History HalfHumanHybrid / AnimeAndManga

* In the manga of ''Manga/MahouSenseiNegima'' it is revealed that Setsuna is half-{{tengu}}. This is hinted at in the last episode of the anime, but never said outright.

* In ''Manga/NagasareteAirantou'', we have Michiru. Her father is human while her mother is a [[{{Youkai}} Yuki-onna]].
* ''Manga/{{Naruto}}'' introduces this concept later on in the series. [[spoiler:Kaguya Ōtsutsuki is the predecessor of some of the ninja world's most powerful clans, with the Uzumaki, Senju, Hyuuga, and Uchiha confirmed to be among her descendants. This means that every person descended from her through her sons Hamura and Hagoromo possesses alien ancestry, including Naruto and Kushina Uzumaki, Sasuke and Itachi Uchiha, Hinata and Neji Hyuuga, and Hashirama and Tobirama Senju.]]

* The heroine Chisaya from ''OnikirisamaNoHakoirimusume'' is half-human and half-yokai, with a giant {{Kitsune}} as a mother.

** It wouldn't be an Evangelion ripoff without an Ayanami Rei expy.

** The sequel ''Anime/YashahimePrincessHalfDemon'' introduces Towa and Setsuna, [[spoiler:who are the half-demon twin daughters of Sesshomaru, Inuyasha's half brother.]] Their cousin Moroha is an UnevenHybrid, [[spoiler:being the daugher of Inuyasha and Kagome (who is fully human).]]

* Anime/NeonGenesisEvangelion has [[spoiler:Ayanami Rei]], who is part human and part [[spoiler:Angel]].
* [[spoiler:Ryuko Matoi]] in ''Anime/KillLaKill'' is revealed as having been half-fused with Life Fibers since infancy, which explains why [[spoiler:she can hear Senketsu speak and why injuries she sustains [[HealingFactor rarely last for more than a few minutes.]]]]
* ''Manga/SilverDiamond'' has Chigusa: half-man, half-plant. Which apparently makes you damn near immortal. [[spoiler:Apparently, it's a family trait of the Senroh clan, earning them the title of Immortal Monsters.]]

* ''Manga/OtomeYoukaiZakuro'' is set during the Westernization of an alternate Japan, where humans and spirits (youkai) coexist. To solve the problems that arise between the two, human lieutenants are partnered with half-spirit girls to form the Ministry of Spirit Affairs.

* In ''Anime/TekkamanBlade'', the Tekkaman are basically half-Human, half-Tekkaman. [[spoiler:They are not half-Radam because Radam are actually a brainwashing parasite.]]

* The Crow special agents in ''Manga/DGrayMan'' are half-human and half-akuma - they're akuma enough to set off [[CursedWithAwesome Allen's eye]], but human enough to not actually be seen with it. Exactly how they got that way has yet to be revealed, but Black Religious Order experimentation by their Chief is a big part of it.

** it wouldn't be an Evangelion ripoff without an Ayanami Rei expy.

* In ''Manga/FullmetalAlchemist'', [[spoiler:one minor villain, Tucker, creates a "chimera" - that is, a creature that is a fusion of two creatures of different species - by using alchemy to fuse his five-year-old daughter, [[TheCutie Nina]], with her dog, Alexander. The result is pathetic creature that lives in constant pain and can barely talk, though still loves its "father". Eventually, Scar comes across Tucker and the [[KillTheCutie chimera]] and kills them both.]]
** It's heavily implied that [[spoiler:Tucker had previously used his wife as half of another chimera, resulting in creature that said "I want to die" before dying shortly afterwards]].

** Jinenji is also half-youkai, half-human; the species of his youkai parent is apparently some kind of horse demon. Unlike Inuyasha, his appearance is much uglier and more beastial. However, he's inherited healing powers from his youkai side and is incredibly gentle, contrasting the prettier, aggressive, violent Inuyasha. Jinenji has also inherited phenomenal physical strength, but he almost never uses it due to being a pacifist.

