Note: The following rules apply to a Normal Run or a Custom Run with achievements enabled.
General
- Drink whenever you gracefully dive into a bed of spikes.
- Drink if you trade blows with an enemy and kill it, and you couldn't rally the lost HP there are no enemies around.
- Drink if you failed a parry because the enemy was Slowed or hitstunned and it threw off your timing.
- Drink if you took damage while you were stunned from falling too high.
- Drink for every 2 stages you go without finding a single Secret Tile.
- Drink if you died while holding a rare blueprint, and you didn't use Hunter's Grenade to drop it.
- Drink if you lose more than 150 Cells (unless you unlocked everything).
- Drink if an item you found in a Chest is the same as something you already have and it's worse.
- Drink if you find a lower quality item when you have at least 90% chance on finding the highest quality item.
- Drink if you find a Legendary item before the first boss.
- Drink twice if you find a Legendary item that's a base you disabled in Custom Run.
- From third stage onwards, drink for every 3 Pendants you find that doesn't have any of your primary stat.
- Drink if you find food in a lore room.
- Cursed Chest:
- Drink if you found a Cursed Chest when most of the enemies were dead.
- Drink if you enter the next area while cursed. Drink again if you go into a boss room.
- Drink if a Cursed Chest spawned in Prisoner's Quarters. (1% chance!)
- Take a shot if a Cursed Chest drops a colorless Cursed Sword.
- Take a shot if you are a coward and didn't open the Cursed Chest in Prison Depths or Corrupted Prison, the entire reason for entering these biomes.
- Drink if you died from the curse (not from Cursed Sword). Take a shot instead if the curse was from food you ate while you had Acceptance.
- Drink if you died while holding a Cursed Sword. Drink again if it was in your backpack.
- Take a shot if you break a Golden Door by accident.
- Drink if you find a Corrupted Artifact. Take another drink if you don't pick it up it.
- Take a celebratory shot if a Fragment of the Philosopher's Stone drops.
- Take a shot if you died inside a Challenge Rift.
- Drink for every 3 stages you go without replacing any equipped item (not including backpack).
- Drink if you find/roll an item with at least 3 different "fires an arrow/bomb" mods.
- Drink if you find/roll an item with a Quad Damage mod... and you take it.
- Drink once per stage if Malaise reaches at least 70%.
- Drink if beating a boss didn't fully clear your Malaise gauge.
- Drink 4 times when Ygdar Orus Li Ox triggers. Reduce by 1 for each boss you've defeated.
- Drink if you find a large food while you have Dead Inside.
- Drink if Masochism actually prevented you from dying.
- Take a shot if you somehow died while Disengagement was off cooldown.
Stages
- Prisoner's Quarters:
- Drink if the last room you searched before proccing Explorer's Rune was the Hunter's Grenade room.
- Toxic Sewers/Ancient Sewers:
- Drink if you lose a 30+ kill streak because you stepped in toxic sewer water.
- Morass of the Banished:
- Drink if you sacrificed the Mushroom Boi.
- Slumbering Sanctuary:
- Drink if you failed the Emergency Door challenge.
- Fractured Shrines:
- Drink if an enemy or trap knocks you off into a pit.
- Drink if you aggro'd the Stone Warden that wasn't guarding a door.
- Forgotten Sepulcher:
- Drink if you lost more than 25% of your health at once from the darkness.
- Drink if you bought the Night Light.
- Undying Shores:
- Take a shot if you guessed the correct Rune door containing the Cocoon blueprint correctly.
- Derelict Distillery:
- Drink if you got hit by a barrel that an enemy reflected. This also applies to the Barrel Launcher in any stage.
- Drink if the very last dead end you search contains the Distillery Key.
- The Bank:
- Take a sip for every 2000 Gold you borrow (even if you pay it back). Convert it to a shot for every 10000 Gold instead.
- Take another sip for every 2000 Gold you don't pay back at the end of the stage. Same sip-to-shot conversion applies.
Enemies
- Arbiter: Drink if you took damage from its posthumous bomb.
- Apostate: Drink if you got hit by something because its wall projection got in the way.
- Automaton: Drink if you were hit by the same Automaton that teleported away. Drink again if it spawned from Malaise.
- Cannibal: Drink if you got hit by a bomb that it dropped right before it died.
