Nightwing was captured by Shrike, a rival with a grudge who was one of the best assassins in the world. When it was finally time for Nightwing and Shrike to throw down, the former completely ignored the latter and kicked his ass with his back turned.
His run-in with Cassandra Cain's Batgirl (after a Big Damn Heroes moment where she bailed out Robin) went no better:
Batgirl: "Your arm is broken, you're bleeding to death. I'm untouched, haven't... broken a sweat. I know what you are going to do next and it... bores me. You are going to the hospital, will you be... standing up or lying down?" Shrike: (charges forward with blade in good hand) "GRAAAAHHH!!" Caption (Batgirl's thoughts): He chose lying down.
Shrike may have billed himself as 'one of the best assassins in the world', but it was pretty obvious that at League of Assassins meetings, he was the one they made get up and go outside to pay the pizza guy. He showed up later in Lady Shiva's class, which, to be fair, means he can't have sucked too bad, but he was clearly not going to get straight-As at assassin school
Cassandra Cain (Batgirl III) had a number of battles like this, at least before her epic derailment. One of the best would likely be when Spoiler convinced her to spar together. The result was a full page Curb-Stomp Battle that left Stephanie bruised up and vomiting on the ground.
Full page series of battles. Some done while Cass was sitting down.
The end of Empowered vol. 4... dWARF didn't even get a hit in.
Willy Pete vs nine/ten of the Superhomies, Willy kills them all in a blast of fire so powerful it was like hitting them with a nuke.
Julia Diggers vs Zero in Gold Digger looked going in to be a rough fight, Armsmaster vs Elite Ninja. Then the fight starts by her avoiding his every move while he's invisible. Rendering him visible, he activated an array of traps. She blocked. Activating an enchantment to reduce his mass and multiply his speed. She anticipates and absorbs his attacks. Backing off to regroup, she attached a wire stolen from one of his earlier traps and yanks him into a master strike! Literally the only reason he didn't die on the spot was because he was already undead.
Julia Diggers gets a couple of these. Vs Serpentus, who couldn't be hurt without killing others through a magic link and in possession of powerful magical weapons, she outmaneuvered him, stopped his attacks with magic-resistant dwarven chains, and tied him up with said chains and attached them to the architecture, literally turning him into a Load-Bearing Boss.
Theo Diggers vs Tanya consisted roughly of him packing her into a sphere using magic.
Madrid vs Natasha. It turns out vampires are less scary when you can open a portal to the sun.
A villainous variant appears in Watchmen when Ozymandias effortlessly beats down Rorschach and Nite Owl at the same time.
See also: the complete thrashing he hands the Comedian at the beginning. Both fights are even more brutal and one-sided in the movie.
Also, Dr. Manhattan's involvement in The Vietnam War. There aren't many stranger ways to die than having your atoms estranged from each other by a blue giant in a speedo. Several of the Vietcong ended up wanting to surrender to him personally.
Marvel villain Bullseye was on the receiving end of an absolutely epic one of these when he recklessly tried to kill American Eagle, a super-powered Native American who really wasn't in a good mood at the time. After pointing out to Bullseye that there's a big difference between going after unpowered normal types like Daredevil and someone like him, who both has super strength and doesn't hold back when using it, American Eagle proceeds to beat the complete and total shit out of Bullseye. It's a miracle he survived. Bullseye has since given American Eagle a very wide berth.
In an early volume of Preacher, Cassidy, who we had just learned was a super-strong vampire, fought against the Saint of Killers, an invulnerable immortal capable of murdering dozens of police officers. We had no idea how the two of them compared, but it became pretty clear when Cassidy punched the Saint and his hand broke.
Heck, any battle involving The Saint of Killers. The man is a walking curb-stomp machine. Later in the series, he destroys an entire unit of tanks. Even later, he personally kills damn near every Grail soldier, to the point that said soldiers had to climb over the mountain of bodies just to see him. The Saint eventually curb-stomps God himself at the series' conclusion.