* In the manga of ''Manga/MahouSenseiNegima'' it is revealed that Setsuna is half-{{tengu}}. This is hinted at in the last episode of the anime, but never said outright.
** The manga also features Kotaro Inugami, a boy who is half-Dog Demon/Youkai.
** [[spoiler:Mana]] is later revealed to be [[OurDemonsAreDifferent half-demon]].
* In ''[[VisualNovel/{{Demonbane}} Kishin Houkou Demonbane]]'' the BigBad is revealed to be the offspring of [[spoiler:Nero and Yog-Sothoth]]. It's never explained how this happened, which, for the sake of our sanity, is probably for the better... and [[spoiler:he ''burst'' out of Nero's body, fully grown. And that his birth happened several episodes after he was killed.]]
* In ''Anime/PleaseTeacher'', the female protagonist, along with her sister, are half-alien, half-human.
* Both Averted & Justified in Creator/OsamuTezuka's ''Manga/{{Phoenix}}'' series, where there is only one species capable of breeding with others, the Moopies, who are able to do this due to VoluntaryShapeshifting (which is a completely different scientific impossibility, but what the hey).
* [[spoiler:Rue]] from ''Anime/PrincessTutu'' has been raised on [[spoiler:the Raven's blood]], and it's implied that it's made her a sort of hybrid.
* An arc exclusive to the ''Manga/RanmaOneHalf'' manga the Musk Dynasty, men who are half various animals. This was only possible because their ancestors used the cursed springs to turn animals into women, but they somehow [[SuperPowerfulGenetics inherited incredibly useful traits]] of their mothers' true forms (such as an acute sense of smell, superhuman strength, and, in the half-dragon's case, flight.)
* In the manga/anime ''Manga/{{Saiyuki}}'', humans and demons may interbreed, but the offspring, known as "children of taboo", are discovered to be infertile.
** [[spoiler:Homura]] from the ''Gensoumaden'' anime is a human/deity hybrid. Like with the human/demon pairings, such relationships are forbidden, so children of that kind are considered "unclean beings" by Heaven and end up in the role of tykebombs.

* ''VisualNovel/{{Shuffle}}'' involves two extra humanoid races, the Gods and Demons... and hybrids will happen.
** [[spoiler:Asa Shigure]] looks fully human and lets everyone think so, but we eventually find out she's half Demon. Her mother was [[spoiler:the first test subject of Project Yggdrasil]].
** Mayumi is also a half-Demon. She doesn't hide her parentage, but could if she wanted to.
** And then there's Sia... kind of. Her father is a God and her mother a Demon, but apparently race works like gender in the divine realms -- the child turns out either one or the other, not a mix of the two. Thus, while she ''is'' a hybrid, Sia is still all God biologically.
* Everyone except the hero in ''VideoGame/{{Utawarerumono}}'' has a varying combination of wings, long furry ears, and tails. It is revealed in the end that [[spoiler:they're all descendants of genetically engineered research experiments who escaped shortly before [[AllThereInTheManual the end of mankind]]. Despite having only minimal animal features, they were on the level of lab rats and dissected for research.]]
* In ''Anime/VoltesV'', [[spoiler:the Go/[[CulturalTranslation Armstrong]] brothers]] are revealed to be half-Boazanian. This is because [[spoiler:their DisappearedDad, Professor Kentarou Go, is actually a [[FallenPrincess fallen prince]] of the Boazanian Empire, a victim of his people's FantasticCasteSystem.]] For added tragedy, [[spoiler:his ''other'' son is none other than Prince Heinel, aka TheDragon under the orders of Lagour/Kentarou's evil younger brother Emperor Zambajil.]]
* ''LightNovel/{{Slayers}}'' has Zelgadis, an artificial example of this trope. He was born pure human, but was merged with a Blow Demon (a kind of Astral Goblin) and a stone {{Golem}} through the magic of Rezo, the Red Priest. This gives him pointed ears, blue skin, purple/lavender hair, patches of pebble-like "growths" all over his body, and either skin or flesh of solid rock.
* ''Manga/DragonHalf'' has the heroine Mink, whose mother was a dragon and whose father was a (human) dragon hunter. And Princess Vina, whose father was a king, and whose mother was a slime (similar to those in ''VideoGame/DragonQuest'').
* Being a ''TabletopGame/DungeonsAndDragons'' {{expy}}, ''Roleplay/RecordOfLodossWar'' has a few of these, the most traditional of these being Leaf, the Shaman from the Chronicles of the Heroic Knight TV series. Being Half Human and Half Elven, she is correctly referred to as a Half-Elf.
* The heroine Chisaya from ''OnikirisamaNoHakoirimusume'' is half-human and half-yokai, with a giant {{Kitsune}} as a mother.
* This seems to happen a lot in ''Manga/OnePiece''. There are several variations between common species, including but not limited to; Humans, [[FishPeople Mermen, Fishmen,]] and Giants. And since One Piece usually adheres to the RuleOfCool most hybrids get strengths of both parents' species with few, if any, of the relative weaknesses.
* ''Anime/TengenToppaGurrenLagann'' has the Beastmen, a race of Hybrids that serve as the antagonists for the 1st Season.

