History Main / ASinisterClue

* ''Series/The100:'' [[InvertedTrope Inverted]] in season 6, when Clarke is subjected to a GrandTheftMe by Josephine Lightbourne, a member of the ruling class of the new planet they've landed on, and very much the villain of the season. Clarke is left-handed, while Josephine isn't, and is the sign Clarke's mother picks up on that Clarke is [[NotHimself Not Herself]]. Fortunately for Josie, Abby is distracted by her quest for a cure for mortally-injured Kane, so accepts a quick hand-waved explanation and hasty change in subject.

* ''VideoGame/FearEffect 2'': Inverted. Near the end of the game, Hana has to choose between shooting her girlfriend Rain or Rain's EvilTwin. Rain is actually the left-handed one, which is the main tipoff on the correct one to shoot.

->'''Batman''': Left-handed...
->'''Jack the Ripper''': Oh, the nuns beat that wickedness out of me. Always use my right... except for Jack's work.

** ''Film/StarWarsEpisodeIIAttackOfTheClones'': Anakin loses his right arm, symbolizing a move towards the Dark Side.
** ''Film/StarWarsEpisodeVTheEmpireStrikesBack'': Luke loses his right hand right before TheReveal that [[LukeIAmYourFather Darth Vader is his father]]. In ''Film/ReturnOfTheJedi'' Luke breaks free from his FreakOut after he cuts off his father's right hand and realizes that both of them have mechanical right hands.
* ''Film/{{Metropolis}}'': Rotwang is a MadScientist whose right hand is mechanical.

* ''ComicBook/{{Superman}}'': Lex Luthor had a mechanical right hand for a while; he lost the original to Kryptonite poisoning. Naturally, he took Rotwang's role in the {{Elseworld}} ''Superman's Metropolis''.

** ''Series/StarTrekDeepSpaceNine'': The Pah Wraith worshippers wear their earrings on their left ear instead of their right.

* ''WesternAnimation/TheBatman'': In one episode, Mirror Master creates evil duplicates of Batman, Robin, and Flash. Batman quickly notes that the duplicates are left-handed.

** ''VideoGame/KirbysReturnToDreamland'': [[spoiler:[[TreacherousQuestGiver Magolor]] is, if you look carefully in the fights against him, clearly left-handed, although you don't see this much until you already know he's evil.]]

* ''Fanfic/DanganronpaMementoMori'': The left-handed [[spoiler:Luka Aikuchi]] turns out to be the [[OnceAnEpisode "unsympathetic Chapter 3 killer"]], and is also [[spoiler:a DepravedDentist who moonlights as a SerialKiller, preying on [[DisposableVagrants homeless people]]]].

[[folder:Real Life]]
* Serial killers Jack the Ripper was alleged to have been left-handed, Theodor "Ted" Robert Bundy was left-handed, the same can be applied to Albert DeSalvo, AKA the Boston Strangler. [[https://www.ranker.com/list/left-handed-criminals/ranker-crime In other aspects]], criminals such as Osama bin Laden, Japanese Prime Minister and war criminal Hideki Tojo, and Public enemy John Dillinger were also left-handed. Lest anyone misconstrue these examples, please remember that with approximately 10% of the human race being left-handed, it can reasonably be expected that approximately 10% of criminals will be left-handed.
[[/folder]]

* ''Webcomic/{{Drowtales}}'': Kalki seems to be left-handed judging by how she [[http://www.drowtales.com/mainarchive.php?sid=10143 holds a katana]] and is mostly shown using her left hand for nether summoning.

* ''VideoGame/KirbysReturnToDreamland'': [[spoiler: [[TheMole Magolor]] is, if you look carefully in the fights against him, clearly left-handed, although you don't see this much until you already know he's evil.]] Furthermore, in ''VideoGame/KirbyAndTheAmazingMirror'', [[DarkIsNotEvil Meta Knight]] has his dominant hand inverted while within the mirror from right to left, however, while within the mirror, [[EvilTwin Dark Meta Knight]] still uses his right hand, implying that, in the normal world, he would be left-handed. [[ObviouslyEvil Not that you need that to tell that he's a bad guy.]]

