What Could Have Been: In 2015, a new Blade ongoing was announced as part of the All-New, All-Different Marvel relaunch, to be written by Tim Seeley (Hack/Slash, Grayson) and drawn by Logan Faerber, and would have featured Blade's daughter. It was cancelled when Seeley left the project, feeling that it would be yet another series featuring a Black lead written with a White creative team.
Snipes described Deacon Frost as the kind of guy who'd iceskate uphill. Stephen Norrington and David S. Goyer loved the phrase so much that they worked it into the dialogue.
California Doubling: Set in New Orleans (according to the script) but shot in Vancouver and Los Angeles.
Deleted Role: Stan Lee originally had a cameo that was ultimately cut from the film. He played one of the cops that come in to the blood club during the aftermath and discover Quinn's body on fire.
Edited for Syndication: When shown on broadcast TV, the scenes of the panty-flashing Japanese schoolgirls in the club is often cut or altered to hide them.
Focus Group Ending: The original ending had Deacon Frost turn into an Eldritch Abomination made from blood but the test audiences found him hard to relate to and they couldn't get the special effects right.
Follow the Leader: In a sense, the movie led to the boom of Marvel Comics-based movies. Though later overshadowed by the 2000's more successful X-Men and Spider-Man, Blade was the first Marvel movie to be a bona fide financial and critical success (Men in Black came out first but technically, it was more a property bought by Marvel than made by Marvel). And granted, some productions such as the aforementioned Spider-Manhad long been gestating, but the movie's success proved that Marvel characters could headline their own movies. Additionally, Blade himself was not as well-known prior to the movie's release, but still made for a successful property. In addition to their A-list stars, Marvel and DC have subsequently looked at other lesser-known characters for possible movies.
Of course, the general public probably wasn't really aware that Blade was a comic book character originally, and thought it was just a cool Vampire Hunter, especially since Buffy the Vampire Slayer premiered a year before.
Though on the flip side, it was thanks to cartoon, Spider-Man: The Animated Series where Blade made his first animated appearance and was still playing at the time, that likewise go interest up among cartoon goers.
Hostility on the Set: According to Wesley Snipes and Stephen Dorff on the DVD Commentary, there was a slight clash between them while filming the hostage scene where Blade and Frost first meet in person. It was Dorff's first day, and while he was trying to establish Frost's motivation, approach, etc. Snipes became impatient and tried to counsel Dorff. Dorff became incredibly frustrated and said he felt overwhelmed since David Fincher and other notable filmmakers visited during filming and added further tension to the frantic on-set nature, forcing Snipes to assert his producer authority and make decisions. Snipes would tell Dorff that it was essential to trust in him, not only as the starring lead but also as producer. Snipes goes on in the commentary to say: "For a while...there wasn't that trust."
The original plan would have had Blade failing to save the world and battling a vampire apocalypse in the sequel. The third film would then be based on I Am Legend.
When Karen Jensen wakes up at Blade's hideout after her attack and rescue by Blade, the script had her discover a jar with a vampire baby in it. The baby would be alive and used by Blade and Whistler as a guinea pig for testing out weapons to fight vampires. The studio however found the concept to be disturbing and refused to allow it.
The scene where Karen and Deacon are talking about the cure for vampirism initially ran a bit longer and answered the question of how the vampires would feed if everybody was turned into a vampire. They would keep some humans alive in giant blood bags to harvest them. The bags can still be seen in a doorway during the scene, and later played an integral part of the plot in Blade: Trinity.
The Prodigy were approached to do the score and soundtrack for the film, but they turned down the offer due to other work commitments
Michael Morbius was planned to be used as the main antagonist in a eventual sequel, but the idea was dropped out due to the fact the character's rights belong to Spider-Man universe, and their movie license were property of Sony at the time. The vampire at the rooftop in the alternate ending of the movie is Morbius.
Pearl was originally designed as an androgynous Japanese man.
Quinn originally had a much smaller role, but Donal Logue was so funny onset that his character was expanded and he was allowed to ad-lib a good portion of his dialogue.
Word of God: According to Stephen Norrington, the cause of Pearl's obese size was the creature gaining a cannibalistic lust for infants and children as he loves to eat their hearts.