* Rin from ''Manga/BlueExorcist'' is half-demon, specifically the resident AntiAntiChrist and TheHero. It is a little played with though: although Rin gets the usual treatment hybrids get in fiction, it is later revealed that it isn't exactly because he is a half-blood -- apparently, a lot of exorcists have mixed heritage -- but because he is a son of [[BigBad Satan]] himself. [[spoiler:For example, Izumo is descended from a Byakko, though at this point it's such a distant relationship it doesn't truly count except for some special leanings in the family line, including apparently some very StrongFamilyResemblance.]]
* Nao from ''Manga/BloodyCross'' is half human, half angel.

* This is briefly discussed in ''Anime/EurekaSeven'' with regards to the biological compatibility of Renton (human) and Eureka (Coralian). After a few medical tests, there was said to be no problem.
* In ''Anime/EurekaSevenAO'', the protagonist Ao is a half human and half Coralian hybrid. Later on it's revealed [[spoiler:[[ThereIsAnother he may not be the only one...]] though the truth is still pretty ambiguous.]]
** [[spoiler:He ''is'' the only one. Midway through the series, Ao and the audience found out that his parents, Eureka and Renton (come on, it was obvious) had a girl before they had him. Sadly, the final episode reveals that she died at birth due to high trapar exposure in the original timeline (well the timeline of the movie) reacting badly with hybrids. Ao only survived because he was born on a different Earth which was simply TwentyMinutesIntoTheFuture.]]
* In ''Anime/WickedCity'', [[spoiler:the human Renzaburou and the demon Makie not only become a BattleCouple, but conceive a child. This is actually a part of a BatmanGambit by their boss Giuseppe: theirs is the ''first'' half-human, half-demon kid, and his/her existence will be the living proof that humans and demons can live in peace.]]
* In ''Anime/DevilMayCryTheAnimatedSeries'', this is blatantly stated by Bradley to Dante. This is highly uncommon because demons tend to enjoy tormenting and killing humans. However, Dante's father was a demon who [[RebelLeader rebelled against the demon emperor]] and sided with humans. Afterwards, he ruled the human world and had two twin sons, Dante and Vergil, before disappearing.

* The LightNovel ''LightNovel/{{Vamp}}!'' features a [[{{Dhampyr}} half-vampire]], Watt, who is impervious to sunlight but is said to never be able to reach the same level of power as regular vampires.
* In ''Anime/BlueCometSPTLayzner'', Eiji and Julia are the children of a Japanese astronaut and a Gradosian woman.
* In ''LightNovel/TheFamiliarOfZero'', Tiffania had a human father and an elf mother. Other than inheriting the PowerOfTheVoid and GagBoobs from her father's bloodline (both of these traits are unusual in an elf), she looks just like any other elf.