* ''VideoGame/FearEffect2'': Inverted. Near the end of the game, Hana has to choose between shooting her girlfriend Rain or Rain's EvilTwin. Rain is actually the left-handed one, which is the main tipoff on the correct one to shoot.

* ''Manga/OnePiece'': An interesting case with the Straw Hats, as none of them are evil, but a large number of them have something of importance on their left side. Luffy has his scar underneath his left eye. Nami's tattoo is on her left arm. Zoro's earrings are on his left ear, and although ambidextrous appears to prefer his left hand. Usopp always wears his wrist band on his left hand. Sanji's left eye is always covered. Chopper's antler plate is located on his left antler. Interestingly enough, the two Strawhats that finally break this pattern, [[spoiler: Robin and Franky,]] are both introduced to the story as villains/antagonists to the Strawhats. [[spoiler: Brook]] then completely subverts it, as his one asymmetrical trait is on the right side of his face. Sanji also subverts this after the TimeSkip, when his PeekABangs switch eyes to cover his right one instead.

* ''Series/OrphanBlack'': Helena is the one clone who's left-handed, and she starts out as a villain. [[spoiler: It turns out that this is because she and Sarah are mirror-image twins, not clones.]]

* ''Film/TheNightOfTheHunter'': Reverend Harry Powell. The fingers on his right hand are [[KnuckleTattoos tattooed with the word L O V E]], while the left hand is tattooed H A T E. His CatchPhrase? "Do you want to hear the story of left-hand and right-hand?"

Additionally, in older times, left-handedness was often a sign of evil or trickery because of the fact that people would shake hands with their right, grabbing each other by the wrists, in order to show that they were friendly and [[NothingUpMySleeve didn't have weapons]]. Of course, this is incredibly small-minded since if left-handed people were in the majority then it would be the other way around. Still, a lefty could shake with their right hand, grasping the other person's dominant hand, and attack with their weapon in their left hand while the other was defenceless - or even steal a rightie's weapon more easily. Also, during the Middle Ages, towers were built so defenders would have no problem swinging their swords down staircases while attackers would have more difficulties swinging up - and staircases are still built this way to this day. However, this only applied if both were right-handed; if the attacker were left-handed, the two would be evenly matched.

In many cultures, before the invention of toilet paper and forks, the right hand [[note]]aka "dexter"[[/note]] was used for eating, greeting, etc., while the left hand was used for wiping and other less savory things. In some places, being left dominant was a sign that there was something inherently 'wrong' with the child, to the point of demonic possession, and to this day [[AbusiveParents some parents]] will tie a left-handed child's hand behind their back until they learn to be ambidextrous. Ironically this will not change the hand that you instinctively lead with in your daily interactions.

* Figures prominently in ''Anime/ReadOrDie''. ''Really'' prominently - will ruin the main plot twist if you read the spoiler. [[spoiler: Nancy is left-handed and is TheMole. Then to add to that she has an EvilTwin and they are differentiated only by their dominant hand. Inverted because the right-handed Nancy is the EvilTwin. As an alternative interpretation, it is not inverted because left-handed Nancy betrayed Yomiko first, and then betrayed and killed her own lover (although he had betrayed her), while right-handed Nancy was at least loyal to her man, making the left-handed Nancy experience a HeelFaceRevolvingDoor.]]
* Wrath of ''Anime/FullmetalAlchemist2003'' may or may not be left-handed, but he got the right one from someone else. The same could be said of Scar, though their alignments turn in opposite directions.
* Gin from ''Manga/CaseClosed'' is left-handed. Also, there is a case Conan solves by realizing a man had been replaced by a duplicate because the fake was left-handed and the original was not.
%%* ''Manga/DeathNote'':
%%** Higuchi, though nobody mentions it.
%%** From the viewpoint of the Kira followers, this would apply to Matt.