The fight at the end between Cassidy and Jesse seems like it's going to be one of these, Cassidy is a super-strong vampire who's taken being machine gunned and shot through the head without losing consciousness and Jesse's just a guy with a good right hook. It is. Jesse totally demolishes Cassidy and goes into a "The Reason You Suck" Speech meanwhile, explaining that he had to deal with this since his youth and knows how to use technique to defeat Unskilled, but Strong.
Wolverine vs. the Mafia in one storyline. A bunch of ordinary guys with guns vs. a mutant with a Healing Factor, about a century of combat experience, and adamantium claws and skeleton? The entire story is pretty much a Curb-Stomp Battle.
When Mara Jade had a run in with one of the Emperor's elite guards, who she promptly smacked down with one punch (because she's just that awesome).
In Exiles, they spend two or three pages building up a fight between Mimic and an alternate universe double of Captain America. The fight is for the Skrull Gladiator Championship, which is the Skrull equivalent of the Superbowl. The actual fight lasts for two panels, with Mimic, a Swiss Army Knife of mutant powers, unleashing the optic blasts that he borrowed from Cyclops. Mimic then flips the crowd the bird, and walks out of the arena.
The fight between Bane and Batman in Knightfall is definitely this, ending with Bane snapping Batman's spine.
Jean-Paul Valley, taking up the Mantle of the Bat, paid Bane back during their rematch. Once AzBats severed Bane's Bottled Villainous Reserve, that was it.
In one 1980s Marvel comic, Iron Man is facing off against the X-Men. One of the mutants uses psychic powers to knock out Tony Stark. Go team... then the Iron Man armor's onboard A.I. kicks in and proceeds to trash the entire X-Men team. That's right, they get beat up by a suit of armor with a sleeping guy inside. Ouch.
The Silver Centurion armor had an edge in both technology and pilot experience compared to the Iron Monger, but Obadiah Stane had remote support, as well as hostages, to keep things even, and his own suit was a brute. When Tony freed the hostages and destroyed the remote support, however, Stane had no chance.
Tony's Stealth suit was good enough against regular, unarmored mooks, despite lacking any offensive weapons. Against the Crimson Dynamo and the Titanium Man, not so much (even with limited repulsors). Let's just say Tony was extremely lucky to survive that battle.
Iron Man was totally overwhelmed by Firepower, whose pilot, Jack Taggert, had been training extensively for the sole purpose of killing Iron Man. Firepower appears to succeed, and in the next issue Tony is willing to leave Iron Man "dead"... until Firepower starts attacking Stark's business interests. Taking the lessons from his last match, the "new" Iron Man curb-stomps Firepower. Most readers will probably assume that Taggert soils himself in the process.
Spider-Man vs Kingpin near the end of the Back in Black arc. For all of his talk, Wilson was entirely over his head in this fight, but in all fairness, it was a Badass Normal vs an enraged Spider-Man.
The same thing happened in One More Day, and the Kingpin had no-one to blame but himself. He had daredSpider-Man to fight him after having his aunt shot just to prove to everyone he was still in charge. The angry hero beat him within an inch of his life in front of the whole prison population, utterly humiliating him.
In fact, if Spider-Man's history has proven anything, when he stops making jokes and gets genuinely angry, that's a very good sign this sort of battle is going to happen, and the villain is going to be on the receiving end.
A good sign of that was back in the early 80s. Black Cat, trying to reform, gets stuck in the middle of a gang war between Dr. Octopus and The Owl. Doc Ock beats her within an inch of her life, barely giving Spidey a chance to save her. Enraged, Spidey races to confront Ock and beats him senseless. His attack was so brutal that, when the enraged web-slinger was done, Doc Ock had developed a fear of spiders and Spider-Man, one that would last for a few years.
