The main protagonist of the series, Spencer is a clever, inventive 14 year old kid who aspires to one day become a famous movie producer. Until that day, however, he makes B-List horror movies with his friends. Though he often gets into trouble due to his and Billy's antics, this also helps him mature as a person.
Master of Illusion: More often with the help of Billy, he gets to have very impressive "special effects" on his movies; though he does manage to make a headless illusion by himself on a school talent show.
Straight Man: He frequently has to play the role in response to Billy's antics
Billy Joe Cobra
Voiced by: Darren Foreman
The supporting protagonist of the series, Billy was once a superstar musician who rocked the charts with his hits...before dying an untimely death and becoming a ghost. Since then he haunts his former mansion, and once he develops a friendship with his distant cousins Spencer, he takes it upon himself to teach how to fit in to the glamorous California lifestyle...which he will repeatedly mess up for various reasons. He is hyperactive, a bit of diva, and has an ego so large it could dwarf a small planet.
Spencer's dad. He can be a bit eccentric but is a very caring father. He works as an accountant but has a passion for inventing and tinkering with things. Ironically, he is terrible with technology (especially computers).
Spencer's mom. She can be a little eccentric but is normally more level-headed than Spencer's dad. She also loves to style hair. Billy Joe Cobra's distant-cousin relationship to the Wrights has been implied to come from her side of the family.
Spencer's little sister. She is very athletic and even has a black belt in karate (which appears to be her favorite sport). She can be a bit annoying at times, and believes her brother is very weird for "talking to himself".
A mysterious woman who not only is aware of the mechanism that it makes Billy visible to human eyes; but is also seeking to catch the ghost, and keep keep him in a jar as part of her extend collection of Billy Joe Cobra memorabillia
A mysterious older man working for Madame X who's tasked with the job of capturing Billy Joe Cobra and returning him to his mistress. Due to Madame X he also knows the secret to see Billy, and wears his underwear to do so. He's a bit bumbling, and messes up most of his successful captures, but he tries.
Butt Monkey: He always manages to fail to capture Billy, and usually ends up being abused by the end.
Bumbling Sidekick: To Madame X. He is constantly messing up in his attempts to capture Billy, which tries her patience.
The principal of Spencer's high school, he is a militant man who hates Spencer with a passion and takes pleasure out of making his life miserable. He will do anything to get him expelled from school, even if he's being unfair and unreasonable in the process.
The star athlete of Spencer's school, Kleet also hates Spencer with a burning passion, and will do whatever it takes to make his life miserable. Thick-headed and driven by anger, he's sometimes The Dragon to Principal Ponsey.
A rich, spoiled, popular girl with a stereotypical valley girl accent. She doesn't like Spencer or his friends, as they usually stand up to her conceited and 'popular' attitude or just plain annoy her (mostly via Spencer's horror movies or Rajeev's flirting).
Tsundere: It's implied that she feels this way towards Rajeev (and Spencer).
Spencer's best friend and lead actor, Rajeev is likable, funny character who helps out Spencer with his movies by playing the lead actor. He can see Billy Joe Cobra by wearing a belt that once belonged to him.
Wholesome Crossdresser: Played with from due to Spencer not having able to afford actual girls appear in his films up to in that one time, tried to be Spencer's date for an award show (long story).
Spencer's friend and Rajeev's sister. She is much more level-headed than her brother and is often the voice of common sense between the two. She wears a pink bracelet that used to belong to Billy in order to see the him. She also has a secret crush on Spencer.