* Inverted by Nanoha, the left-handed heroine of the ''Franchise/LyricalNanoha'' series, which is full of right-handed villains. Unless you take her {{fanon}} [[BloodKnight reputation]] into consideration.
* In ''Manga/{{Naruto}}''

* In the first season of ''Anime/YuGiOh'', a duelist needs one of two entry cards to participate in the Duelist Kingdom playoff tournament; each such card indicates a prize to be claimed by the tournament's victor. Glory of the King's Opposite Hand is a blank card which entitles the holder to one wish granted by Pegasus J. Crawford, to the extent of his power, but the holder will risk getting their soul stolen if they lose. In contrast, Glory of the King's Hand depicts a treasure room filled with coins, jewels, and the like, and entitles the holder to three million yen [[note]] or dollars, [[DubText if you're watching the dub]] [[/note]]. Mai Kujaku and "Bandit" Keith Howard are in the tournament for the money, and take King's Hand. Jounouchi does, too, albeit in hopes of paying for his sister's desperately-needed eye surgery. Yugi only wants his to save his grandfather, so he uses King's Opposite Hand.

* In ''Manga/TokyoGhoul'', [[spoiler:the novelist Sen Takatsuki/Eto Yoshimura]] is left-handed and is eventually revealed to be a major villain of the series as the real One-Eyed Owl and the leader of Aogiri Tree. Downplayed in the sequel, however, as while she is vicious and amoral, [[spoiler: all her actions are geared to destroy the true villain of the series.]]
* Inverted in ''Manga/TheSevenDeadlySins'' one of the main characters Meliodas appears to be left-handed and a protagonist. However, there is ample evidence that this wasn't always the case. That also not taking into account that Meliodas is [[spoiler: a Demon]].
* In the [[MemeticMutation infamous]] "potato chip" scene in ''Manga/DeathNote'', Light, who is being monitored by camera, is shown solving math problems with his right hand while his left hand writes names into a piece of the Death Note he hid in a potato chip bag. It has been [[{{Fanon}} theorized]] that he actually is left-handed but was taught to use his right as per cultural norms.

* Inverted in the spy film, ''Film/TheBrainStealers''. An imposter infiltrating the Li's household (posing as the brother, after a FreakyFridayFlip) starts using his ''right'' hand, even though the righteous brother is left-handed. This ticks off the sister that something's amiss.
* [[TheFaceless Keyser Soze]] in ''Film/TheUsualSuspects'' is left-handed. A clue to his identity occurs early in the movie when [[spoiler:Verbal Kint tries to light a cigarette by holding the lighter in his right hand and opening it with his [[ObfuscatingDisability cerebral palsy-afflicted left hand]], but can't do it]].
* All the Stormtroopers in ''Franchise/StarWars'' are left-handed, due to the magazines on the left side of the prop guns constantly bumping into the Stormtroopers armor. Maybe this would explain ImperialStormtrooperMarksmanshipAcademy.
* In ''Film/RogueOne'', Director Orson Krennic is left-handed as well as being the major villain. He also aims his blaster pistol with his left hand.
* In the film adaptation of ''Film/ToKillAMockingbird'', Bob Ewell is stated to be left-handed rather than ambidextrous as in the book. This makes the fact that he beat his daughter, Mayella, even more obvious.
* As told in ''Film/ThePassionOfTheChrist'', a nail is driven into [[UsefulNotes/{{Jesus}} Christ]]'s hand by the left hand of the director, [[CreatorCameo Mel Gibson]]. The point is that all people, even the ones who worship Jesus and proclaim his passion to the world, are responsible for his death because he died due to the sinister part of each and every person.
* Thanos' Infinity Gauntlet in ''Film/AvengersInfinityWar'', with which he kills half the universe, is worn on his left hand. In contrast, [[spoiler: the new Gauntlet Tony and Bruce make to undo the damage in ''Film/AvengersEndgame'' is right-handed.]]
* Arthur Fleck in ''Film/Joker2019'' is right-handed, but he switches to his left hand (and left foot) more often when his Joker persona starts to emerge.

