Rika retired, Sora was crippled, Falco became a recluse, Black Burn became a drunk and never involved himself with A-Ts without a disguise, and Dauntless seems to have disappeared.
- In Bratz: The Movie, head girl Meredith is set upon driving the Bratz girls apart; after two years, she has succeeded in making them part of her pre-defined cliques, and they can barely speak to each other any more.
- Such a case could be argued for Andrew Detmer in Chronicle, though the fault also lies on his father for Andrew's Start of Darkness.
- It's very common for animated films to have this happen shortly before the climax, particularly the works of Pixar and Dreamworks. Either the personality conflicts that drove the tension earlier in the film will be reignited, or a lie one of the characters had told the other will be revealed, making them go their separate ways. Of course, the protagonists will always remember the value of their friendship in time to to reunite and stop the Big Bad.
- In Equestria Girls, the reason the human counterparts of Twilight's friends hate each other when they used to be friends is because Sunset Shimmer drove them apart.
- In book seven of the H.I.V.E. Series, the betrayal of Laura leads to the capture of Nigel, Laura, Tom, and Penny. The rest return to the H.I.V.E., but are split again when Otto is expelled. At the end, the main cast is within three groups: Nigel, Tom, Penny, and Laura at the Glasshouse, Otto, Raven, and H.I.V.E.mind out in the world, and Shelby, Franz, Wing, and Nero still on the island.
- A lot of the Horus Heresy consists of this happening to everyone from random line troops to Adepts of Mars to the eighteen remaining sons of a Physical God. Most notable is the Mournival, the Four-Temperament Ensemble Horus has as advisors, which breaks like fine china when everything goes to hell and leaves Garviel Loken and Tarik Torgaddon on one side and "Little Horus" Aximand and Ezekyle Abaddon on the other; they do not get back together, and in fact end up some of the most passionate enemies of the entire civil war, culminating in an entirely sincere effort to kill each other.
Live Action TV
- In The Answer for Persona 3, after the protagonist dies, Yukari grows adamant about reviving him/her by going back in time. This was so risky that it would've prevented the Big Bad from getting sealed, risking the entire world once again to another battle that the team wouldn't have won in any other way than if the protagonist hadn't died. Thankfully, it doesn't come to that, and Yukari gets better, but only after a fight with the rest of the team (Mitsuru sided with her, though).
- In Shin Megami Tensei IV, in the beginning, your party of 4 become true companions, by the end, they all have opposing views and at least 2 of them will be killed in the fighting.
- In Knights of the Old Republic, Bastila Shan gets tortured into serving the Big Bad, and she confronts you in the Ancient Temple on Lehon. If you choose to side with Bastila, Jolee, Juhani, Mission and Zaalbar get killed, while Carth runs away into the Lehon Temple. The droids and Canderous are the only ones that remain with you, while Bastila becomes your apprentice. Contrast with the alternate path, in which all the above characters survive, and even Bastila can be redeemed if the player character is in a relationship with her or has high enough Persuasion. Note that Bastila isn't the Bond Breaker; it's you.
- Dragon Age II has Anders, who is gradually corrupted by the demon of Vengeance until he blows up the Kirkwall Chantry, triggering the events of the endgame and driving apart the True Companions who have been together for six years.
- Note that in the optimum ending, only two characters are mutually exclusive. Sebastian and Anders himself can NEVER be on the same side. Either Anders dies, or Sebastian threatens to raise Kirkwall.
- Shows up in the backstory of The Order of the Stick. The Order of the Scribble, united mostly by their goal of closing down all of the rips that allowed the Scribble to enter the world, are able to stick together long enough to accomplish it. Unfortunately, pre-existing issues, the death of one of their own and disagreements on how to best guard the gates lead to a VERY ugly argument, causing them to split up and watch over one of the gates individually. We see that for some of them, even years later, the feelings haven't died down and some of them would never be able to trust the others ever again.
- An impressively realistic example comes from the Teen Titans episode "How Long Is Forever". After Starfire goes through time while fighting the token villain of the week, she disappears from the rest of the Titans' lives. What was a few seconds for her, were twenty years for the rest of the team, and none of them handled her absence well, since she balanced them out.
- In the 2003 Teenage Mutant Ninja Turtles show, Donatello was warped into an alternate future where he had disappeared for 20 years. The Turtles were disbanded, which led to the Shredder succeeding in world domination, and Michelangelo flat-out tells Don it's because he wasn't there to balance them out. Both this and the Teen Titans episode are also variations on It's a Wonderful Plot.