- Ascended Fanon: The episode brings up the long-standing fan debate that Janeway essentially murdered Tuvix, with several characters being horrified by her actions.
- The Other Darrin: Michael McKean, Martin Rayner, and Fintan McKeown do not reprise their roles as the Clown, Chaotica, or Michael Sullivan for this episode. Instead, James Sie takes over as Chaotica (while a pair of unidentified voice-actors take over the other two roles).
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