* Inverted (thematically at least) in the ''Literature/LoneWolf'' gamebooks: magic traditions inspired by the Forces of Light are referred to as "left-handed", while the BlackMagic of the servants of [[GodOfEvil God of Darkness]] [[BigBad Naar]] are referred to as "right-handed".

* Arya from ''Literature/ASongOfIceAndFire''. When her dominant hand is revealed to her fencing master, he reacts favorably because fighting left-handed will reverse her stance and movements, which will help confuse her opponents. However, her left-handedness might also be A Sinister Clue about her future, [[spoiler: training in a cult of assassins.]]

* In the novel ''Literature/TheSterkarmHandshake'', the whole Sterkarm clan are lefties and are known for being backstabbers.
* Bob Ewell in ''Literature/ToKillAMockingbird'' may be ambidextrous (in his words, he "can use one hand good as the other") but prefers his left, which becomes important at the trial, since the accused ''can't'' use his left arm.
* Inverted in the ''Literature/{{Goosebumps}}'' book ''Let's Get Invisible''. The narrator's brother is left-handed, so [[spoiler: seeing "him" pitch a baseball right-handed in the end clues in the narrator that he's been replaced by his evil reflection]].
* ''Literature/KaneSeries'': Kane is naturally left-handed, which helps him in combat, although he has trained himself to [[HeroicAmbidexterity use his right hand equally profficiently]], which helps him even more. He is also the world's [[CainAndAbel first murderer]].

* Played for laughs in some comedy (?) show called ''Inside Scoop'': [[https://www.youtube.com/watch?v=1GEI7HKE_D4 Ban Left Marriage!]]
* In ''Series/{{V|1983}}'', whenever a human is [[{{Brainwashed}} converted to the villains' cause]], it causes a brain-dominance switch. Since there are no lefties in TV Land, this leads to left-handed human collaborators.
* ''Series/StarTrekTheNextGeneration''
** Data figures out he and Picard are trapped in a holodeck Enterprise when (the simulation of) Geordi catches a tool Data throws to him with his left hand, exposing a programming glitch Data was already aware of (from playing a Sherlock Holmes mystery program.)
** Data reveals that his [[EvilTwin brother Lore]] was equipped with a Type L [[TechnoBabble Phase Discriminating Amplifier]] while Data was equipped with a Type R. Also averted by Data himself, who uses his left hand dominantly like his (and Lore's) actor [[Creator/BrentSpiner Brent Spiner]].
** The logo of the Borg Collective looks like a grasping left hand.
* In ''Series/StarTrekDeepSpaceNine'', the Pah Wraith worshippers wear their earrings on their left ear instead of their right.
* An episode of ''Series/{{Supernatural}}'' has Sam [[SpotTheImposter realize that a shapeshifter]] was pretending to be Dean because he caught something with his left hand, as Dean's left arm was injured.
* In ''Series/{{Graceland}},'' Briggs is left-handed. This trope is only invoked later in the first season, with the big reveal.
* In a Series/PerryMason movie, the title character, who has realized that the killer in question is left-handed, forces the culprit to reveal himself by asking him for the time. The man looks at his watch, which is on his ''right'' wrist, as many left-handed people wear it.
* A similar scene in ''Series/TheGoldenGirls'' episode "The Case of the Libertine Belle", where the girls went to a murder mystery weekend.
* On ''Series/OrphanBlack'', Helena is the one clone who's left-handed, and she starts out as a villain. [[spoiler: It turns out that this is because she and Sarah are mirror-image twins, not clones.]]
* On ''Series/{{Jekyll}}'', one of the differences between Hyde and Dr Jackman (Our "Jekyll") is that Hyde is left-handed while Dr Jackman is not.

