Bernadette and Penny go to a pharmaceutical convention, where Penny is offered a job by the competition. Meanwhile, while Howard watches the kids, the gang perform kid experiments from a book Sheldon found.
- Guinea Pig Family: Sheldon brings a book of science experiments to perform on babies (more like games to test the baby's cognition and motor skills) so they could try them out on Howard's kids. This reminds Leonard of the way his mother did psychological experiments on him, and he calls her about it. Beverly reveals that the experiments are still ongoing. (The book, by the way, was Amy's way of getting Sheldon interested in having children.)