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* [[http://www.scp-wiki.net/clef101 There's an article]] on the ''Wiki/SCPFoundation'' where Dr. Clef says that the best way to kill a RealityWarper is to shoot them through the head before they know you're there.

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** A deleted scene in season 2 has Sylar trying to kill an indestructible man and steal his powers. The only way he can manage to do it is to telekinetically pull his brain out through his nose and the roof of his mouth.

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* ''Literature/Area51'': This turns out to be the only way the Airlia can be killed, since their technology heals anything else.

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* Cell from ''Anime/DragonBallZ'' was the TropeNamer for regenerating FromASingleCell. As long as a group of core cells in his brain are intact, he can regenerate the rest of his body. He was also shown regrowing his head at one point, so the English dub said he can regrow his body from any cell.

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* In one episode of ''WesternAnimation/TheClevelandShow'', Cleveland Jr. acknowledges that he'll have to do one of these in the event that his birth mother Loretta comes back as a zombie.


* The Ctarl Ctarl from ''Anime/OutlawStar'' are NighInvulnerable and one of the few ways to kill them is to crush their skulls.



* The Ctarl Ctarl from ''Anime/OutlawStar'' are NighInvulnerable and one of the few ways to kill them is to crush their skulls.

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* The Ctarl Ctarl from ''Anime/OutlawStar'' are NighInvulnerable and one of the few ways to kill them is to crush their skulls.




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* The Ctarl Ctarl from ''Anime/OutlawStar'' are NighInvulnerable and one of the few ways to kill them is to crush their skulls.

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* In ''Series/IZombie'', destroying the brain is just about the only way zombies can be killed.

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* Shooting It through the head seems to be the only way to stop the monster from ''Film/ItFollows''. Though WordOfGod says it survived.


The ubiquitous "gotta shoot 'em in the head" scenario. For many different reasons, TheUndead throughout fiction are vulnerable only to BoomHeadshot. Kinda like how ([[OurVampiresAreDifferent many]]) vampires are only vulnerable to getting stabbed in the heart. Fortunately, removal of the head also works on people who are not a member of the walking dead, so you don't have to worry about it going out of fashion as a killing method. This may have a somewhat scientific basis: first, a zombie would have a lowered to nonexistent pain response, and would most likely not stop attacking until its nervous system has been effectively severed since it is ''dead'', pettier issues like "missing organs" or "blood loss" won't be as effective as they would be on the living. Second, mindless though they may seem, zombies logically have to still need brains to command to their muscles to walk, to analyze what their eyes send them and thus know that there is a human to be eaten in front of them, etcetera.

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The ubiquitous "gotta shoot 'em in the head" scenario. For many different reasons, TheUndead throughout fiction are vulnerable only to BoomHeadshot. Kinda like how ([[OurVampiresAreDifferent many]]) vampires are only vulnerable to getting stabbed in the heart. Fortunately, removal of the head also works on people who are not a member of the walking dead, so you don't have to worry about it going out of fashion as a killing method. This may have a somewhat scientific basis: first, [[YouCantKillWhatsAlreadyDead a zombie would have a lowered to nonexistent pain response, and would most likely not stop attacking until its nervous system has been effectively severed severed]] since it is ''dead'', pettier issues like "missing organs" or "blood loss" won't be as effective as they would be on the living. Second, mindless though they may seem, zombies logically have to still need brains to command to their muscles to walk, to analyze what their eyes send them and thus know that there is a human to be eaten in front of them, etcetera.

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** Subverted in the second and third games' multiplayer modes. Zombie characters have the unique ability to continue fighting without their heads if they still have health remaining, and lose their head after a single headshot from any weapon. Headshotting a zombie character with a low powered weapon on multiplayer can make them ''tougher'' to kill.


* ''Literature/TheStormlightArchive:'' In a rare non-undead example, a [[ThePaladin Knight Radiant]] can only be killed by a blow to the head. Anything else, up to and including being stabbed through the heart or having [[AnatomyOfTheSoul part of their soul cut off]], they can recover from with sufficient [[Mana Stormlight]].

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* ''Literature/TheStormlightArchive:'' In a rare non-undead example, a [[ThePaladin Knight Radiant]] can only be killed by a blow to the head. Anything else, up to and including being stabbed through the heart or having [[AnatomyOfTheSoul part of their soul cut off]], they can recover from with sufficient [[Mana [[{{Mana}} Stormlight]].

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* ''Literature/TheStormlightArchive:'' In a rare non-undead example, a [[ThePaladin Knight Radiant]] can only be killed by a blow to the head. Anything else, up to and including being stabbed through the heart or having [[AnatomyOfTheSoul part of their soul cut off]], they can recover from with sufficient [[Mana Stormlight]].

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* Episode 2 of ''WebVideo/MissingReel'', [[ExcitedShowTitle "Zombies!"]], since it emphasizes how ''Film/NightOfTheLivingDead1968'' established the "aim for the head" method of killing zombies.


* Zigzagged in ''VideoGame/PlagueInc''. Necroa cannot reanimate headless corpses until you evolve Cranial Metastasis; which causes brain tissue to develop in the chest cavity. Another symptom causes the skull to thicken, making it harder for survivors and Z Com/ Black Water soldiers to kill them by headshot.

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* Zigzagged in ''VideoGame/PlagueInc''. Necroa cannot reanimate headless corpses until you evolve Cranial Metastasis; which causes brain tissue to develop in the chest cavity. Another symptom causes the skull to thicken, making it harder for survivors and Z Com/ Black Water Z-Com/ Blackwater soldiers to kill them by headshot.

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