* An episode of ''Series/UltramanAce'' seemingly features the return of Go Hideki, the human host of the previous series, [[Series/ReturnOfUltraman Ultraman Jack]]. Turns out that Hideki is actually an alien imposter, whose cover is blown when he starts using chopsticks with his left hand (the ''real'' Hideki is right-handed).

* In the Bible, the tribe of Benjamin were distinguished by having a predominance of left-handed people. Naturally this cursed streak led them to war with the rest of Israel, where their left-handed swordsmen and slingers were seen as an unnatural thing, able to preferentially target the unshielded side of an opponent and leave right-handed swordsmen at a fighting disadvantage when the enemy weapon came at them from the "wrong" side.
** Ehud, one of the judges, actually managed to assassinate a king by hiding a miniature weapon on his right hip. Thus the weapon wasn't found, and he could still use it, being left-handed.

* The titular Nemesis from ''VideoGame/ResidentEvil3Nemesis'' is a lefty. This is useful to know in gameplay because you dodge his punches and grabs by juking to his right side.

* The antagonist of ''VideoGame/{{Glover}}'', Cross-Stitch, is a left-hand glove, while the titular protagonist is a right-hand glove.
* In ''VideoGame/GodHand'', the titular artifact exists in a pair: left God Hand and right God Hand. The hero, Gene, got the right one to replace his severed arm. As for the left one, it's used by the [[TheDragon Dragon]] Azel (who is the most evil in the group of villains).
* In ''VideoGame/SuperSmashBros'', the Master Hand is a giant, floating, apparently benign right hand who created the world that the characters find themselves in, and lives to be the ultimate challenge for heroes. The idea is that he is the hand of the child making the trophies fight, just like a kid in his room playing with action figures. His EvilTwin is the Crazy Hand, the left hand of the pair, who laughs maniacally upon his entrance and whose attacks and general movements are both bizarre and incredibly erratic. Whereas Master Hand is said to be a benign force and to represent the creative nature of a child, Crazy Hand is a destroyer, and supposedly represents that same child's more sadistic qualities. In the end, Master Hand doesn't look particularly saintly himself with his equally EvilLaugh, and [[BigBadDuumvirate both hands]] still serve as the final bosses of the modes where they appear, so the implications of good versus evil between them are [[DownplayedTrope downplayed]].
* An odd example occurs in the online game ''VideoGame/ImprobableIsland'', where one of the monsters you can encounter is called "Sinister Dexter", an AffectionateParody of, well, ''Series/{{Dexter}}''. His moves are all based on being left-handed. [[RealityIsOutToLunch It's that kind of game]].
* The official art for ''VideoGame/CastlevaniaSymphonyOfTheNight'' depicts [[spoiler:cursed-by-Dracula]] Richter Belmont as a lefty; he is right-handed in the prior depictions of him. Hint hint much.
* While playing ''VideoGame/TheEvilWithin2,'' if you pay attention while watching or fighting MadScientist SerialKiller Stefano Valentini, you'll see that he holds and throws knives with his left hand.

** In ''VideoGame/PokemonColosseum'', the two models of the portable Snag Machine are depicted as being worn on the left arm. Neither of their wielders is particularly nasty ([[AntiHero though one moreso than the other]]), but the folks behind inventing the device are the epitome of evil in the Pokeverse.
** As a comparison, in ''[[VideoGame/PokemonXDGaleOfDarkness XD]]'', Michael always makes a regular catch (at the Poke Spots, given that's where wild Pokemon appear from time to time) or calls out a Pokemon with his right hand. He only uses his left when he needs to make a Snag.
** In ''VideoGame/PokemonSwordAndShield'', Bede always tosses his Poké Balls with his left hand and has a narcissistic attitude while being skilled enough as a Pokémon trainer to get away with most of what he claims. Subverted with Allister, who is a lefty CreepyChild but is a very nice individual and popular in his hometown.
* Inverted in ''VideoGame/TalesOfTheAbyss'', where TheHero is left-handed, [[spoiler:while his EvilTwin is right-handed, or at least favours his right hand in combat, allowing the pair to milk FearfulSymmetry for all its worth.]]
* Interestingly, the Wii version of ''VideoGame/TheLegendOfZeldaTwilightPrincess'' has [[BigBad Ganondorf]], traditionally right-handed, turned left-handed. This is because of the control scheme of the Wii, and since the deadline of the game was getting close, the developers couldn't simply make Link right-handed and leave the rest of the version intact, so they decided to simply mirror it, thus turning most characters left-handed, including Ganondorf.

