History Main / MasterPoisoner

* ''Literature/TheMalloreon'': First introduced as a reluctant antagonist in the ''Literature/{{Belgariad}}'', Sadi is shown to be exemplary even by Nyissan standards especially after becoming a protagonist. He has an encyclopaedic knowledge of, and incredible skill at, pharmacology, drug-dealing, and anything related to potions and chemicals in general. He is creative, clever and wily, able to weaponise almost any chemical concoction, favouring PoisonedWeapons, and is a rare fictional example of a truly badass eunuch. Garion's page quote is NotHyperbole, as Sadi eventually proves through some excellent people-watching skills and a poisoned spoon.

** Professional hitman Somg specializes on poisoning people. He is obsessed with a quality of his poisons and makes all of them himself, in his own laboratory. On top of regular posions he is able to create deadly artificial viruses and can tailor their effects for various situations - [[spoiler:like virus, that makes target appear seriously sick, but becomes inactive after a few hours, leaving only minor damage.]] His talents works even beyond the poisons - for example he create higly effective nutrients.

* Assassin of Red, a.k.a Semiramis, of ''LightNovel/FateApocrypha''. Her Noble Phantasm, Sikera Ušum: Arrogant King's Alcohol, allows her to create a plethora of terrifyingly deadly poisons while inside her fortress. This includes being able to give her magecraft or even the air itself poison attribute, have her poison be composed of such things as Hydra venom and even summon poisonous beasts such as the Basmu from Mesopotamian mythology. This is actually why she's summoned as an Assassin and not a Caster. [[SquareRaceRoundClass Despite having the powers and skill set for the mage class]], her legend of being the first poisoner is more famous, so she is placed in the class of illusive killers.

* [[spoiler:Mathilda Toulonchamp]] from ''Manga/HonooNoAlpenRose'' may be too young to called a full-fledged master poisoner, but she still manages [[spoiler:to use it to slowly poison Helene to make her ill,]] and it's heavily implied that [[spoiler:she tries to do the same thing to Jeudi aka Helene's daughter Alicia by poisoning her food, but she doesn't get the job done.]]
* In ''Manga/InuYasha'' there are several, including Sango, Yakorou Dokusen and Mukotsu from the Band of Seven who almost succeeded [[spoiler: in killing half the titular character's team]].

* In ''Manga/{{Kurokochi}}'', Susanoo's Cherry Tree has been secretly perfecting chemical weapons and poisons for decades after the end of the war. Their latest product is a timed poison which becomes lethal only when the target ingests two innocuous drinks, which works even at an one hour interval and thus making the culprit untraceable.

** Sasori. All his weapons are equipped with a very special poison he created himself which makes the victim suffer extreme pain for three days before dying, if he decided not to finish the victim off in the first place.

* Coco from ''Manga/{{Toriko}}'' not only able to [[PoisonousPerson create and secrete various poisons in his own body]] - he also expert in all kinds of poisons, which is suitable, since his enemies often has immunity and he has to get crafty to kill them. Not only he can create poisons with various effects, from ones that paralyse targets to ones that make their flesh melt away, he also developed virus poison, which can adapt to immune systems of the target and strike down foes, who normally would be immune to it. He is so skilled, that he can poison even ''robots'' - by using gases, which turn into highly corrosive acid on certain metals. Surprisingly, he [[BadPowersGoodPeople is the most nice person out of Four Kings]].

* ''WesternAnimation/AvatarTheLastAirbender'': In the sequel comic ''ComicBook/AvatarTheLastAirbenderTheSearch'', none other than [[spoiler: Prince Zuko's mother, Ursa, is revealed to be this. She knew how to make an odorless, color-less, lethal poison that was next to impossible to detect. She ended up offering a deal to Ozai; she would concoct the poison and give it to him to do as he pleased (the idea being he'd poison his father and then take the throne) and Zuko (who was going to be executed as a punishment to Ozai) would be spared. Ozai accepts.]]

* ''ComicBook/MouseGuard'': [[spoiler:Abigail]] in the Winter arc. She sabotages Lockhaven's food stores, nearly kills Rand, and attempts to poison the well.

* ''Comicbook/RedRobin'': Funnel of the Council of Spiders takes pride in creating quick acting incredibly painful poisons, and is insulted by other poison using murderers whose poisons don't fit what she thinks a perfect poison should be or are "boring".

** Vetinari is also rumored to have studied poisons at the Guild and be an expert on them (and according to the ''Assassins' Guild Diary'' he has the Guild degrees to indicate this) but like Downey he has no confirmed poisoning victims. Not even when [[Literature/MakingMoney Moist von Lipwig thinks he does]].

* ''Literature/TheMalloreon'': First introduced as a reluctant antagonist in the ''Literature/{{Belgariad}}'', Sadi is shown to be exemplary even by Nyissan standards especially after becoming a protagonist. He has an encyclopaedic knowledge of, and incredible skill at, pharmacology, drug-dealing and anything related to potions and chemicals in general. He is creative, clever and wily, able to weaponise almost any chemical concoction, favouring PoisonedWeapons, and is a rare fictional example of a truly badass eunuch. Garion's page quote is NotHyperbole, as Sadi eventually proves through some excellent people-watching skills and a poisoned spoon.

** The Faceless Men are professionally trained assassins who naturally use a wide range of drugs, toxins and poisons as a part of their arsenal, many with possibly magical ingredients. They specialize in MakeItLookLikeAnAccident-type assassinations.
** Oberyn Martell is well known to use complex poisons: it even helps supply his moniker of "[[NamesToRunAwayFromReallyFast The Red Viper]]"... and Tyene, one of his bastard daughters collectively called the Sand Snakes, takes after Daddy, as well. When she briefly touches her uncle's hand after an argument, Prince Doran's maester hurries over to inspect his hand for puncture marks, and expresses concern over poisons that can be absorbed through the skin.

