The aftermath of last episode's reveal that crash bus victim "John Doe" is O'Malley. All efforts to save him failed, and he is declared brain dead. His mother asks Torres to decide whether to donate his organs.
- An Arm and a Leg: The victim of a speedboat accident arrives to the hospital with both arms AND a leg amputated. Sloan tells her that the former can be reattached.
- Dissonant Laughter: At George's funeral, Karev, Izzie, Meredith, and Cristina are laughing, a sign that they are not dealing OK with their friend's death.
- Five Stages of Grief: In the episode's opening voiceover Meredith explains the Kubler-Ross model.