* In ''VideoGame/KirbysReturnToDreamland'', [[spoiler: [[TheMole Magolor]] is, if you look carefully in the fights against him, clearly left-handed, though you don't see this much until you already know he's evil.]] Furthermore, in ''VideoGame/KirbyAndTheAmazingMirror'', [[DarkIsNotEvil Meta Knight]] has his dominant hand inverted while within the mirror from right to left, however, while within the mirror, [[EvilTwin Dark Meta Knight]] still uses his right hand, implying that, in the normal world, he would be left-handed. [[ObviouslyEvil Not that you need that to tell that he's a bad guy.]]
* Downplayed in ''Franchise/TheKingOfFighters''. Yes, Nameless uses his left hand for both wearing his PowerLimiter and to unleash his pyrokinetic abilities. Yes, he is a [[NebulousEvilOrganisation NESTS]] lapdog who performs assassinations for them without question. But compared to his peers (especially [[EvilCounterpart K9999]]) and superiors, he's one of [[TokenGoodTeammate the noblest members]] of the lot.
* ''VideoGame/DarkSoulsII''
** The Fume Knight, AKA Raime, held his {{BFS}} in his left hand. He was also known as the left hand of King Vendrick prior to his betrayal, while the more noble Velstadt was the right hand.
** The Burnt Ivory King is a tragic example. He was genuinely a nice person prior to his fallen hero due to the old Chaos.
* [[spoiler:Goro Akechi]] from ''VideoGame/Persona5'' is left-handed. Naturally, he's a villain [[spoiler:and the traitor among the main characters]]. Possibly an invoked trope, as the game heavily homages "Classy" works such as Literature/ArseneLupin, Literature/SherlockHolmes, Carmen, Literature/TheThreeMusketeers, (etc) where this trope cropped up.
* Inverted in ''[[VideoGame/FearEffect Fear Effect 2]]''. Near the end of the game, Hana has to choose between shooting her girlfriend Rain or Rain's EvilTwin. Rain is actually the left-handed one, which is the main tipoff on the correct one to shoot.
* Every human enemy in ''VideoGame/EightBitKiller'', except for [[BatterUp thornies]], carries a weapon in their left hand. A printable set of trading cards even describes Kingdar as [[TheDragon the "left hand" of Master Brain]].
* In ''Franchise/TheElderScrolls'' backstory, The ancient Yokudans (ancestors of the Redguards) fought a devastating war with the [[MeaningfulName Sinistral]] Mer, also known as the Left-Handed Elves, whose entire race was said to be left-handed. The war left the Sinistral Mer extinct.
* In ''VideoGame/FridayNightFunkin'', Daddy Dearest, Senpai, and [[{{WebAnimation/Tankmen}} Sergeant John Captain, AKA Tankman]] each hold the microphone in their left hand. In Senpai's case, it serves as {{Foreshadowing}} of his BitchInSheepsClothing personality [[spoiler:and Spirit hiding in his coding]].
* ''Franchise/LeagueOfLegends'' has [[FallenAngel Morgana the Fallen]], a LadyOfBlackMagic who -- [[DarkIsNotEvil while not strictly "evil"]] -- has a wicked appearance and casts shadowfire magic most predominantly from her left hand. This puts her [[PolarOppositeTwins in deliberate contrast to her angelic twin sister]], [[ThePaladin Kayle the Righteous]], who wields a holy sword in her right hand. It's especially notable considering this is only true following [[ArtEvolution their 2019 redesigns]] -- prior to the update, Kayle was lefthanded while Morgana didn't display a dominant hand, suggesting their current animations were done as [[RuleOfSymbolism very deliberate symbolism]].
* Leo from ''VideoGame/AWayOut'' is a convicted felon who, while ambidextrous, typically shoots and fights left-handed. [[spoiler:Fittingly enough, between him and the right-handed Vincent, he's the only one who's actually a criminal.]]
* In the ''VideoGame/GrandTheftAutoV'' mission "By The Book", Michael, on the FIB's behalf, has to locate and assassinate an alleged terrorist at a house party, with a handful of descriptors extracted from the target's associate by Trevor to go off of. One of these descriptors is that he's left-handed. Subverted, if the post-mission news reports are to be believed, as it's revealed that the assassination target was in fact a green energy mogul and philanthropist.

