Apex from Avengers Arena. As with the Hunger Games example in "Literature" (a very likely inspiration), when you're in a story about people being forced to fight and kill each other, who better to root against than the only one going along willingly? She's also a completely new character, and thus one without a fan base, to ensure nobody will like her.
However, Word of God claims she is not a villain, the book is trying to give her some nonexistent depth to gain people's sympathy at few points, but she's the only real-life minority out of Braddock's Academy kids and the only one who is willingly killing others - giving it a strong transphobic and lesbophobic subtext. Her plans are stupid and outright self-defeating when the book tries to show her as a Chessmaster, and she varies between being pretentious and whiny. And Marvel once tried to claim fans Love to Hate her, which, quite frankly neverworks. All of which is making her more of The Scrappy than this trope.
Marvel Graphic Novel #18: S.H.I.E.L.D. Agent Roger Dooley is placed in charge of bringing in Jennifer Walters aka She-Hulk for an examination to make sure she doesn't become a hostile menace like her cousin. The first instance of Dooley's jackbooted thuggery is when he sends a team of agents in Mandroid Armor to arrest She-Hulk while she's on a date with her boyfriend Wyatt Wingfoot. When She-Hulk resists, citing their lack of a warrant as a reason, Dooley resorts to holding Wyatt hostage to make Jen comply. Dooley then orders Jen to be publicly strip searched by S.H.I.E.L.D. agents much to the disgust and anger of Dum Dum Dugannote Dugan points out that a S.H.I.E.L.D. strip search is supposed to be done in a private cell and by an agent of the same sex as the suspect. When Dugan is sent back to Washington after filing a complaint against Dooley, Dooley continues to abuse his authority by subjecting Jen to a series of painful and invasive examinations which he records with the implication of doing so for sexual perversion. He also makes a few racially insensitive comments to Wyatt who is Native American. Dooley may have been a one-shot antagonist but he proved to be an utterly depraved human being.
Red Skull. A surviving member of the Nazi Party and Captain America's most personal enemy, he is without a doubt Cap's most despicable, immoral, pure evil enemy. Possessed of all the worst traits of Marvel's sundry villainous characters and none of their redeeming features, he is reviled even by other villains, especially Magneto and Doctor Doom; even The Joker (in Batman & Captain America) hates his guts. By any measure, that's a whole other level of bad. Consequently, few things are as cathartic as seeing Captain America beat the ever-loving snot out of him. Notably, this is his role in Secret Empire; Hydra's Steve Rogers and his associates (such as Baron Zemo) have shades of Well Intentioned Extremism or are at least somewhat entertaining to read about, which they have to be because the reader is stuck with them for most of the event, but Skull is only there to set the event in motion by setting up a Cosmic Retcon that makes Captain America retroactively become Evil All Along and a member of Hydra, only for Hydra-Cap to enact an Eviler than Thou, pull his organization out from under his feet and give him a Karmic Death.
The Punisher: Most of Frank Castle's enemies are horrifically loathsome, making their ultimate demise all the more satisfying:
Colonel De Sade, the sadistic former interrogator for "the company" during The Vietnam War.
While the other members of V.I.G.I.L. were Sympathetic Inspector Antagonists, Lieutenant Taylor Blackwell was an insufferable Smug Snake who freely engaged in Police Brutality. After he suffered several humiliating defeats at the hands of the Punisher, Blackwell finally snapped in The Punisher: Suicide Run; after the Punisher is falsely reported deceased, Blackwell vents his anger over this by torturing the Punisher's captured allies, Lynn and Payback, at one point laughingly stating, "What do I care?!" when Lynn started screaming that he might kill Payback. When his partner tried to stop him, Blackwell shot him in the head before pinning the murder on Lynn and Payback. When a newscast mentioned that the Punisher was spotted alive in Laastekist, Blackwell cut the town's power and telephone lines, leaving it to the mercy of both himself and the veritable army of criminals that had descended upon it in search of the Punisher. Blackwell takes the local sheriff's mentally handicapped daughter, Amy, hostage to get the sheriff to hand over the Punisher, orders that the sheriff be shot even if he cooperates, and later uses Amy as a Human Shield while mockingly calling the Punisher weak for being unwilling to shoot through Amy. In his final confrontation with the Punisher, Blackwell starts ranting about how he will track down and murder everyone that has ever helped the Punisher, starting with Amy, while bragging about how being "the law" makes him untouchable and gives him the right to do whatever he wants; the Punisher eventually just blows Blackwell's head off, having become so sick of him that he no longer even cared about the consequences of publicly executing a Villain with Good Publicity.