* Yuu Mishouzaki's [[Manga/TheLegendOfZelda Zelda manga]] was created back when we knew very little about Hyrule or Zelda lore. As such the concept of Hyrulians wasn't really a thing so the manga had them as "elves". The elves are [[FantasticRacism discriminated against]] but the Queen had a romance with an elf. Link is the child born from said romance.
* Imagine OrdinaryHighSchoolStudent Aoi Mitsukuni's surprise when he learns he's not only a half-human hybrid, his mother is none other than the infamous Anime/SpacePirateMito! Which would be a problem just because of her species' [[BizarreAlienBiology really odd form of puberty]] even if it weren't for the whole HiddenBackupPrince of the entire Galaxy thing.
* ''Franchise/KagerouProject'': Shion Kozakura, daughter of Azami ([[GorgeousGorgon Medusa]]) and Tsukihiko (human soldier) and by extension, her daughter Marry (whose father is human, but not shown). This actually comes into play in the story when [[spoiler:Shion is forced to [[TakenForGranite use her power]] to defend Marry; the [[HeroicRROD strain of using her powers despite being half-human kills her]]]].
* In ''Manga/TokyoGhoul'', One-Eyed Ghouls are said to be half-human and half-Ghoul. Protagonist Kaneki Ken becomes one after an organ transplant, and learns that others may exist as well. The legendary One-Eyed Owl is rumored to be a naturally-occurring hybrid, though this is the stuff of urban legend in the Ghoul community. However, these hybrids are noted to be more powerful than ordinary Ghouls and are invisible to the RC scanners the [[HunterOfMonsters CCG]] uses to detect Ghouls. Their name comes from the fact their GameFace only has one [[BlackEyesOfEvil Kakugan]], as opposed to both eyes changing. The sequel reveals more about these legendary hybrids: [[spoiler:In reality, the vast majority of hybrids are virtually identical to their human parent and lack most of their ghoul parent's abilities. Their enhanced physical abilities and [[BlessedWithSuck significantly]] shortened lifespan make them ideal as disposable {{Tyke Bomb}}s for the CCG. Arima, the oldest of the hybrids, reveals that he is dying from old age.....at the age of '''32''']].

* ''Manga/{{Naruto}}'' introduces this concept later on in the series. [[spoiler:Kaguya Ōtsutsuki is the predecessor of some of the ninja world's most powerful clans, with the Uzumaki, Senju, Hyuuga, and Uchiha confirmed to be among her descendants. This means that every person descended from her through her sons Hamura and Hagoromo possesses alien ancestry, including Naruto and Kushina Uzumaki, Sasuke and Itachi Uchiha, Hinata and Neji Hyuuga, and Hashirama and Tobirama Senju.]]
* In ''Manga/GreenWorldz'', there are humans with different forms and abilities that are hunting humans down for reasons of their own. They are literally just refered to as "Hybrid humans". Few info is known about them except they are [[FromASingleCell near impossible to kill through conventional means]] and [[RunOrDie avoiding them would be a priority for survival]]. Even badass Iwatobi who [[spoiler:time traveled from 30 years of the future]] could not come up with easy tips to deal with them.
* Eina in ''LightNovel/IsItWrongToTryToPickUpGirlsInADungeon'' is a human-elf hybrid. However, her example is far more mundane than most examples here--while other elf characters in this universe are badasses in different ways, she's an OfficeLady without special powers.
** The brave [[ActionGirl action girl]] Ais Wallenstein is also a hybrid. She is a half-fairy, as it later turns out in the manga.
* Akihito in ''LightNovel/BeyondTheBoundary'' is half-demon, half-human, which makes him have NighInvulnerability as his wounds always heal despite the damage he gets.
* ''Anime/IlSolePenetraLeIllusioni'' has a spoilerific example. [[spoiler:Akari's father was possessed by a Daemonia at the time of her conception, making her half-human, half-Daemonia, and this is why she can hear Daemonia's voices. Cerebrum also intends to use her to create a new breed of Daemonia.]]
* In ''Anime/{{Endride}}'', Louise is half-[[BeastMan Zoozian]], and although she has been able to pass as fully human because of her appearance, she grew up facing the discrimination and censure that was brought upon her [[MalignedMixedMarriage parents]] due to Fantastic Racism.
* At the end of the manga of ''LightNovel/SpiceAndWolf'', the wolf goddess Horo from the human Lawrence is pregnant.
* In ''Manga/{{Berserk}}'' there is the young girl Isma, which is the daughter of a human and a mermaid.
* It's unknown what the exact percentage is, but Couvert from ''Anime/DogDays'' is part human (though [[LittleBitBeastly residents]] of Flonyard are called humans anyways) since she's a descendant of the hero king Adelaide. A quick shot in the second season shows that she has both squirrel and human ears.
* [[AllThereInTheManual According to the official website]], Midori from ''Anime/SpacePatrolLuluco'' is half human/half alien.
* ''LightNovel/ShakuganNoShana'' has Justus. His father was a human, and his mother was a [[OurDemonsAreDifferent mighty demon]].
* ''LightNovel/SoICantPlayH'': At first, Ryouske's run-in [[{{Shinigami}} with Lisara]] seems like a chance encounter. But, in episode 8, his mother recounts having met Ryosuke's father under the exact same circumstances, with heavy implications that he was [[SpiritWorld from Grimwald]], the same as Lisara. Since his mother became pregnant with Ryosuke as a result of sleeping with his father, it'd mean he's half human and half shinigami.
* ''Manga/AttackOnTitan'' has the [[spoiler:Ackerman]] family, who are a result of "titan science". [[spoiler:All titans are technically humans originally, but the family's SuperStrength is directly a result of their titan connections.]]