* Justified in ''VisualNovel/HatofulBoyfriend''. The ObviouslyEvil Dr. Shuu uses his left [[FeatherFingers wing]] for everything... because his right wing was injured in the past.
* Reinhard, the main BigBad of ''VisualNovel/DiesIrae'' is left-handed. There is also the {{Foil}} of the main character, Shirou Yusa, who is also left-handed. [[spoiler:This is not a coincidence as both are what is known as an Apoptosis, an embodiment of someone's hidden self-destructive desires]].
* This actually tends to get played with in ''VisualNovel/AceAttorney''. 3 victims in the series (Dustin Prince, Byrne Faraday, and Dumas Gloomsbury) are left-handed, and the fact the killers or prosecution tend to make the mistake of treating them as right-handed comes up as a contradiction that advance your case. There are two killers who are left-handed, [[spoiler: Yanni Yogi and Lance Amano, and the latter actually tries to use that to his advantage by using his non-dominant hand when he attacks Edgeworth with a prop sword to knock him out. However, Edgeworth manages to prove his handedness wouldn't matter thanks to the ease of using a prop sword.]]

* ''{{Webcomic/Drowtales}}'': Kalki seems to be left-handed judging by how she [[http://www.drowtales.com/mainarchive.php?sid=10143 holds a katana]] and is mostly shown using her left hand for nether summoning.
* ''{{Webcomic/Homestuck}}'': Marquise Spineret Mindfang is left-handed, writing in her journal after losing her left arm how she will "have to get used to writing with this hand instead."

* ''WebVideo/TheLegendOfZeldaTheSageOfDarkness'' features [[TheHeavy The Skull Kid]], who wields a whip with his left hand. This is a hint to his true identity of [[spoiler: the seemingly well-meaning Davik, who had his right hand cut off years past.]]

* In one "Treehouse of Horror" episode of ''WesternAnimation/TheSimpsons'', left-handed Bart turns out to be the evil twin of Hugo Simpson. Bart's left-handedness is never brought up in the episode though.
* Francine from ''WesternAnimation/AmericanDad'' was raised to think lefties were evil.
* In one episode of ''WesternAnimation/TheBatman'', Mirror Master creates evil duplicates of Batman, Robin, and Flash. Batman quickly notes that the duplicates are left-handed.

* The left hand of the titular character of ''Manga/HellTeacherNube'' is actually a sealed Oni, Baki, which replaces the left hand he lost fighting said Oni. Most of the time, it looks like his regular hand wearing a black leather glove; when his students are threatened by spectral horrors, he will reveal it as a monstrously large, dark red hand with visible tendons and black claws. However, he constantly seeks a way to seal it permanently, as only the influence of his childhood teacher prevents the Oni from taking over his entire body.
* The lead characters of ''Manga/{{Parasyte}}'' are a young man named Shinichi and the alien parasite that has possessed/replaced his right hand. Their relationship is one of the main foci of the series, especially re: Shinichi losing part of his humanity. As early as the first volume, the LoveInterest intuits there's something weird about his right hand and switches around him to hold his left instead.
** The original English translation was flipped and 'Migi' was named 'Lefty' instead.
* Edward Elric of ''Manga/FullmetalAlchemist'' lost his right arm and his brother lost his entire body performing forbidden alchemy, which put him on a self-imposed RedemptionQuest to restore his brother's real body. At the end of the story, [[spoiler: he has his right arm and his brother back, but Edward had to give up his ability to perform alchemy.]]