- Caster: Drink if it hits you with its fireball, then teleports away before you could hit it back.
- Catcher: Drink if you get caught by its grappling hook and you couldn't roll out of the swipe attack on time.
- Cleaver: Take a shot if its axe gets caught in a wall and it hits you way more times than it normally would.
- Corpse Juice: Drink if you get hit by one.
- Dark Tracker: Take a shot if you get hit by its extremely slow, extremely telegraphed backstab attack.
- Demolisher: Drink if you got hit by crossbow melee attack while you were behind it.
- Golem: Drink if you accidentally aggro one without meaning to.
- Lacerator: Take a shot if a single spin decimated more than half your health.
- Gold Gorger: Drink when you have to fight a fully transformed Gold Gorger.
- Guardian Knight: Take a shot if you got hit by its incredibly slow overhead swing.
- Lancer: Drink if you get hit by one while on a ladder.
- Librarian: Drink if you couldn't kill it before it repeats its attack pattern.
- Living Barrel: Drink if 3 of more of these are chasing you at the same time.
- Oven Knight: Drink if you got hit by its shield bash and then you get hit by other enemies while you were stunned.
- Pirate Captain: Drink if you get hit by the cannonball's explosion without actually getting hit by the cannonball.
- Protector: Drink if its shield completely blocks all damage from a cooldown skill.
- Rampager: Take a shot if you get hit by all four of its claw swipe attack.
- Royal Guard: Drink if you have to find one in a narrow hallway with no nearby platforms.
- Shieldbearer: Drink if got hit by anything while you were hitstunned from hitting its shield.
- Slammer: Drink if you get hit by its ground slam attack twice in a row... after you rolled behind the first one.
- Slasher: Drink if you couldn't stun it before it hits you with its wave attack on the third slash.
- Skeleton: Drink if you get hit by one while it was Rooted or Stunned (which it is immune to).
- Thorny: Drink if you hit its back with a melee weapon and you take damage.
- Undead Archer: Drink if you actually managed to get hit by one of its arrows.
- Elites (in general):
- Drink if you get hit by the square "electric cage".
- Drink it respawns its crystal force field... twice.
- Drink if you get hit by an Elite while it was invisible.
- Drink twice if a double Elite does a team combo on you.
Bosses
- The Concierge:
- Drink if you get hit by its Lacerating Aura after rolling behind it.
- Conjuntivius:
- Drink if the summoned tentacles dealt more damage to you than Conjuntivius did.
- Drink if it used its "bullet hell" attack more than once.
- Mama Tick:
- Drink if you got hit more than once by its rapid tentacle impale attack. Drink again if it was the only attack you got hit by.
- Time Keeper:
- Drink if you got hit by her shurikens 4 or more times in a row.
- Drink if you get hit by the falling swords.
- The Giant:
- Drink if the Giant uses both his super-charged fist attacks.
- Drink if you get hit by a falling stalagmite while his eye was exposed and knocks you off his hand.
- Drink if you get somehow manage to escape his laser eye prison, but get hit by his hand bullets anyway (Tip: use Assault Shield).
- The Scarecrow:
- Drink if you got hit airborne after bouncing off a mushroom.
- Drink if you got hit right after a Jerkshroom hit you.
- Drink if the Scarecrow uses his scythe throw move really close to the ground.
- Drink if you took several hits from the watering can move.
- The Hand of the King:
- Drink if you took damage from the enemies that the Hand of the King summons.
- Drink twice if you get hit by the banner explosion.
- Drink every other time you get hit by That One Move where it does an extremely quick stab before the Telluric Slam.
- The Servants:
- Drink if you take fall damage while climbing the Lighthouse.
- Drink if you get combo'd for more than half your health by multiple Servants.
- Drink if you have enter the fight with no way to deal with Kleio's spinning attack (no shield, ranged attacks, etc.).
- The Queen:
- Drink if you trigger her enrage mechanic.
- Take a shot if you died without the Queen giving you a second chance.
- Take a shot if you took less damage overall from the Queen boss fight than the Servants.
- The Collector:
- Drink if you took damage during the phase where enemies are summoned.
- Drink whenever you take damage from any stage hazard.
- Drink the whole bottle if you grabbed the Panacea but died before you could drink it.