Speaking of Spider-Man, when he had to face off against the X-Men in Secret Wars, he curb-stomped the entire roster that had come after him, which included one of maybe three fights between Spidey and Wolverine that was portrayed accurately (here's a hint: Spidey can ignore Wolverine). Wolverine himself stated after the fight that Spidey made the X-Men look like amateurs.
Also from Secret Wars, the newly empowered villainess Titania decided to make the same mistake many, many new supervillains have made over the years and pick a fight with Spidey on their first day on the job. Despite being much, much stronger than him, he wipes the floor with her, tossing her out of the building and causing her to go in to the kind of temper tantrum only a bully of her magnitude could pull off having been brought down several pegs. She had already picked another fight with She-Hulk and did reasonably well; she probably thought that next to her, Spidey was an easy target. She thought wrong.
Another Spider-Man example: he goes up against one of Galactus' former Heralds, Firelord, and it seems that Firelord has the upper hand, because Spidey has self doubts about his skills. Once Spider-Man gets pissed, Firelord is taken out in less than five panels.
Of course, it was after Firelord has just hurt a child and Spidey pretty much went berserk. And quite frankly, every time villain hurts a child in Spider-Man's presence, Spidey will utterly devastate him, the only exception being Lizard, who had evolved and developed new powers, which stopped Spider-Man from trashing him.
A Silver Age example. During the Scorpion's debut he proceeds to hand Spider-Man his ass twice in the same issue, drawing upon superior physical strength and his lethal tail. Spider-Man wises up by round 3 and manages to take Gargan out through tactics other than brute force.
Spider-Man got into another two in Brand New Day, during The Gauntlet arc, first being on receiving end, when Mr. Negative threw him several streets away with one punch and then and delivering, once he found out the Kravinoffs have killed his clone Kaine to resurrect Kraven The Hunter - he goes on a Roaring Rampage of Revenge and the people that almost killed him suddenly go down like flies.
During the same arc, Spider-Man has to save Juggernaut, who has found himself at the receiving end of one of these, with the new Captain Universe delivering.
And there is also Rhino vs New Rhino, which has a large buildup culminating with Old Rhino breaking new one in matter of seconds, and then killing him.
In Ultimate Spider-Man Kraven the Hunter makes this big show of how he's going to hunt Spider-man, and after multiple issues gets the chance while he's fighting Doctor Octopus. Spidey dodges him a for about a page, then slams him to the pavement.
An utterly hilarious example in The Incredible Hercules: The villain drops a Grendel-style monster on the battlefield, with the assumption that Thor and Hercules are too exhausted to fight it. He's right, but he didn't take into account Zeus, who promptly proves that while he may be bite-sized and missing the majority of his memory, he's still the king of the Greek-Roman pantheon. By flattening the monster with one shot of lightning.
Chaos War was full of those - Chaos King killing Nightmare, Impossible Man, Lucifer, Ares, Pluto, Zeus and Hera with no effort, Zeus curb stomping Thor and Galactus and Chaos King curb stomping every single pantheon on Earth. The epilogue in Incredible Hulk featured Zeus giving Hulk one of the biggest beatdowns of his life.
The thing about Scott Summers is that, given the nature of his powers, a fight with him where he knows the fight is happening should logically come down to one question: are you vulnerable to his optic beam? Because if you are, the fight should basically consist of you going down. The nature of Scott's power is such that if he can see you, he's already hit you. So if you can't resist his optic beam, your only plausible options are 'surrender' or 'strike by surprise from behind' or some such tactic.
There was an Danger Room battle between Scott and a depowered Ororo in which Ororo manages to dodge optic blasts and otherwise win the battle.
During Joss Whedon's run on X-Men, which among other things made Cyclops even more badass, Scott utterly wrecked a Sentinel with one blast from his eyebeams. A Sentinel is a Humongous Mecha that is specifically built to kill mutants and normally would give an entire team of X-Men a hard time. This time, Scott stopped holding back — the Sentinel never had a chance.