* ''Manhua/RetiredHeroes'': Tifa is half demon, which occasionally gets her glares in the village. However, the fact that her demon mother is one of the town heroes (albeit a surly one) means it doesn't get too bad.
* ''LightNovel/GrimoireOfZero'' has the beast souls. They look like humanoid animals. And though some of them are transformed by magic, most of them are born that way. Their parents are both humans, yet they are expressly considered a mixture of humans and animals.

* NeonGenesisEvangelion has [[spoiler:Ayanami Rei]], who is part human and part [[spoiler:Angel]].

* Kaira from ''Anime/YokaiWatchShadowsideTheReturnOfTheOniKing'' is a human/yokai hybrid. He looks like a human, except for his [[YouGottaHaveBlueHair blue hair]] and TechnicolorEyes, and he is treated like a yokai. Kaira believes he hated by yokai due to HalfBreedDiscrimination, but Enma believes it's because of his dark side.

* In ''Anime/{{Endride}}'', Louise is half-[[PettingZooPeople Zoozian]], and although she has been able to pass as fully human because of her appearance, she grew up facing the discrimination and censure that was brought upon her [[MalignedMixedMarriage parents]] due to Fantastic Racism.

* In the ''Anime/TenchiMuyo'' OVA, you pretty much need a scorecard to figure out the entire linage of the Juraian Empire as just about everyone after Azusa is part human in some way. ''Anime/TenchiUniverse'' is a lot better at it as Tenchi's 3/4ths human, 1/4th Juraian with his mother, Achika, 1/2 human and 1/2 Juraian.

** ''Anime/MacrossDelta'' gives us another 2nd generation part-Zentran character in Mirage Fallyna Jenius, the granddaughter of Max and Millia (and Mylene's niece). Again, as with Ranka this goes to show how relatively normal human-alien hybrids have become at this point in the timeline.

* ''Franchise/{{Naruto}}'' introduces this concept later on in the series. [[spoiler:Kaguya Ōtsutsuki is the predecessor of some of the ninja world's most powerful clans, with the Uzumaki, Senju, Hyuuga, and Uchiha confirmed to be among her descendants. This means that every person descended from her through her sons Hamura and Hagoromo possesses alien ancestry, including Naruto and Kushina Uzumaki, Sasuke and Itachi Uchiha, Hinata and Neji Hyuuga, and Hashirama and Tobirama Senju.]]

* Zero Two from ''Anime/DarlingInTheFranxx'' is part-Klaxosaur, part-human, hence why she has horns and fangs. [[spoiler:Her original form is seen in Episode 13, as she had red skin, more prominent horns, claws, and serrated teeth as a child]].

