History Main / GeneticAbomination

* The ''VideoGame/{{Fallout}}'' series has a wide variety of mutated eldritch horrors. There's Centaur, Floaters, Fog Crawlers, Mirelurks, and the unforgettable Master?
** ''VideoGame/Fallout3''’s ''Mothership Zeta'' expansion features a genetically engineered enemy literally called “Abomination” that is the unholy fusion of humans and the Zetan aliens that the DLC revolves around.

* ''TabletopGame/{{GURPS}}'': In keeping with the game's assumption of a realistic baseline, most of the products of imagined future biotechnology in supplements such as ''GURPS Bio-Tech'' are relatively low-key, but a few are abominable, such as the scary "Chronos" genetically engineered warriors or the venomous neo-vampire bat.

* ''Literature/AllTomorrows'': In the distant future, humanity goes to war against the Qu, a race of ScaryDogmaticAliens... and they lose. The Qu punished the survivors by turning them into these. Many of these creations would qualify as WoobieSpecies, such as the [[AndIMustScream Mantelopes]], who were changed into grazing ungulates but retained their human intelligence and sapience -- they cannot talk or do anything in their new bodies but vividly recall their past forms, so they spend their centuries wandering the plains of their world, screaming and singing in despair.

* ''Literature/HorusHeresy'': The positively ''nightmarish'' creations of the self-described "Worker of Obscenity" Basilio Fo. None of them look remotely human and yet it's obvious they were ''made'' from humans.

* A great number of enemies encountered in the ''Franchise/ResidentEvil'' series could certainly count.
** The ''VideoGame/ResidentEvilRemake'' gives us Lisa Trevor, a hunchback with tentacles sticking out of her body, her own face covered in the faces of her victims, and CreepilyLongArms shackled together.
** ''VideoGame/ResidentEvil2'' and its [[VideoGame/ResidentEvil2Remake remake]] give us William Birkin's various forms as his mutation progresses.
** Most of the bosses of ''VideoGame/ResidentEvil4'' embody this trope, from the Verdugos, to the Plaga Queen, the U-3, to Saddler's final form.

-->-- ''[[Franchise/{{Dune}} The Dune Encyclopedia''

''"While their numerous particular actions and products generated significant ill will, it is more likely that the Tleilaxu were generally loathed for a more primordial reason. Their genetic manipulations massed life and nature. The Bene Gesserit could be tolerated, even admired, for their pretension at improving humanity, but Bene Tleilax's distortions only inspired primal horror."''

->''"I escaped from the petri dish... WHAT AM I!?"''
-->-- '''Russell Howard''', ''Series/MockTheWeek'', "Unlikely Things to Hear on a Science Documentary"

* In ''VideoGame/{{Undertale}}'', [[spoiler:the Pacifist epilogue starts by the exploration of the True Lab, a place where Alphys (and possibly Gaster before her) experimented on Determination on monsters, and where the only results are horrible fusions of the UglyCute creatures of the Underground. This includes some weird spoon monster which waits for your character to go into a bed before... covering them and petting their head, another one hiding behind the curtain of a bathtub which disappears right ''when you open it'', and among the ones you fight, the Endogeny may be the most confusing one, as it is a fusion of five different dogs (which are represented in the negative spaces between its six legs), it shakes uncontrollably as the battle progresses, and when it's appeased, the negative spaces [[MindScrew suddenly have happy faces]]]].

* In ''VideoGame/{{Undertale}}'', [[spoiler:the Pacifist epilogue starts by the exploration of the True Lab, a place where Alphys (and possibly Gaster before her) experimented on Determination on monsters, and where the only results are horrible fusions of the UglyCute creatures of the Underground. This includes some weird spoon monster which waits for your character to go into a bed before... covering them and petting their head, another one hiding behind the curtain of a bathtub which disappears right ''when you open it'', and among the ones you fight, the Endogeny may be the most confusing one, as it is a fusion of five different dogs (which are represented in the negative space between its six legs), it shakes uncontrollably as the battle progresses, and when it's appeased, the negative space [[MindScrew suddenly have happy faces]]]].

-->-- '''Russel Howard''', ''Series/MockTheWeek'', "Unlikely Things to Hear on a Science Documentary"

* ''VideoGame/StarcraftII'' has the Hybrids, created by mixing DNA from the [[HigherTechSpecies Protoss]] and the [[HordeOfAlienLocusts Zerg]] in order to serve as servants of and vessels for the rogue [[SufficientlyAdvancedAliens Xel'naga]] [[BigBad Amon]]. The Protoss and [[HordeOfAlienLocusts Zerg]] themselves are both products of earlier rounds of Xel'naga engineering, and the Zerg qualify for this trope themselves.

* Though its occurence is almost never artificial, cancer counts. The name itself strikes fear into those who are diagnosed with it, and though much study have been done to understand it, many still die of it every year.\\

This is a specific subset of the classic EldritchAbomination that is not a naturally-existing being, but was created and cultivated artificially, usually through genetic engineering. That doesn't make them any less horrifying -- and in some cases, it could make them ''more'' so, since they are so different from the natural organisms used in their creation and proves how powerful their creator's capabilities '''''really''''' are. Their resemblance to natural organisms varies. At best, they'll just look like a [[UncannyValley warped version]] of the creatures that they were derived from, putting them in AnimalisticAbomination territory. Other times, though, they'll bear absolutely no resemblance whatsoever to anything that ever evolved naturally.

* ''Literature/{{Frankenstein}}'': Quite possibly the TropeCodifier of this trope, a very large portion of genetic abominations have been influenced by the classic creature himself- Frankenstein's monster. Though his intentions and personality are completely different (he does have an intelligent human mind), his basic concept is still incredibly important.

* Though its occurence is almost never artificial, cancer counts. The name itself strikes fear to those who are diagnosed with it, and though much study have been done to understand it, many still die of it every year.\\

A GeneticAbomination borne of mutations, its physical form is similarly aberrant; malformed tumors and patchwork vessels, unholy fusion of both healthy and rogue cells. It will continue to grow, eventually spreading its invasive tendrils to other organs, choking and killing them, and thus, their host. It is invasive yet evasive, preventing the immune cells from killing it, and able to spread to other loci, seeding new masses of malformed flesh FromASingleCell. Some tumors are even able to differentiate their cells ''just'' enough to grow organs like hair and teeth in random spots, making them particularly grotesque. The fact that its diagnosis often justify HarmfulHealing is testament to its [[TheDreaded dreaded status]]; treatments that will cause ''severe'' damage to healthy cells is considered acceptable trade-off in the attempt to kill this abomination off, and sometimes even that's not enough.