Jessie Rabbeau, who was lost three most important people in her life, the first being Mary, her mother. As explained in the Tear Jerking Chapter 10, her husband Ron was killed during the War only weeks after being married. She found herself to be pregnant afterwards and have a son Sunny, only for him to be murderedhours after being born. No wonder she's a habitual smoker.
Leaf the Tanuki witnessed the mass extermination of his species by Impress, including his parents, and went homeless for a while after nearly evading Impress's forces, before moving to Super City and being forced to work with Impress, who wiped out his species in the first place.