* ''Franchise/{{Naruto}}'' introduces this concept later on in the series. [[spoiler:Kaguya Ōtsutsuki is the predecessor of some of the ninja world's most powerful clans, with the Uzumaki, Senju, Kaguya, Hyuuga, and Uchiha confirmed to be among her descendants. This means that every person descended from her through her sons Hamura and Hagoromo possesses alien ancestry, including Naruto and Kushina Uzumaki, Sasuke and Itachi Uchiha, Hinata and Neji Hyuuga, and Hashirama and Tobirama Senju.]]

* According to ''Manga/PokemonSpecial'', Mewtwo was partially augmented with human DNA.

* In ''Manga/TokyoGhoul'', One-Eyed Ghouls are said to be half-human and half-Ghoul. Protagonist Kaneki Ken becomes one after an organ transplant, and learns that others may exist as well. The legendary One-Eyed Owl is rumored to be a naturally-occurring hybrid, though this is the stuff of urban legend in the Ghoul community. However, these hybrids are noted to be more powerful than ordinary Ghouls and are invisible to the RC scanners the [[HunterOfMonsters CCG]] uses to detect Ghouls. Their name comes from the fact their GameFace only has one [[BlackEyesOfEvil Kakugan]], as opposed to both eyes changing. The sequel reveals more about these legendary hybrids: [[spoiler:In reality, the vast majority of hybrids are virtually identical to their human parent and lack most of their ghoul parent's abilities. Their enhanced physical abilities and [[BlessedWithSuck significantly]] shortened lifespan make them ideal as disposable TykeBombs for the CCG. Arima, the oldest of the hybrids, reveals that he is dying from old age.....at the age of '''32''']].

** Inuyasha is half-dog-{{youkai}} and has a mixture of dog and human traits. He's mostly human in appearance ([[LittleBitBeastly aside from his gray hair and dog ears]]) but has supernatural powers, dog fangs, SupernaturalGoldEyes, claws, and a hyperacute sense of hearing and smell. His abilities are inferior to his full-blooded [[UpToEleven daiyoukai]] brother's, but having a daiyoukai father means he's much stronger than powerful, but ordinary, youkai. One night a month he's forced to [[BroughtDownToNormal transform into a human]], and if his life is in grave danger a SuperPoweredEvilSide takes over where his youkai blood takes control of his mind and body.

** Inuyasha is half-dog-{{youkai}} and has a mixture of dog and human traits. He's human in appearance but has supernatural powers, dog fangs, SupernaturalGoldEyes, claws, and a hyperacute sense of hearing and smell. His abilities are inferior to his full-blooded [[UpToEleven daiyoukai]] brother's, but having daiyoukai father means he's much stronger than powerful, but ordinary, youkai. One night a month he's forced to [[BroughtDownToNormal transform into a human]], and if his life is in grave danger a SuperPoweredEvilSide takes over where his youkai blood takes control of his mind and body.
** Jinenji is also half-youkai, half-human, but the species of his youkai parent is unknown. Unlike Inuyasha, his appearance is much uglier and more beastial. However, he's inherited healing powers from his youkai side and is incredibly gentle, contrasting the prettier, aggressive, violent Inuyasha. Jinenji has also inherited phenomenal physical strength, but he almost never uses it due to being a pacifist.

* ''Manga/SilverDiamond'' has Chigusa: half-man, half-plant. Which apparently makes you damn near immortal. [[spoiler: Apparently, it's a family trait of the Senroh clan, earning them the title of Immortal Monsters.]]

* In ''Manga/FullmetalAlchemist'', [[spoiler: one minor villain, Tucker, creates a "chimera" - that is, a creature that is a fusion of two creatures of different species - by using alchemy to fuse his five-year-old daughter, [[TheCutie Nina]], with her dog, Alexander. The result is pathetic creature that lives in constant pain and can barely talk, though still loves its "father". Eventually, Scar comes across Tucker and the [[KillTheCutie chimera]] and kills them both.]]
** It's heavily implied that [[spoiler: Tucker had previously used his wife as half of another chimera, resulting in creature that said "I want to die" before dying shortly afterwards]].