However, on occasion a villain will use their brains when fighting Cyclops, and use armor made out of ruby quartz (Cameron Hodge for example). Considering that Cyclops' powers don't work on ruby quartz, this turns it into a curbstomp battle for the villain.
One of the most satisfying examples occurs in The Ultimates. Hank Pym is sitting at a bar, nursing a drink after having brutally beaten his wife, Janet Pym. Door opens; in walks Captain America. Cap sits down, listens to Hank explain himself, and then pounds the snot out of Hank. Hank grows to 100 ft. tall. Then the real curb-stomp battle begins. Doubles as a Crowning Moment of Awesome for Ultimate Steve Rogers; the man was born for that particular moment.
Even better, Cap demands that Hank enlarge so Cap can cut loose on him.
The Wife beating itself had started off as an argument that dissolved into mutual combat which quickly became one of these, and that was before Hank called the ants.
The Authority's previously invincible Apollo was subjected to an unexpected curb-stomping at the hands of two members of The Americas (who were a satirical stand-in for the Avengers), Thor and Captain America parodies. The comic contains several panels which allude to man-rape and sodomy, although the authors state that these scenes were deliberately made ambiguous.
Apollo gets his revenge two issues later, when he rips apart entire army of marvel-powerups parodies, including those two that got him earlier. Manwhile Jack and Doctor curbstomps other villaionous versions of Marvel superheroes, with former making city of Paris eat his opponents alive and Doctor turning his opponents bones into cologne.
Later, in issue #22, Seth (the Six Billion Dollar Bastard) curbstomps the entire team. He takes down Apollo with one blast, doesn't give Midnighter a chance to land a single blow, beats the Doctor between panels, takes Swift out before she can even enter the room, steals the Engineer's nanomachines after harmlessly deflecting her bullets, then teleports to Jack Hawksmoor and seemingly swallows him. This would have taken less than the five pages it did if he hadn't taken time to give exposition and make taunts.
A non-violent variation occurs when Superman and The Flash face off in a genuine test of speed. Turns out the Flash likes to hold back when they race for charity in order to keep things entertaining for the folks at home. When it comes right down to it, he leaves Supes in the dust.
It's a Retcon. Those races were between the Silver Age versions of those two characters back when Superman really could keep up with the Flash (life just wasn't fair for the rest of the JLA back then). There had been one official Post-Crisis race between Wally and Superman but, while Superman had been reduced in power, so had Wally and Wally only barely won. It was only when Barry returned at his full power level that it had to be explained that clearly, Barry must have been holding back during all those races (which is odd given that some of those races did have serious stakes and weren't just for charity.)
The Flash versus Quicksilver is basically a joke ever since Wally got his full powers back in the early nineties. In their first fight, Wally was owning Pietro until he had to stop to save some kids and Pietro jumped him. But Pietro had a moment of conscience, giving Wally more than enough time to drop him.
In one of the early races, both Superman and the Flash learn that a group of mobsters are manipulating the outcome of the charity race in order to make money on bets. Not only do the two heroes ruin the betting pool, they team up to administer the more usual type of curb-stomp on the mobsters.
A bit more balanced in their encounters in JLA-Avengers. The Speed Force (Wally's power source) doesn't exist in the Marvel universe so the winner of the match depends on which universe they're fighting in even after Wally starts packing a Speed Force battery for his trips to the Marvel U.
Damian and Tim have had a strained relationship ever since the former was introduced, sucker punching Drake out of jealousy. After years of teasing the hostility between the two, they finally had it out in Red Robin #13 and Damian got the ever loving crap beaten out of him.
Averted in Batman and Robin , if you`ve read some of the confrontation between Tim and Damian leading up to this this one you probably expect another Curb Stomp battle , but Damian actually seems to win during the first half of the fight before Tim gains the upper hand again.