* [[Franchise/{{Superman}} Lex Luthor]] also had a mechanical right hand for a while; he lost the original to Kryptonite poisoning. Naturally, he took Rotwang's role in the {{Elseworld}} ''Superman's Metropolis''.

* Reverend Harry Powell from ''Film/TheNightOfTheHunter'' 1955. The fingers on his right hand are [[KnuckleTattoos tattooed with the word L O V E]], while the left hand is tattooed H A T E. His CatchPhrase? "Do you want to hear the story of left-hand and right-hand?"
* In ''Franchise/StarWars Episode II: Film/AttackOfTheClones'' Anakin loses his right arm -- symbolism of a move towards the Dark Side. Luke then loses his right hand in the same way [[Film/TheEmpireStrikesBack 3 films later]]--right before TheReveal that LukeIAmYourFather, and in ''Film/ReturnOfTheJedi'' Luke breaks free from his FreakOut after he cuts off his father's right hand and realizes that both of them have mechanical right hands.
* Rotwang ''Film/{{Metropolis}}'' 1926, here we have the subtrope with the MadScientist whose right hand is mechanical- also seen in Webcomic/GirlGenius with Professor Mongfish.

* In ''Literature/TheSilenceOfTheLambs'' books, Hannibal Lecter had six fingers on his left hand.
* Inverted in ''Literature/ASongOfIceAndFire''. When [[spoiler: Jaime Lannister]] loses his right hand, his moral compass actually starts working better. This is mostly because, without his sword hand, he's forced to think things through, when before he could just hack his way through any obstacle.

* In ''VideoGame/TheWorldEndsWithYou'' Sho Minamimoto has a black left hand.
* The main villain of ''VideoGame/FinalFantasyIV'', Golbez, is left-handed. However, you only learn this when [[spoiler:he's freed from brainwashing (done by the ''real'' villain) and becomes a protagonist in the sequel]]. He wields weapons in his left and shields in his right. Similarly, [[spoiler:Kain]] is left-handed, and ends up brainwashed to fight for the villain.
* Notably inverted with Link of ''Franchise/TheLegendOfZelda'', though this is absent in the Wii titles due to making motion-control-enabled games for a mostly-right-handed audience. It should be noted Creator/ShigeruMiyamoto himself is ambidextrous, preferring his left hand.

* WebVideo/TheLegendOfZeldaTheSageOfDarkness features [[TheHeavy The Skull Kid]], who wields a whip with his left hand. This is a hint to his true identity of [[spoiler: the seemingly well-meaning Davik, who had his right hand cut off years past.]]

* ''Franchise/GreenLantern'': Eventual villain Sinestro wears his power ring on his left hand. This furthered the association of him being an EvilCounterpart to the green lanterns he fought.

* In the infamous "potato chip" scene in ''Manga/DeathNote'', Light, who is being monitored by camera, is shown solving math problems with his right hand while his left hand writes names into a piece of the Death Note he hid in a potato chip bag. It has been [[{{Fanon}} theorized]] that he actually is left-handed but was taught to use his right as per cultural norms.

*** BigBad Golbez is left-handed but, aside from him, both Kain and Palom we subversions; the former has a case of HeelFaceRevolvingDoor but ultimately ends up as a Face, while the latter was never so much "evil" as they were [[BrattyHalfPint "a brat with a bad attitude."]] Both left-handed, both ultimately heroic.

Because we don't want to call left-handed people evil, '''Administrivia/NoRealLifeExamplesPlease'''

Because we don't want to call left-handed people evil,'''Administrivia/NoRealLifeExamplesPlease'''

'''Administrivia/NoRealLifeExamplesPlease'''

NoRealLifeExamples,Please!