* In ''Anime/VoltesV'', [[spoiler: the Go/[[CulturalTranslation Armstrong]] brothers]] are revealed to be half-Boazanian. This is because [[spoiler: their DisappearedDad, Professor Kentarou Go, is actually a [[FallenPrincess fallen prince]] of the Boazanian Empire, a victim of his people's FantasticCasteSystem.]] For added tragedy, [[spoiler: his ''other'' son is none other than Prince Heinel, aka TheDragon under the orders of Lagour/Kentarou's evil younger brother Emperor Zambajil.]]

* Rin from ''Manga/BlueExorcist'' is half-demon, specifically the resident AntiAntiChrist and TheHero. It is a little played with though: although Rin gets the usual treatment hybrids get in fiction, it is later revealed that it isn't exactly because he is a half-blood -- apparently, a lot of exorcists have mixed heritage -- but because he is a son of [[BigBad Satan]] himself. [[spoiler: For example, Izumo is descended from a Byakko, though at this point it's such a distant relationship it doesn't truly count except for some special leanings in the family line, including apparently some very StrongFamilyResemblance.]]

* In ''Anime/EurekaSevenAO'', the protagonist Ao is a half human and half Coralian hybrid. Later on it's revealed [[spoiler: [[ThereIsAnother he may not be the only one...]] though the truth is still pretty ambiguous.]]
** [[spoiler: He ''is'' the only one. Midway through the series, Ao and the audience found out that his parents, Eureka and Renton (come on, it was obvious) had a girl before they had him. Sadly, the final episode reveals that she died at birth due to high trapar exposure in the original timeline (well the timeline of the movie) reacting badly with hybrids. Ao only survived because he was born on a different Earth which was simply TwentyMinutesIntoTheFuture.]]

* In ''Manga/{{Sekirei}}'', it is revealed that [[spoiler: Minato and the other Ashikabi are essentially this because their ancestors were Sekirei that mated with humans in ancient times. Their alien heritage is expressed to a degree that they've been described as something other than human, but lack a Sekirei's core or powers.]]

* In ''Manga/TokyoGhoul'', One-Eyed Ghouls are said to be half-human and half-Ghoul. Protagonist Kaneki Ken becomes one after an organ transplant, and learns that others may exist as well. The legendary One-Eyed Owl is rumored to be a naturally-occurring hybrid, though this is the stuff of urban legend in the Ghoul community. However, these hybrids are noted to be more powerful than ordinary Ghouls and are invisible to the RC scanners the [[HunterOfMonsters CCG]] uses to detect Ghouls. Their name comes from the fact their GameFace only has one [[BlackEyesOfEvil Kakugan]], as opposed to both eyes changing. The sequel reveals more about these legendary hybrids: [[spoiler: In reality, the vast majority of hybrids are virtually identical to their human parent and lack most of their ghoul parent's abilities. Their enhanced physical abilities and [[BlessedWithSuck significantly]] shortened lifespan make them ideal as disposable TykeBombs for the CCG. Arima, the oldest of the hybrids, reveals that he is dying from old age.....at the age of '''32''']].

* ''Franchise/{{Naruto}}'' introduces this concept later on in the series. [[spoiler: Kaguya Ōtsutsuki is the predecessor of some of the ninja world's most powerful clans, with the Uzumaki, Senju, Kaguya, Hyuuga, and Uchiha confirmed to be among her descendants. This means that every person descended from her through her sons Hamura and Hagoromo possesses alien ancestry, including Naruto and Kushina Uzumaki, Sasuke and Itachi Uchiha, Hinata and Neji Hyuuga, and Hashirama and Tobirama Senju.]]
* In ''Manga/GreenWorldz'', there are humans with different forms and abilities that are hunting humans down for reasons of their own. They are literally just refered to as "Hybrid humans". Few info is known about them except they are [[FromASingleCell near impossible to kill through conventional means]] and [[RunOrDie avoiding them would be a priority for survival]]. Even badass Iwatobi who [[spoiler: time traveled from 30 years of the future]] could not come up with easy tips to deal with them.