World War Hulk: X-Men is basically the Hulk handing one of these out to every X-Men team over the course of three issues. Until he runs into a fully powered Juggernaut, the most they can do is slow him down, and even then not for very long. Unfortunately, the Hulk was madder than he'd ever been before, which made him strong enough to stop the unstoppable Juggernaut.
Hellblazer: Averted in a badass manner. During the most-beloved Dangerous Habits storyline, John Constantine was dying of cancer and when things can't get any worse, gets the wrath of Satan aka The First of the Fallen (who was by the way omnipotent). When the First was already going to collect his soul in the eve of his death, and to be tortured so brutally by none before, John suprises him by revealing he has sold his souls to two other Devils. He then gives the First the bird.
Mr. X vs Quicksilver in the Siege finale. Mr. X (a Wolverine villain) discovers that his particular schtick - reading his opponent's mind so that he knows exactly what move said opponent is about to make - is completely useless against someone who can move at the speed of sound. He knows what Quicksilver is about to do - namely break every bone in his body with a chunk of metal debris - but he can't possibly react fast enough to prevent it.
Even better - Mr. X was wielding Odin's Spear, which has been said to be as powerful as Thor's hammer or even more. And he still lost.
Mr. X actually gave one to Wolverine the first time they fought.
Scott Pilgrim's fights with evil Ex 2 and 3 turned into this, with Scott being entirely outmatched for the both fights. Lucas Lee (2) was destroyed doing a highly impossible skateboard stunt, and Todd Ingram (3) couldn't be defeated till he lost the rights to his Vegan powers.
At the start of The Death of Superman, the monster Doomsday is attacked by the entire Justice League (sans Superman). When Supes showed up, the League was shattered.
There's really no other way to describe the "battle" between Superboy-Prime and the former/current Teen Titans in Infinite Crisis. The Titans never had a chance.
Thor's entire side of the fight consisted of two blows from Mjolnir and a large lightning bolt. Thor even explains that one reason he stomped Stark so badly is that in Katrina-ravaged New Orleans, there is no need for him to hold back.
And the whole fight is summed up with one quote from Thor: “Give your orders and ultimatums to those who choose to obey, or are too cowardly to fight. NOT TO ME. Or learn again the difference between a god of thunder and a mortal man in a metal suit!”
Marv vs. Manute in Sin City. One would think that the fight would be epic since they're both very similar, physically. You'd be wrong. There's a reason why Manute has a fake eye in later stories.
Squirrel Girl is a champion at this trope. Her most famous victories occurred off-panel, but in the Deadpool/GLI Summer Spectacular, we see her give Deadpool the beating of his life in the space of a single page.
In #4, a massive group of Marvel heroes (including Hulk, Iron Man, Thor, Firelord, etc.) arrives to fight the supremely empowered Thanos, who makes the odd decision to only use the "Power" Gem during the fight thus giving the heroes a slight chance. He then proceeds to kill everybody (but they get better). In #5, he then takes down the entire Marvel Cosmic contingent.
Marvel Universe: The End has Thanos, being empowered by Heart of the Universe, facing every single being in the Marvel Universe, killing them all, then taking down the Abstracts and Living Tribunal.
Annihilation has Drax vs Thanos, which lasted one panel - enough time for Drax to rip his opponent's heart's out and for Thanos to find it interesting.
Uber Averts the traditional bloodless superhero fights by depicting literal curb stomp battles between normal human soldiers and the titular Nazi superhumans. The "tank"-class Ubers bloodily rip ordinary soldiers and even tanks apart with their bare hands; the "battleship"-class Ubers annihilate entire armies in seconds. When the Allied forces get their own superhumans, several Nazi Ubers are literally stomped to death in gory fistfights, but the first Allied "battleship", Colossus, is eviscerated in seconds by the much more powerful German Uber Sieglinde.
Pretty much any fight in the Astérix comics that involves a) Obelix or b) any Gaul who has taken some magic potion (usually Asterix) will qualify as one of these.
