History YMMV / OsmosisJones

-Except that movie takes place in the human psyche and not the human body. But the premises are indeed quite similar.

* AudienceAlienatingPremise: For once, it was this and not a lack of advertisement on WB's part that caused the film to flop. The film couldn't mesh the live-action gross out comedy with the animated buddy-cop with each portion only detracting from each other. Though given the success of [[WesternAnimation/InsideOut another film that shows the inner workings of the human body]], one might wonder that it was ahead of its time.

* AudienceAlienatingPremise: For once, it was this and not a lack of advertisement on WB's part that caused the film to flop. Though given the success of [[WesternAnimation/InsideOut another film that shows the inner workings of the human body]], one might wonder that it was ahead of its time.

** Frank eating food while trying to have a moment with his daughter about their mom passing away is such a pathetic sight that you can't help but laugh at it.

* {{Narm}}: Uncle Bob's reaction to [[spoiler: Frank getting hospitalized]]. His "crying" honestly sounds like hooting laughter.

* CompleteMonster: Thrax is a disturbing personification of a human virus. Obsessed with fame and breaking records in the medical books, to this end, Thrax infiltrates humans and sees how fast he can murder them. Upon arriving in the human Frank, in whose body most of the film takes place, Thrax sets about gruesomely murdering whoever crosses his path, while making Frank sicker and sicker. This has the benefit of killing not only Frank, but every being living within him. When his remaining henchmen suggest that they incubate, Thrax kills them and sets off to kill Frank on his own. Thrax even threatens the titular protagonist, Osmosis Jones, that after Frank is dead, Thrax will gladly go and [[WouldHurtAChild break his new record on Frank's young daughter.]]

* CompleteMonster: Thrax is a disturbing personification of a human virus. Obsessed with fame and breaking records in the medical books. To this end, Thrax infiltrates humans and sees how fast he can murder them. Upon arriving in the human Frank, in whose body most of the film takes place, Thrax sets about gruesomely murdering whoever crosses his path, while making Frank sicker and sicker. This has the benefit of killing not only Frank, but every being living within him. When his remaining henchmen suggest that they incubate, Thrax kills them and sets off to kill Frank on his own. Thrax even threatens the titular protagonist, Osmosis Jones, that after Frank is dead, Thrax will gladly go and [[WouldHurtAChild break his new record on Frank's young daughter.]]

* NauseaFuel: Most of the movie, especially the scene with the zit.

* MoralEventHorizon: Thrax horribly murders two cells in his introduction with his touch. If that's not enough, he reveals a collection of DNA from past victims. One of them was [[WouldHurtAChild a little girl who didn't want to wash her hands.]]

* CompleteMonster: Thrax, a sinister virus obsessed with fame and breaking records in the medical books. To this end, Thrax infiltrates humans and sees how fast he can murder them. Upon arriving in the human Frank, in whose body most of the film takes place, Thrax sets about gruesomely murdering whoever crosses his path, while making Frank sicker and sicker. This has the benefit of killing not only Frank, but every being living within him. When his remaining henchmen suggest that they incubate, Thrax kills them and sets off to kill Frank on his own. Thrax even threatens the titular protagonist, Osmosis Jones, that after Frank is dead, Thrax will gladly go and [[WouldHurtAChild break his new record on Frank's young daughter.]]

* AudienceAlienatingPremise: For once, it was this and not a lack of advertisement on WB's part that caused the film to flop.

** The movie showing the workings of the human body as a whole, including dreams, became this when Disney/Pixar's ''WesternAnimation/InsideOut'' premiered in 2015.

** The movie showing the workings of the human body as a whole, including dreams, became this when Disney/Pixar's ''WesternAnimation/InsideOut'' premiered in 2015, something WebVideo/TheNostalgiaCritic picked up on when he reviewed ''Jones'' weeks after Pixar's movie hit theaters.

---> '''TheNostalgiaCritic:''' ''Osmosis Jones''! A ''family'' picture! That's gonna haunt the shit out of me!

* CompleteMonster: Thrax, a sinister virus obsessed with fame and breaking records in the medical books. To this end, Thrax infiltrates humans and sees how fast he can murder them. Upon arriving in the human Frank, in whose body most of the film takes place, Thrax sets about gruesomely murdering whoever crosses his path, while making Frank sicker and sicker. This has the benefit of killing not only Frank, but every being living within him. When his remaining henchmen suggest that they incubate, Thrax kills them and sets off to kill Frank on his own. Thrax even threatens the titular protagonist, Osmosis Jones, that after Frank is dead, Thrax will gladly go and [[WouldHurtAChild break his new record on Frank's young daughter.]]

--> '''TheNostalgiaCritic:''' ''Osmosis Jones''! A ''family'' picture! That's gonna haunt the shit out of me!

* CompleteMonster: Thrax, a sinister virus obsessed with fame and breaking records in the medical books. To this end, Thrax infiltrates humans and sees how fast he can murder them. Upon arriving in the human Frank, in whose body most of the film takes place, Thrax sets about gruesomely murdering whoever crosses his path, while making Frank sicker and sicker. This has the benefit of killing not only Frank, but every being living within him. Thrax even threatens the titular protagonist, Osmosis Jones, that after Frank is dead, Thrax will gladly go and [[WouldHurtAChild break his new record on Frank's young daughter.]]

** Thrax's name sounds similar to Anthrax. This film was released mere ''months'' before the September 11 Anthrax attacks.

** Thrax declaring that "Ebola is a case of ''dandruff'' compared to me!" is made somewhat funnier by the arrival of ZMapp, Ebola's highly tentative cure. Could also be FunnyAneurysmMoment after the Ebola 2014 break out.

*** [[spoiler:Not that he didn't deserve it, but Thrax [[FamilyUnfriendlyDeath finds out the hard way that alchohol is like sulfuric acid to germs]]. ''Ouch.'']]

** Frank picks up a hardboiled egg and eats it. What makes this Squick? The egg has been on the ground in a filthy chimpanzee cage, and before that it was IN THE CHIMP'S MOUTH. Maybe all his unhealthy habits were affecting his brain?

*** [[spoiler:Not that he didn't deserve it, but Thrax finds out the hard way that alchohol is like sulfuric acid to germs. ''Ouch.'']]

** One of his first victims was a little girl who didn't like to wash her hands.