Nicky Cavella is so sadistic that even other mobsters despise him. It doesn't help the fact that he is a Smug Snake and a Dirty Coward hiding under a tough guy exterior.
William Rawlins is a monstrous CIA operative who made his living as a leech in war zones. He doesn't even have a Freudian Excuse for his actions. All we see of Rawlins is a greedy, cowardly, backstabbing asshole. And for bonus, he's also a racist.
The Slavers, but Tiberiu Bulat stands out in particular. In fact, their occupations as Human Traffickers are the main reason why Castle went above and beyond in making them pay. After all, Slavery Is a Special Kind of Evil.
Vincent Rosa is the son of a Mafioso and a sexual predator who rapes little girls including Frank Castle's childhood friend Lauren Buvoli.
The one-shot "Naked Kill" features a trio of sadistic psychopaths who kidnap women to satiate their twisted perversions. Fortunately, these scumbags get a very satisfying fate.
Spider-Man: Spider-Man's Tangled Web introduces a one-shot villain known as The Thousand, who is just as loathsome as he is horrifying. Originally Carl King, a particularly nasty bully to Peter Parker, he transformed into a colony of a thousand spiders that could crawl into a human's body, devour them from the inside out and then wear their skin like a suit after eating the radioactive spider that gave Parker his powers. He goes through several bodies each year to grow stronger, with some of the victims being children, and hunts down Spidey for the sole purpose of stealing his body and taking over his life, under the belief that he should have been Spider-Man instead of Peter Parker. Even among Peter's worst foes like Norman Osborn and Carnage, the Thousand has none of their bravado or even slightly sympathetic qualities. He's a vicious, entitled bully who kills and torments for the pettiest of reasons, and a vile, predatory abomination both literally and figuratively. This just makes his ultimate demise of being electrocuted and having his last spider squished by a random passer-by all the more satisfying, and he has never reappeared since.
As well, we have Henry Peter Gyrich, theObstructive Bureaucrat, who committed many atrocities (directly and indirectly) because of Fantastic Racism (he was one of the people behind the Sentinel Program, at least on The '90sX-Men: The Animated Series TV show), because of thinking he could do better (restructuring The Avengers by pretty much tossing most of the membership out on the street), and for the sake of saving face (cloning MVP when he was killed in a training accident). This last one, mixed with saying exactly the wrong thing to Iron Man, finally got him fired. Alas, it wasn't enough to keep him away forever, and Gyrich eventually returned, just as smug, self-righteous and annoying as ever.
In that vein, the X-Men have a lot of foes fans love to hate which were likely thought up with this in mind. The Friends of Humanity are often viewed by fans the same way most folks do The Klan, while the government of Genosha was even worse. In fact, many such anti-mutant hate groups have appeared throughout the comic's history, often to give Magneto and his Brotherhood someone to clash with while being the sympathetic parties.
Among the mutant heroes and villains, however, no character qualifies for this trope better than Fabian Cortez. The Deceptive Disciple who pretty much single-handedly put Magnetoback on the villain track, Cortez is a smug, self-absorbed excuse for a man who shamelessly sucks up to Magneto and later Exodus only to try and stick the knife in their backs every chance he gets. He suckers dozens of mutants into believing an ideology he builds around the assumed-dead Magneto (who he assumed he had killed himself) and freely admits he sees all his followers as nothing more than sheep to make his own life easier. He spouts loyalty to his species while secretly murdering fellow mutants for points in an arbitrary competition, boasts of the "mutant harem" he plans to build when he has triumphed, and casually abandons his own sister to die in the very first story he appears in. It's hard to be more loathsome than the likes of Sabretooth or Mr. Sinister, but Cortez pulls it off with revolting aplomb.
In Ultimate X Men, the roles of Magneto and humanity are shifted. Magneto is the leader of an openly terrorist organization, aiming to destroy the whole human race by any means necessary, from plain terrorism to massive death and destruction (in his first arc he laid waste to the White House and almost killed the president of the US on live television, and in the last, Ultimatum, he caused natural disasters on a worldwide level). The reactions of human organizations seem like a light and justified self-defense in comparison. And, just in case, he is also a Politically Incorrect Villain, likes to kick dogs, and complement his massive evil actions with Evil Is Petty moments.