And then there's The Punisher. Just a few examples out of many:
Frank actually specializes in handing these out, particularly in the MAX stories written by Garth Ennis, where Frank carefully plans his missions to be these because he knows he's pretty much always going to be outnumbered. Therefore he relies on surprise, people reacting without thinking, and bringing the biggest guns he can carry. In one story, he kills an aging and invalid mob boss during a party, then evacs out the back while everyone is stunned from the gun shot. He's mentally counting down how long it will take for the shock to wear off, tempers to flare, guns to be drawn, and people to start pursuing him. At the exact moment he thinks "here they come", a horde of goodfellas burst out the door after him. Only to find out they're in the kill zone for the M-60 firing nest he'd carefully set up and positioned beforehand.
In one story arc, he's on a covert mission to Russia for Nick Fury (long story) and eventually comes across a martial artist half his size who curb-stomps him. But when the same guy then threatens the life of a little girl Frank swore to protect, Frank gets up off the floor and curb-stomps him, to the point where he has to force himself to stop because he's frightening the girl. Frank was able to get his second wind because the girl reminded him for a brief moment of his long-deceased daughter.
Also, in the tale of how Frank infiltrated Riker's Island Prison to kill the Mafia criminals responsible for the murder of his family, he takes a truncheon to one of them and repeatedly bashes him in the head over and over and over. It's not pretty.
One of the all-time scariest curb-stomps in terms of sheer brutality happened when Frank went after a human trafficking ring. One of the masterminds of the operation was a woman. Frank confronts her in a skyscraper office, and repeatedly tosses her against the window again and again until the window comes loose and she falls dozens of stories to the street below. Keep in mind that this woman was directly responsible for the brutal physical and sexual degradation of numerous young women, including one whose baby daughter was used as leverage against her good behavior. She had it coming.
Frank ends up on the receiving end of one of these in the Joss Whedon written arc of Runaways. He's about to kill the kids for working with the Kingpin only for Molly and her Super Strength give him the single most painful nutshot of all time. Frank's role for the rest of the arc when he appears is to hold his ground, trying desperately not to pass out, hilariously.
If you're a normal person and you face one of the Minutemen, nice knowing you.
In Dallas Barr, this happens to a task force hastily assembled to take back a space station, from a lunar colony where no one has military experience. They should really have read the chapter about maintaining radio silence in their handbooks.
Magneto's first two battles with the "new" X-Men (the 1975 team) were long enough to be interesting, but with two of the X-Men helpless against him (Colossus and Wolverine are both very metallic), they still get thoroughly stomped. They carefully plan their third battle; one might argue they have the upper hand when the game is called on account of volcano, but it's still a close one.
It's surprising that this doesn't happen more often, but in 1993 Wolverine was attacking Magneto, so Magneto just said "Fuck it." and tore all the adamantium from Wolverine's skeleton. Wolverine survived thanks to his Healing Factor, but it was brutal.
Superman often doesn't get mentioned in these because it is simply assumed he gives them regularly, even so, he deserves mentions:
Superman vs the Auth.. erm vs the Elite. To educate the Elite, a new group of violent and cynical superheroes who want to kill him, Superman gives them such an insane beating that the last one standing really believes Superman has crossed his sacred line and killed all of his teammates. Then Supes proceeds to show said last man standing exactly how powerless normal people feel when reckless metahumans treat them as their playthings. It's worth noting that Supes didn't actually kill any of them, but rather knocked them out using various methods, meaning that while taking all of them down seemingly effortlessly, he was still holding back.
Right after coming back "from death" and regaining his powers, he easily curb-stomps Cyborg Superman, who had killed thousands of people by destroying Coast City while he was gone. Superman punches straight through his chest, impaling him on his arm. Then vibrates his arm at super-speed, disintegrating the wretched android.
