History Main / ChemicallyInducedInsanity

Often this would be maintained by having a caregiver giving the patient "medicine" to treat their mental illness, but in reality is dosing them to keep them insane. May be administered by SlippingAMickey and/or WaterSourceTampering.

* In John D. [=MacDonald=]'s Travis [=McGee=] novel ''Nightmare in Pink'', [=McGee=] has a hallucinatory drug slipped into his drink. When he loses control, he's taken into custody by the bad guys and sent to a mental hospital so he can be interrogated and lobotomized.

* ''WesternAnimation/StarWarsTheCloneWars'': Fives finds out about the chips in the clones that will force them to kill the Jedi when Order 66 is activated. In [[Recap/StarWarsTheCloneWarsS6E4Orders "Orders"]], Nala Se drugs him with something that makes him ultra-paranoid. This, combined with Palpatine telling him the truth about everything, has Fives acting more and more deranged until he is killed by Commander Fox, with no one seeming to believe him. [[spoiler:SequelSeries ''[[WesternAnimation/StarWarsRebels Rebels]]'' reveals that Rex eventually realized he was telling the truth.]]

[[folder:Films -- Live-Action]]

* ''WesternAnimation/StarWarsTheCloneWars'': Fives finds out about the chips in the clones that will force them to kill the Jedi when Order 66 is activated. The Kaminoans drug him with something that makes him ultra paranoid. This combined with Palpatine telling him the truth about everything has Fives acting more and more deranged until he is killed by security clones. No one believes his ranting. Although the sequel series shows that at least a few believed him.

* In ''VideoGame/WeHappyFew'', the entire populace of Wellington Wells is addicted to "Joy," which causes people to forget their troubles (especially the "Very Bad Thing") but also causes hallucinations and erratic behavior. Those who are not on Joy are brutally attacked by users until they either give in and take the drug, or are killed.

* One of the parts of the Project MKULTRA involved givivg drugs such as LSD so as to attempt mind control.

* In the ''ComicBook/{{Tintin}}'' album "[[Recap/TintinCigarsOfThePharaoh Cigars of the Pharoah]]", the Egyptologist Dr. Sarcophagus is given drugs to make him insane, so as to cover up an opium-smuggling ring that was running through Egypt. The Rajaijah Juice or "poison of madness" then pops up again in "[[Recap/TintinTheBlueLotus The Blue Lotus]]", though at the end of the album, Dr. Fang (who was kidnapped by the drug ring because they feared his research on madness) develops a cure for its effects.

* ''The Cosby Mysteries''. One victim is poisoned with mercury placed on the lampshade of his desklamp; the heat of the lamp vapourised the mercury and he inhaled the fumes, making him as mad as the proverbial hatter.

* Inverted in a LordPeterWimsey short story, where the villain withholds a drug that the victim needs to stay mentally healthy.

[[folder:Film]]

* Wiki/SCPFoundation: Dr. Clef once held an orientation meeting with new researchers on the subject of {{Reality Warper}}s. He'd spiked the food and drink with hallucinogens so that when he started yelling at them that reality ''was'' being changed, they believed it, driving home just how helpless you are against such [=SCPs=].

* In the ''ComicBook/{{Tintin}}'' album "[[Recap/TintinCigarsOfThePharaoh Cigars of the Pharoah]]", the Egyptologist Dr. Sarcophagus is given drugs to make him insane, so as to cover up an opium-smuggling ring that was running through Egypt. The Rajaijah Juice or "poison of madness" then pops up again in "[[Recap/TintinTheBlueLotus The Blue Lotus]]", though at the end of the album, Dr. Fang develops a cure for its effects.

* In ''Literature/TheKingkillerChronicle'', one of Kvothe's rivals doses him with an alchemical concoction that leaves him TheSociopath for a few hours, intending him to embarrass himself at an important moment. Although Kvothe runs his mouth in front of a younger student and has to be restrained from nonchalantly murdering said rival when he learns what's been done, his friends manage to get him to privacy before he does any real damage.

Compare PsychoSerum where a character intentionally takes a drug to [[SuperSerum enhance himself]], but it induces insanity as a side-effect; also compare InfectiousInsanity which is another "manufactured" way to cause insanity. See also {{Gaslighting}}, another way in which one character can make another seem insane.

* In ''VideoGame/WeHappyFew'', the entire populace of a town is addicted a chemical called "Joy," which causes hallucinations that make everything look like one big party, when in truth a "pinata" is actually a rat and the "candy" are its guts. Those who are not on Joy are brutally attacked by the users until they either give in and take the drug, or are killed.

* In the ''ComicBook/{{Tintin}}'' album "[[Recap/TintinCigarsOfThePharaoh Cigars of the Pharoah]]", the Egyptologist Dr. Sarcophagus is given drugs to make him insane, so as to cover up an opium-smuggling ring that was running through Egypt. The "poison of madness" then pops up again in "The Blue Lotus", though at the end of the album, Dr. Fang develops a cure for its effects.

* ''WesternAnimation/TheSimpsons '': In one "Treehouse of Horror" story, Kodos and Kang spray Homer with rum so people will dismiss his alien-abduction story as drunken ravings.

* Website/SCPFoundation: Dr. Clef once held an orientation meeting with new researchers on the subject of {{Reality Warper}}s. He'd spiked the food and drink with hallucinogens so that when he started yelling at them that reality ''was'' being changed, they believed it, driving home just how helpless you are against such [=SCPs=].

* In ''VideoGame/AssassinsCreedBrotherHood'', Ezio is able to give drugs to make the target assault passer-bys, much like a spree killer.

* ''Literature/HerculePoirot'': The Cretan Bull (part of TheLaboursOfHercules): the "bull" in this case is a huge and energetic young man named Hugh who is suffering from hallucinations and sometimes wakes up with bloodied hands and the news that animals have been found butchered nearby. As his family has a history of congenital madness, he's afraid of going off the deep end and resolves to commit suicide when he thinks he's close to harming his fiancée. [[spoiler:He's perfectly sound in mind, the hallucinations being produced by drugs in his shaving cream. The actual madman is his father- or rather, his mother's husband, who does suffer from the family insanity and resolved to drive Hugh to suicide in revenge, having murdered his wife years ago. He shoots himself once found out.]]

* One episode of ''Series/LawAndOrderSpecialVictimsUnit'' has a villain of the week who has a girl she was abusing (who witnessed her murder another child in her care) committed and drugged (she managed to convince the staff that the girl was legitimately insane, but the trope was otherwise in effect). Another episode inverts it, by having a corrupt nursing home take a patient off his meds to prevent him from telling anyone about a patient who died due to negligence.

* In the ''ComicBook/{{Tintin}}'' album "Cigars of the Pharoah", the Egyptologist Dr. Sarcophagus is given drugs to make him insane, so as to cover up an opium-smuggling ring that was running through Egypt. The "poison of madness" then pops up again in "The Blue Lotus", though at the end of the album, Dr. Fang develops a cure for its effects.

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