* ''Series/DeadMansGun'': Lillian/Tanya in "Black Widow". She murders her first husband by injecting poison into the bottle through the cork; concots a poison that she siaks into the cloth cage cover and drapes over the lovebirds' cage to kill them; and kills [[spoiler:Stanford]] by serving him a toxic mushroom that is completely harmless, unless consumed with wine.

* The villain of the pilot of ''Series/{{Forever}}'', a former chemist who uses aconite, a near instant and incredibly painful poison from the monkshood flower, and who is planning to use it in gas form to distribute through Grand Central Station as revenge on the train companies who were "responsible" for his wife's death on a subway track.

** Littlefinger turns out to be one. Not only does he work with Olenna Tyrell to have King Joffrey poisoned during a lavish banquet, it's later revealed that he had Lysa Arryn poision her husband Jon Arryn, kicking off the War of Five Kings storyline.

* Locusta's in Music/{{Macabre}}'s "Locusta" is portrayed as a PsychoForHire who’s method of killing was poisoning.

* In the ''D&D'' lawyer-friendly spinoff ''TabletopGame/{{Pathfinder}}'', a number of classes such as rogues, assassins and the currently experimental ninjas are proficient poisoners, but it's the [[TheRedMage Alchemist]], which can not only make poisons, but becomes completely immune to them, can refine them into a more deadly, harder to resist form, make them last longer on the weapon and make them in a fraction of the time with reduced material costs.

* Alfyn Greengrass from ''VideoGame/OctopathTraveler'' is primarily a [[TheMedic healer]] who just wants to help people, but is certainly capable of using his knowledge as an apothecary to inflict harm when needed. One of his class skills, Empoison, always succeeds if the target is vulnerable to poison--and the vast majority of enemies, including most chapter bosses and ''several of the setting's gods'', are. He can also mix items to Concoct harmful powders that have a chance of inflicting various StandardStatusEffects, including poison, to the whole enemy team. In story, he carries a plant called ''slumberthorn'' whose toxin not only pulls the victim into a deep sleep, but [[spoiler: plagues the victim with horrifying nightmares if they have any evil deeds weighing on their conscience. He uses this to subdue and partially reform the Chapter 2 boss after their battle.]]

* ''VideoGame/SakuraDungeon'': Slimes use poison skills quite a lot and they're quite useful because of it. Noblewomen later in the game also almost exclusively use them. In fact they possess almost every possible poison skill in the game.
* The Silent from ''VideoGame/SlayTheSpire'' has this as her modus operandi, if she isn't [[KnifeNut shivving her enemies to death]]. She can summon poison clouds, use [[Main/PoisonedWeapons poisoned weapons]] or throw flasks with lethal poison. She can even double or triple the poison's effectiveness if her poisons don't work fast enough.

* ''WesternAnimation/BatmanTheAnimatedSeries'': The inevitable showdown between the RoguesGallery's two master poisoners occurred in "Harley and Ivy", when ComicBook/TheJoker came looking for Harley Quinn after she had [[AmbiguouslyGay gone to live with Poison Ivy]]. Joker had his goons grab Ivy and sprayed a mist from his poisonous lapel flower in her face. Ivy was completely immune.

One of [[spoiler:Yau-si]]'s methods of assassination in ''Manga/BananaFish''. He's said to be extremely talented at it, though we don't see him use it often.

* Assassin of Red, a.k.a Semiramis, of ''LightNovel/FateApocrypha''. Her Noble Phantasm, Sikera Ušum: Arrogant King's Alcohol, allows her to create a plethora of terrifyingly deadly poisons while inside her fortress. This includes being able to give her magecraft or even the air itself poison attribute, have her poison be composed of such things as Hydra venom and even summon poisonous beasts such as the Basmu from Mesopotamian mythology.

* This is the speciality of Poison Pete in ''Film/AccidentMan''.

* Sucy of ''Anime/LittleWitchAcademia'' is supposedly a general potions specialist, but all we really see her do is make poisons. And she is ''very'' good at it; in the OVA, one of her concoctions turned it's victim to into [[ImMelting a pile of goo]], which then melted through the solid stone floor!

** Lord Hong, the main villain from ''Discworld/InterestingTimes'', is one as well. At one point, his poison causes a man to ''explode''.
** The Duke of Sto Helit, the main villain of ''Discworld/{{Mort}}'' is known to be this, which is why his cousin the king doses himself with every antidote known to man. He's very surprised when the Duke hires a man to shoot him instead. (Although he gets some satisfaction from learning the Duke provided the assassin with [[YouHaveOutlivedYourUsefulness a packed lunch]].)
** Vetinari is also rumored to have studied poisons at the Guild and be an expert on them (and according to the ''Assassins' Guild Diary'' he has the Guild degrees to indicate this) but like Downey he has no confirmed poisoning victims. Not even when [[Discworld/MakingMoney Moist von Lipwig thinks he does]].

* The villain of the pilot of ''Series/{{Forever}}, a former chemist who uses aconite, a near instant and incredibly painful poison from the monkshood flower, and who is planning to use it in gas form to distribute through Grand Central Station as revenge on the train companies who were "responsible" for his wife's death on a subway track.

* In ''TableropGame/GodsOfTheFall'', Aladurra crafts deadly poisons that often cause additional deleterious side effects (such as intense pain before death).