Not to mention all the "Superman turning slightly evil by Polka Dot Kryptonite" incidents. Did Green Fury (now "Fire"), the Brazilian superheroine, hope on Wouldn't Hit a Girl? Not on Polka Dot Kryptonite, m'am! She got stomped like the Brazilian soccer team 2014...
In Last SonLex Luthor is ambushed by one of General Zod's guards, during an Enemy Mine with Superman. Luthor proceeds to use Green Kryptonite gas to choke the guard, burns off most of his skin with red solar radiation, and then puts a bullet through his head, gloating the entire time. The rest of his Superman Revenge Squad (composed of Metallo, Parasite, and Bizarro) do the same to the rest of Zod's forces.
During that time Superman was dead, there was the moment where the Cyborg Superman shows his true colors, shooting the Eradicator in the back, then shooting him in the head. He doesn't give him a chance to fight back.
Superboy vs. Superboy Prime in Infinite Crisis. Superboy has weaker versions of most of the modern Superman's powers, while Superboy Prime could literally punch someone so hard their ancestors could feel it. In a subversion, Superboy wins anyway in a Dying Moment of Awesome by tricking the less-experienced Prime into letting Superboy destroy the Maguffin. He lost the fight, but won the objective.
In The Sandman: Season of Mists, Azazel attempts to devour Dream. Unfortunately for him, Dream is one of the most powerful beings in creation and they're in his realm, where everything bends to his will. Azazel ends up in trapped in a jar in no time at all.
In Miracleman #3, the eponymous Flying Brick is attacked by a super-strong opponent, calling himself "Big Ben". Miracleman impassively waits to see what his new opponent can do, never attempting to defend himself. All of Ben's flying kicks and punches fail to have an impact. Ben next resorts to throwing boulders at Miracleman, and then uproots a tree and uses it as a club... to no effect. Noticing that Miracleman has yet to move, Ben calls for him to fight like a man. In response, a single slap by Miracleman has the effect of Punching Ben Across the Room and to a nearby forest, where his landing leaves an impact crater on the ground. Ending the "fight", and knocking Ben out for an hour (the exact time between the knockout slap and the point he wakes up is recorded for the reader's convenience). When he does wake up, the Super Tough Ben discovers he lost several teeth and now sports a swollen eye.
Not that Miracleman isn't exempt from receiving these. His 'fights' with Kid Miracleman involve his former sidekick using him as a punching bag, and having almost no trouble with him. Justified as KM has had MANY more years of experience with his superpowered body.
Superman has one with Apollo in Superman/Wonder Woman. Apollo, backhanding Superman, boasts Superman cannot defeat him because he is a god. Then, he hits Superman with a solar blast. Supercharged with solar energy, Superman throws Apollo around.
During the first Batman Vs. Predator mini-series, Batman's first encounter with the alien hunter is so lopsided that the only thing that saved Bruce from being the creature's next trophy was the Batmobile.
X-23 vs. Stryker's Purifiers when they assault the Xavier School in New X-Men. The adults (including Emma, Cannonball, and the Sentinel ONE squadron) are rendered completely ineffective. Of the kids, only Dust is able to put up more than a token defense, but even she is overwhelmed. Then Laura arrives on the scene, and tears the Purifiers to shreds.
Naturally Up to Eleven for teh lulz in "Marvel What The": Galactus vs. The Atom!
Galactus (bored swat): Who?
In Archie Comics' Sonic the Hedgehog, the fight between Sonic and Eggman's Egg Beater was devastating - all Sonic could do was dent the shield the robot was using while Eggman crushed the speedster.
The Transformers Megaseries has Roller (the little vehicle that lives in Optimus Prime's trailer) versus Blitzwing, a heavily armored Triple-Changer. Roller manages to snipe Blitzwing in one shot.
Earlier than that, Shockwave's fight against the Dynobots, once ol' One-Eye gets angry. He takes all five of them out in a few seconds, and wins the fight. He just didn't expect Grimlock to anticipate this, resulting in all five 'bots getting buried for the next several thousand years.